Molecular characterization of the melanocortin 3 receptor in the testes of mice

Horanin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F. 2009. Molecular characterization of the melanocortin 3 receptor in the testes of mice. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4).

TitleMolecular characterization of the melanocortin 3 receptor in the testes of mice
AuthorsHoranin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F.
JournalpA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society
Journal citation7 (4)
ISSN1741-1157
Year2009
PublisherBritish Pharmacological Society
Digital Object Identifier (DOI)doi:http://www.pa2online.org/abstracts/Vol7Issue4abst089P.pdf
Publication dates
Published2009

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The central role of myostatin in skeletal muscle and whole body homeostasis
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The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes
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Saliva: physiology and diagnostic potential in health and disease
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A13/BACII, a novel bovine chondrocytic cell line with differentiation potential
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Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: the protective effect on bovine articular chondrocytes following single impact trauma. Physiological Society Meeting 19. University of Manchester

REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma. Physiological Society Meeting 21. University of Durham

Circulating melanin concentrating hormone (MCH) concentrations in the menstrual cycle
Naufahu, J., Cunliffe, A. and Murray, J.F. 2010. Circulating melanin concentrating hormone (MCH) concentrations in the menstrual cycle. Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

Expression of endogenous and exogenous hypoxic markers in sheep preovulatory antral follicles
Murray, J.F., Gillies, R.M., Carter, N.D. and Robinson, S.P. 2010. Expression of endogenous and exogenous hypoxic markers in sheep preovulatory antral follicles. Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes
Kaneva, M., Locke, I.C., Kerrigan, M.J.P. and Getting, S.J. 2010. α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes. British Pharmacological Society Winter Meeting 2010. London, UK 14th-16th December 2010

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley. pp. PO136

The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. Physiology 2010. University of Manchester 30 June - 2 July 2010

Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3). Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis
Patel, H.B., Bombardieri, M., Sampaio, A.L.F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S.J., Pitzalis, C. and Perretti, M. 2010. Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis. FASEB Journal. 24 (12), pp. 4835-4843.

Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414.

Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. British Orthopaedic Research Society (BORS) Annual Meeting. Newcastle 22nd - 23rd June 2009

Utilising mitochondrial DNA markers to identify insects for forensic applications: an investigation into how the preservation and storage of insect tissue can affect mtDNA yield
Thompson, A., Tinworth, L. and Smith, C.L. 2009. Utilising mitochondrial DNA markers to identify insects for forensic applications: an investigation into how the preservation and storage of insect tissue can affect mtDNA yield. in: Proceedings of the 5th National FORREST Conference 2009 (FORensic RESearch and Teaching), 30th June – 1st July 2009, Liverpool John Moores University Forensic Institute Research Network and The Higher Education Academy Physical Sciences Centre. pp. 45

The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2009. The effects of REV5901 on chondrocyte viability following mechanical trauma. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4), p. P0149.

The antrums of ovine ovarian preovulatory follicles are severely hypoxic
Murray, J.F., Gillies, R.M., Carter, N.D. and Robinson, S.P. 2009. The antrums of ovine ovarian preovulatory follicles are severely hypoxic. Proceedings of the Society For Reproduction and Fertility Annual Conference. Oxford 12-14 July 2009 pp. 38

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society.

Identification of a sub-population of pituitary lactotroph cells in mice required for the normal luteotrophic function of prolactin
Jaubert, A., Fernadez-Fuente, M., Carmignac, D., Murray, J.F., Christain, H. and Le Tissier, P. 2009. Identification of a sub-population of pituitary lactotroph cells in mice required for the normal luteotrophic function of prolactin. ENDO2009. Washington 10-13 June 2009

Intraovarian changes associated with hypoxia during the rat oestrous cycle
Gillies, R.M., Carter, N.D., Robinson, S.P., McPhail, L.D. and Murray, J.F. 2009. Intraovarian changes associated with hypoxia during the rat oestrous cycle. National Ovarian Workshop. Fitzwilliam College, Cambridge 12-13 September 2009.

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Murray, J.F., Grieco, P., Getting, S.J. and Perretti, M. 2008. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB Journal. 22 (12), pp. 4228-4238.

A role for MC3R in modulating lung inflammation
Getting, S.J., Riffo-Vasquez, Y., Pitchford, S., Kaneva, M., Grieco, P., Page, C.P., Perretti, M. and Spina, D. 2008. A role for MC3R in modulating lung inflammation. Pulmonary Pharmacology and Therapeutics. 21 (6), pp. 866-873.

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. Superoxide production by eNOS
Crabtree, M.J., Smith, C.L., Lam, G., Goligorsky, M.S. and Gross, S.S. 2008. Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. Superoxide production by eNOS. American Journal of Physiology: Heart and Circulatory Physiology. 294 (4), pp. H1530-H1540.

