Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women.

Arazi, H., Salek, L., Nikfal, E., Izadi, M., Tufano, J.J., Elliott, B. and Brughelli, M. 2020. Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women. Journal of translational medicine. 18 (239) 239. https://doi.org/10.1186/s12967-020-02411-y

TitleComparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women.
TypeJournal article
AuthorsArazi, H., Salek, L., Nikfal, E., Izadi, M., Tufano, J.J., Elliott, B. and Brughelli, M.
Abstract

BACKGROUND:Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resistance training in comparison with constant resistance training. The aim of the present study was therefore to examine the effects of chain-loaded variable and constant gravity-dependent resistance training on resting hormonal and neuromuscular adaptations. METHODS:Young women were randomly assigned to variable resistance training (VRT; n = 12; age, 23.75 ± 3.64 years; and BMI, 26.80 ± 4.21 kg m-2), constant resistance training (CRT; n = 12; age, 23.58 ± 3.84 years; BMI, 25.25 ± 3.84 kg m-2), or control (Con; n = 12; age, 23.50 ± 2.93 years; BMI, 27.12 ± 12 kg m-2) groups. CRT performed 8-week total-body free-weight training three times per week with moderate-to-high intensity (65-80% 1RM; periodized). VRT was the same as CRT but included variable resistance via chains (15% of total load). Resting serum samples were taken before and after the 8-week intervention for GH, IGF-1, cortisol, myostatin, and follistatin analyses. RESULTS:Both VRT and CRT groups displayed moderate-to-large significant increases in GH (197.1%; ES = 0.78 vs. 229.9%; ES = 1.55), IGF-1 (82.3%; ES = 1.87 vs. 66%; ES = 1.66), and follistatin (58.8%; ES = 0.80 vs. 49.15%; ES = 0.80) and decreases in cortisol (- 19.9%; ES = - 1.34 vs. - 17.1%; ES = - 1.05) and myostatin (- 26.9%; ES = - 0.78 vs. - 23.2%; ES = - 0.82). Also, VRT and CRT resulted in large significant increases in bench press (30.54%; ES = 1.45 vs. 25.08%; ES = 1.12) and squat (30.63%; ES = 1.28 vs. 24.81%; ES = 1.21) strength, with no differences between groups. CONCLUSIONS:Implementing chain-loaded VRT into a periodized resistance training program can be an effective alternative to constant loading during free-weight RT among untrained young women.

KeywordsChain-loaded resistance training
Traditional Resistance Training
Hormone
Muscle
Strength
Article number239
JournalJournal of translational medicine
Journal citation18 (239)
ISSN1479-5876
Year2020
PublisherBMC
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1186/s12967-020-02411-y
PubMed ID32539753
Web address (URL)https://europepmc.org/articles/PMC7296723
Publication dates
Published15 Jun 2020
FunderInstitutional

Related outputs

Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females
Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards, Adrian Soto-Mota, Kenneth Brookler and Bradley T. Elliott 2024. Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females. Biomedicines. 12 (7) 1553. https://doi.org/10.3390/biomedicines12071553

Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model
Cooper, Isabella D., Sanchez-Pizarro, Claudio, Norwitz, Nicholas G., Feldman, David, Kyriakidou, Yvoni, Edwards, Kurtis, Petagine, Lucy, Elliot, Bradley T. and Soto-Mota, Adrian 2023. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model. Frontiers in Endocrinology. 14, p. 1326768. https://doi.org/10.3389/fendo.2023.1326768

Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
Edward S. Wickstead, Bradley T. Elliott, Sarah Pokorny, Christopher Biggs, Stephen J. Getting and Simon McArthur 2023. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. International Journal of Molecular Sciences. 24 (21). https://doi.org/10.3390/ijms242115996

Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan
Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards and Bradley T. Elliott 2023. Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan. Antioxidants. 12 (9). https://doi.org/10.3390/antiox12091749

Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model
Allen, Sophie L., Elliott, Bradley T., Carson, Brian P. and Breen, Leigh 2023. Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model. American Journal of Physiology: Cell Physiology. 324 (2), pp. C420-C427. https://doi.org/10.1152/ajpcell.00473.2022

The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females
Bagheri, Reza, Ashtary-Larky, Damoon, Elliott, B., Willoughby, Darryn S., Kargarfard, Mehdi, Alipour, Meysam, Lamuchi-Deli, Nasrin, Kooti, Wesam, Asbaghi, Omid and Wong, Alexei 2023. The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females. Archives of Physiology and Biochemistry. 129 (3), pp. 821-828. https://doi.org/10.1080/13813455.2021.1874020

Editorial: Exercise as a Countermeasure to Human Aging, Volume II
Hayes, L., Burtscher, M. and Elliott, B. 2022. Editorial: Exercise as a Countermeasure to Human Aging, Volume II. Frontiers in Physiology. 13 (878983). https://doi.org/10.3389/fphys.2022.878983

Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men
Kyriakidou, Y., Cooper, I., Kraev, I., Lange, S. and Elliott, B. 2021. Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men. Frontiers in Physiology. 12 723931. https://doi.org/10.3389/fphys.2021.723931

