Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men : WestminsterResearch

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Title	Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
Type	Journal article
Authors	Yasar, Z., Elliott, B., Kyriakidou, Y., Nwokoma, C., Postlethwaite, R., Gaffney, C., Dewhurst, S. and Hayes, L.
Abstract	Purpose The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men. Methods Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group. Results Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL−1 and 60 (12) pg mL−1, respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL−1 which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07). Conclusion Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.
Keywords	Ageing
	Cytokines
	Exercise
	Growth factors
	HIIT
	Inflammation
Journal	European Journal of Applied Physiology
Journal citation	121, pp. 1909-1919
ISSN	1439-6327
Year	2021
Publisher	Springer
Accepted author manuscript	Yasar et al inflammation for archiving.docx License CC BY 4.0 File Access Level Open (open metadata and files)
Publisher's version	421_2021_Article_4635.pdf License CC BY 4.0 File Access Level Open (open metadata and files)
Digital Object Identifier (DOI)	https://doi.org/10.1007/s00421-021-04635-2
PubMed ID	33723630
Web address (URL)	https://link.springer.com/article/10.1007/s00421-021-04635-2
Published online	16 Mar 2021
Published in print	2021
Supplemental file	License CC BY 4.0 File Access Level Open (open metadata and files)

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Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

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