Melanocortin 3 receptor in the testes of mice
Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. Society for Reproduction and Fertility. Edinburgh 29 Jun - 01 Jul 2008 pp. Abstract P80

Melanocortin 3 receptor in the testes of mice
Wotherspoon, G., Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. P008.

Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro
Stenbeck, G., Joseph, J., Getting, S.J. and Smith, C.L. 2008. Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C041.

The role of the actin cytoskeleton in chondrocyte protection following single impact
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2008. The role of the actin cytoskeleton in chondrocyte protection following single impact. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4).

Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor. Journal of Vascular Research. 45 (Suppl2).

Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation. William Harvey Day. St. Barts Hospital, London 14th October 2008

A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells
Getting, S.J., Kaneva, M. and Kerrigan, M.J.P. 2008. A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C020.

Melanocortins
Getting, S.J. 2008. Melanocortins. in: Offermanns, S. and Rosenthal, W. (ed.) Encyclopedia of molecular pharmacology. 2nd edition Berlin Springer. pp. 752-757

The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling
Ali, N., Getting, S.J. and Kerrigan, M.J.P. 2008. The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4).

Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, J.M., Nandi, M., Torondel, B., Murray-Rust, J., Malaki, M., O'Hara, B., Rossiter, S., Anthony, S., Madhani, M., Selwood, D.L., Smith, C.L., Wojciak-Stothard, B., Rudiger, A., Stidwill, R., McDonald, N.Q. and Vallance, P. 2007. Disruption of methylarginine metabolism impairs vascular homeostasis. Nature Medicine. 13 (2), pp. 198-203.

C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders?
Smith, C.L. 2007. C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders? Current Pharmaceutical Design. 13 (16), pp. 1619-1629.

Endogenous MC3R and inhibition of inflammatory arthritis. PC112
Patel, H.B., Sampaio, A.L.F., Getting, S.J., Gray, M. and Perretti, M. 2007. Endogenous MC3R and inhibition of inflammatory arthritis. PC112. Life Sciences. Glasgow 8th - 12th July 2007

Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106
Leoni, G., Getting, S.J., Gavins, F.N.E. and Perretti, M. 2007. Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106. Life Sciences. Glasgow 8th - 12th July 2007

Glucocorticoid and melanocortins: special issue
Getting, S.J. 2007. Glucocorticoid and melanocortins: special issue. ScientificWorldJournal. 7, pp. 1463-1464.

[D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse)
Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N.E., Grieco, P. and Perretti, M. 2006. [D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse). Molecular Pharmacology. 70 (6), pp. 1850-1855.

Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart
Gavins, F.N.E., Leoni, G. and Getting, S.J. 2006. Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart. ScientificWorldJournal. 6, pp. 1008-1023.

Targeting melanocortin receptors as potential novel therapeutics
Getting, S.J. 2006. Targeting melanocortin receptors as potential novel therapeutics. Pharmacology & Therapeutics. 111 (1), pp. 1-15.

Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors
Murray, J.F., Hahn, J.D., Kennedy, A.R., Small, C.J., Bloom, S.R., Haskell-Luevano, C., Coen, C.W. and Wilson, C.A. 2006. Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. Journal of Neuroendocrinology. 18 (3), pp. 157-167.

Melanocortin receptor signaling in RAW264.7 macrophage cell line
Lam, C.W., Perretti, M. and Getting, S.J. 2006. Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides. 27 (2), pp. 404-412.

The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
Getting, S.J., Di Filippo, C., D'Amico, M. and Perretti, M. 2006. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. European Journal of Pharmacology. 532 (1-2), pp. 138-144.

Mode of glucocorticoid actions in airway disease
Ito, K., Getting, S.J. and Charron, C.E. 2006. Mode of glucocorticoid actions in airway disease. ScientificWorldJournal. 28 (6), pp. 1750-1769.

Melanocortin 3 receptors control crystal-induced inflammation
Getting, S.J., Lam, C.W., Chen, A.S., Grieco, P. and Perretti, M. 2006. Melanocortin 3 receptors control crystal-induced inflammation. FASEB Journal. 20 (13), pp. 2234-2241.

Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary
Lea, R.G., Andrade, L.P., Rae, M.T., Hannah, L.T., Kyle, C.E., Murray, J.F., Rhind, S.M. and Miller, D.W. 2006. Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary. Reproduction. 131, pp. 113-124.

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA
Smith, C.L., Anthony, S., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. PLoS Medicine. 2 (10), pp. 1031-1043.

Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders
Smith, C.L. and Vallance, P. 2005. Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders. Current Pharmaceutical Design. 11 (17), pp. 2177-2185.