High Intensity Interval Training (HIIT) as a Potential Countermeasure for Phenotypic Characteristics of Sarcopenia: A Scoping Review
Hayes, L., Elliott, B., Yasar, Z., Bampouras, T., Sculthorpe, N., Sanal-Hayes, N. and Hurst, C. 2021. High Intensity Interval Training (HIIT) as a Potential Countermeasure for Phenotypic Characteristics of Sarcopenia: A Scoping Review. Frontiers in Physiology. 12 715044. https://doi.org/10.3389/fphys.2021.715044

Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm.
Cooper, I., Brookler, Kenneth H, Kyriakidou, Yvoni, Elliott, B. and Crofts, C. 2021. Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm. Biomedicines. 9 (7) 800. https://doi.org/10.3390/biomedicines9070800

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males
Bagheri, R., Hooshmand Moghadam, B., Candow, D., Elliott, B., Wong, A., Ashtary-Larky, D., Forbes, S. and Rashidlamir, A. 2021. Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males. British Journal of Nutrition. 127 (9), pp. 1334-1342. https://doi.org/10.1017/S0007114521002166

Strategic Ingestion of High-Protein Dairy Milk during a Resistance Training Program Increases Lean Mass, Strength, and Power in Trained Young Males
Pourabbas, M., Bagheri, Reza, Hooshmand Moghadam, B., S. Willoughby, Darryn, G. Candow, Darren, Elliott, B., C. Forbes, S., Ashtary-Larky, Damoon, Eskandari, Mozhgan, Wong, Alexei and Dutheil, Frédéric 2021. Strategic Ingestion of High-Protein Dairy Milk during a Resistance Training Program Increases Lean Mass, Strength, and Power in Trained Young Males. Nutrients. 13 (3), p. e948. https://doi.org/10.3390/nu13030948

Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
Yasar, Z., Elliott, B., Kyriakidou, Y., Nwokoma, C., Postlethwaite, R., Gaffney, C., Dewhurst, S. and Hayes, L. 2021. Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men. European Journal of Applied Physiology. 121, pp. 1909-1919. https://doi.org/10.1007/s00421-021-04635-2

The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage
Kyriakidou, Y., Wood, C., Ferrier, C., Dolci, A. and Elliott, B. 2021. The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage. Journal of the International Society of Sports Nutrition. 18 (1) 9. https://doi.org/10.1186/s12970-020-00405-1

Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management
Cooper, I., Crofts, C., DiNicolantonio, J., Malhotra, A., Elliott, B., Kyriakidou, Y. and Brookler, K. 2020. Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management . Open Heart. 7 e001356. https://doi.org/10.1136/openhrt-2020-001356

"I've Seen You": A conversation about the Transformative Potential of Working in Partnership
Fraser, J., Usman, M., Thomas, K.C., Ahmed, M., Dolidze, A., Zuruwath Zareer, F., Begum, G., Elliott, B. and Macleod, E. 2020. "I've Seen You": A conversation about the Transformative Potential of Working in Partnership. in: Mercer-Mapstone, L. and Abbot, S. (ed.) The Power of Partnership: Students, Staff and Faculty Revolutionizing Higher Education Elon, North Carolina Elon University. pp. 205-219

Editorial: Exercise as a Countermeasure to Human Aging
Elliott, B., Hayes, L., Hughes, D. and Burtscher, M. 2020. Editorial: Exercise as a Countermeasure to Human Aging. Frontiers in Physiology. 11 883. https://doi.org/10.3389/fphys.2020.00883

Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners
Edwards, K., Elliott, B. and Silva, C. 2020. Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners. Journal of Sports Sciences. 38 (4), pp. 366-374. https://doi.org/10.1080/02640414.2019.1702269

Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men.
Bagheri, R., Rashidlamir, A., Motevalli, M., Elliott, B., Mehrabani, J. and Wong, A. 2019. Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men. European Journal of Applied Physiology. 119 (9), p. 1921–1931. https://doi.org/10.1007/s00421-019-04180-z

Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis
Hayes, L. and Elliott, B. 2019. Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis. Frontiers in Physiology. 9 1878. https://doi.org/10.3389/fphys.2018.01878

The Effect of Omega-3 Supplementation on Exercise-Induced Muscle Damage
Kyriakidou, Y., Wood, C., Elliott, B. and Dolci, A. 2018. The Effect of Omega-3 Supplementation on Exercise-Induced Muscle Damage. Europhysiology 2018. London 14 - 16 Sep 2018 The Physiological Society.