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, S., Smith, C.L., Malaki, M., Nandi, M., Gill, H., Leiper, J.M., Vallance, P. and Selwood, D.L. 2005. Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. Journal of Medicinal Chemistry. 48 (14), pp. 1670-1678.

Developmental indices of nutritionally induced placental growth restriction in the adolescent sheep
Lea, R.G., Hannah, L.T., Redmer, D.A., Aitken, R.P., Milne, J.S., Fowler, P.A., Murray, J.F. and Wallace, J.M. 2005. Developmental indices of nutritionally induced placental growth restriction in the adolescent sheep. Pediatric Research. 57 (4), pp. 599-604.

In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation
Lam, C.W., Getting, S.J. and Perretti, M. 2005. In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. Journal of Immunology. 174 (4), pp. 2297-2304.

Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels
Smith, C.L., Anthony, S., Malaki, M., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia
Nandi, M., Rossiter, S., Torondel, B., Malaki, M., Smith, C.L., Stidwill, R., Leiper, J.M. and Vallance, P. 2005. Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction. British Pharmaceutical Society Summer Meeting. Cambridge, UK 06-08 Jul 2005

Leptin expression in the fetus and placenta during mouse pregnancy
Malik, N.M., Carter, N.D., Wilson, C.A., Scaramuzzi, R.J., Stock, M.J. and Murray, J.F. 2005. Leptin expression in the fetus and placenta during mouse pregnancy. Placenta. 26 (1), pp. 47-52.

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M. and Perretti, M. 2004. MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Journal of Leukocyte Biology. 76 (4), pp. 845-853.

Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo
Cao, T.V., La, M., Getting, S.J. and Day, A.J. 2004. Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation. 11 (7), pp. 615-624.

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. Nitric Oxide: Biology and Chemistry. 11 (1), p. 59.

Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose. Nitric Oxide: Biology and Chemistry. 11 (1), p. 65.

Overexpression of dimethylarginine dimethylaminohydrolase enhances tumour hypoxia: an insight into the relationship of hypoxia and angiogenesis In vivo
Kostourou, V., Troy, H., Murray, J.F., Cullis, E.R., Whitley, G.S.J., Griffiths, J.R. and Robinson, S. 2004. Overexpression of dimethylarginine dimethylaminohydrolase enhances tumour hypoxia: an insight into the relationship of hypoxia and angiogenesis In vivo. NeoPlasia. 6 (4), pp. 401-411.

Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis
Getting, S.J., Di Filippo, C., Lam, C.W., Rossi, F. and D'Amico, M. 2004. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. Journal of Pharmacology and Experimental Therapeutics. 310 (1), pp. 90-97.

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
Yang, Y.H., Morand, E.F., Getting, S.J. and Paul-Clark, M. 2004. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis & Rheumatism. 50 (3), pp. 976-984.

The annexin 1-/- mouse: phenotypic studies
Wells, D., Wells, K., Liu, K., Hannon, R., Croxtall, J.D., Damazo, A.S., Oliani, S.M., Getting, S.J., Parente, L., Paul-Clark, M., Yona, S., Gavins, F.N.E., Martin, J., Christian, H.C., Cover, P.O., John, C.D., Solito, E., Morris, J.F., Perretti, M., Buckingham, J.C. and Flower, R.J. 2004. The annexin 1-/- mouse: phenotypic studies. Annexins. 1 (2), pp. 109-120.

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages
Lam, C.W., Getting, S.J. and Perretti, M. 2004. Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages. pA2 Online. Winter 2004 Meeting: Proceedings of the British Pharmacological Society.

Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy
Lam, C.W. and Getting, S.J. 2004. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Current Drug Targets. Inflammation & Allergy. 3 (3), pp. 311-315.

Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats
Murray, J.F., Dakin, C.L., Siddiqui, A., Pellatt, L.J., Ahmed, S., Ormerod, L.J.A., Swan, A.V., Davies, D.C. and Wilson, C.A. 2004. Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats. European Journal of Neuroscience. 19 (2), pp. 387-395.

Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype
Smith, C.L., Birdsey, G.M., Anthony, S., Arrigoni, F.I., Leiper, J.M. and Vallance, P. 2003. Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications. 308 (4), pp. 984-989.

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
Getting, S.J., Schiöth, H.B. and Perretti, M. 2003. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. 306 (2), pp. 631-637.

Central orexin A has site-specific effects on luteinizing hormone release in female rats
Small, C.J., Goubillon, M.L., Murray, J.F., Siddiqui, A., Grimshaw, S.E., Young, H., Sivanesan, V., Kalamatianos, T., Kennedy, A.R., Coen, C.W., Bloom, S.R. and Wilson, C.A. 2003. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology. 144 (7), pp. 3225-3236.