Activin subfamily peptides predict chronological age in humans
Barrios-Silva, L., Parnell, M., Shinwari, Z., Chaudhary, G., Xenofontos, T, van Bekhoven, A., McArthur, S. and Elliott, B. 2018. Activin subfamily peptides predict chronological age in humans. Physiological Report. 6 (17), p. e13823. https://doi.org/10.14814/phy2.13823

Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro
Kalampouka, I., van Bekhoven, A. and Elliott, B. 2018. Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro. Frontiers in Physiology. 9 152. https://doi.org/10.3389/fphys.2018.00152

High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals
Naufahu, J., Elliott, B., Markiv, A., Dunning-Foreman, P., McGrady, M., Howard, D., Watt, P.W. and Mackenzie, R.W.A. 2018. High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals. Journal of Clinical Endocrinology and Metabolism. 103 (4), pp. 1479-1490. https://doi.org/10.1210/jc.2017-02019

An automated panel for assessing pro-oxidant and antioxidant status in human serum
Ferrier, C., Reed, S.C. and Elliott, B. 2017. An automated panel for assessing pro-oxidant and antioxidant status in human serum.

PhytoCloud: A gamified Mobile Web Application to modulate diet and physical activity of women with breast cancer
Economou, D., Dwek, M., Elliott, B., Ramezanian Kalahroudi, M. and Azimi, T. 2017. PhytoCloud: A gamified Mobile Web Application to modulate diet and physical activity of women with breast cancer. IEEE 30th International Symposium on Computer-Based Medical Systems. Thessaloniki, Greece 22 Jun - 24 Sep 2017 IEEE . https://doi.org/10.1109/CBMS.2017.164

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation
Elliott, B., Herbert, P., Sculthorpe, N., Grace, F., Stratton, D. and Hayes, L. 2017. Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiological Report. 5 (13), p. e13343 e13343. https://doi.org/10.14814/phy2.13343

Circulating myostatin is reduced with aging in humans but not altered by short-term, high intensity training
Elliott, B., Shinwari, Z.B., Altayar, Z., Barrios, L., Chaudhary, G.A., Hanifa, E., Parnell, M., Xenofontos, T., Sculthorpe, N., Herbert, P., Grace, F. and Hayes, L. 2016. Circulating myostatin is reduced with aging in humans but not altered by short-term, high intensity training. Physiology 2016. Dublin, Ireland 29 2016 - 31 Jul 2017 The Physiological Society.

Complete and Voluntary Starvation of 50 days
Elliott, B., Mina, A. and Ferrier, C. 2016. Complete and Voluntary Starvation of 50 days. Clinical Medical Insights: Case Reports. 2016:9, pp. 67-70. https://doi.org/10.4137/CCRep.S39776

The role of acute ambient hypoxia in the regulation of myostatin
Elliott, B. 2015. The role of acute ambient hypoxia in the regulation of myostatin. PhD thesis University of Westminster Biomedical Sciences https://doi.org/10.34737/9ww8v

Wearable technology in academia: the use of Google Glass in the life sciences
Elliott, B. and Sukan, A. 2015. Wearable technology in academia: the use of Google Glass in the life sciences. Compass: Journal of Learning & Teaching . 6 (10).

Acute hypoxia reduces plasma myostatin independent of hypoxic dose
Elliott, B., Simonson, T.S., Getting, S.J., Renshaw, D., Wagner Peter, D. and MacKenzie, R. 2015. Acute hypoxia reduces plasma myostatin independent of hypoxic dose. 8th International Conference on Cachexia, Sarcopenia and Muscle Wasting. Paris 04 - 06 Dec 2015 The Society on Sarcopenia, Cachexia and Wasting Disorders.

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
MacKenzie, R. and Elliott, B. 2014. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 7, pp. 55-67. https://doi.org/10.2147/DMSO.S48260

What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems?
Fagan-Watson, B., Watson, T., Elliott, B., Vanner, R., Shaw, Ben and Morris, S. 2014. What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems? A report to the Department for Environment, Food and Rural Affairs. Policy Studies Institute. Defra, London.

Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo
Elliott, B., Renshaw, D., Getting, S.J., Watt, P.W. and MacKenzie, R. 2014. Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo. FASEB. San Diego Jul 2015 Federation of American Societies for Experimental Biology.

The role of acute hypoxia in skeletal muscle atrophy
Elliott, B., Renshaw, D., Getting, S.J., Watt, P., Howard, D. and MacKenzie, R. 2014. The role of acute hypoxia in skeletal muscle atrophy. Physiology. London 30 Jun 2014 The Physiological Society.

Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes
MacKenzie, R., Maxwell, N.S., Castle, P.C., Elliott, B., Brickley, G. and Watt, P.W. 2012. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (4), pp. 46-55. https://doi.org/10.1210/jc.2011-2829

The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B., Renshaw, D., Getting, S.J. and MacKenzie, R. 2012. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica. 205 (3), pp. 324-40. https://doi.org/10.1111/j.1748-1716.2012.02423.x

Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats
Legerlotz, K., Elliott, B., Guillemin, B. and Smith, H. 2008. Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats. Experimental Physiology. 93 (6), pp. 754-62. https://doi.org/10.1113/expphysiol.2007.041244

Permalink - https://westminsterresearch.westminster.ac.uk/item/qzwzy/comparable-endocrine-and-neuromuscular-adaptations-to-variable-vs-constant-gravity-dependent-resistance-training-among-young-women


Share this

Usage statistics

178 total views
68 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.