Measurement of cardiac troponin I in striated muscle using three experimental methods
Fredericks, S., Bainbridge, K., Murray, J.F., Collinson, P.O., Carter, N.D. and Holt, D.W. 2003. Measurement of cardiac troponin I in striated muscle using three experimental methods. Annals of Clinical Biochemistry. 40 (3), pp. 244-248.

Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor
Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N.E., Flower, R.J., Schiöth, H.B. and Perretti, M. 2003. Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. Journal of Immunology. 170 (6), pp. 3323-3330.

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
Hannon, R., Croxtall, J.D., Getting, S.J., Roviezzo, F., Yona, S., Paul-Clark, M., Gavins, F.N.E., Perretti, M., Morris, J.F., Buckingham, J.C. and Flower, R.J. 2003. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB Journal. 17 (2), pp. 253-255.

Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. Methods in Molecular Biology. 225, pp. 139-146.

Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo. in: Winyard, P.G. and Willoughby, D.A. (ed.) Inflammation Protocols Totowa, NJ Humana Press. pp. 139-146

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner
Getting, S.J., Mahoney, D.J., Cao, T.V., Rugg, M.S., Fries, E., Milner, C.M., Perretti, M. and Day, A.J. 2002. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. Journal of Biological Chemistry. 277 (52), pp. 51068-51076.

The annexin-1 knockout mouse: what it tells us about the inflammatory response
Roviezzo, F., Getting, S.J., Paul-Clark, M., Yona, S., Gavins, F.N.E., Perretti, M., Hannon, R., Croxtall, J.D., Buckingham, J.C. and Flower, R.J. 2002. The annexin-1 knockout mouse: what it tells us about the inflammatory response. Journal of Physiology and Pharmacology. 53 (4, part 1), pp. 541 -553.

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Perretti, M., Chiang, N., La, M., Fierro, I.M., Marullo, S., Getting, S.J., Solito, E. and Serhan, C.N. 2002. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nature Medicine. 8 (11), pp. 1296-1302.

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
Getting, S.J., Christian, H.C., Flower, R.J. and Perretti, M. 2002. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis & Rheumatism. 46 (10), pp. 2765-2775.

Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy
Getting, S.J. 2002. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends in Pharmacological Sciences. 23 (10), pp. 447-449.

Cardiac troponin T and creatine kinase MB content in skeletal muscle of the uremic rat
Fredericks, S., Murray, J.F., Carter, N.D., Chesser, A.M.S., Papachristou, S., Yaqoob, M.M., Collinson, P.O., Gaze, D. and Holt, D.W. 2002. Cardiac troponin T and creatine kinase MB content in skeletal muscle of the uremic rat. Clinical Chemistry. 48 (6), pp. 859-868.

A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones
Malcangio, M., Getting, S.J., Grist, J., Cunningham, J.R., Bradbury, E.J., Issa, P.C., Lever, I.J., Pezet, S. and Perretti, M. 2002. A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB Journal. 16 (7), pp. 730-732.

The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology
Jones, C.L., Vasquez-Vivar, J., Kalyanaraman, B., Griscavage-Ennis, J.M., Gross, S.S. and Smith, C.L. 2002. The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology. in: Milstien, S., Kapatos, G., Levine, R.A. and Shane, B. (ed.) Chemistry and biology of pteridines and folates: proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, M.D. Boston, USA Kluwer Academic Publishers. pp. 271-276

Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma
Carollo, M., Getting, S.J., Delaney, S., Christie, M.I. and Perretti, M. 2002. Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma. Inflammation Research. 51 (2), pp. 110-111.

Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding
Weissman, B.A., Jones, C.L., Liu, Q., Gross, S.S. and Smith, C.L. 2002. Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding. European Journal of Pharmacology. 435 (1), pp. 9-18.

Leptin requirement for conception, implantation, and gestation in the mouse
Malik, N.M., Carter, N.D., Murray, J.F., Scaramuzzi, R.J., Wilson, C.A. and Stock, M.J. 2001. Leptin requirement for conception, implantation, and gestation in the mouse. Endocrinology. 142 (12), pp. 5198-5202.

Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti, M., Getting, S.J., Solito, E., Murphy, P.M. and Gao, J.L. 2001. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. American Journal of Pathology. 158 (6), pp. 1969-1973.

Cardiac troponin T and creatine kinase MB are not increased in exterior oblique muscle of patients with renal failure
Fredericks, S., Murray, J.F., Bewick, M., Chang, R., Collinson, P.O., Carter, N.D. and Holt, D.W. 2001. Cardiac troponin T and creatine kinase MB are not increased in exterior oblique muscle of patients with renal failure. Clinical Chemistry. 47 (6), pp. 1023-1030.

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Mabley, J.G., Jagtap, P., Perretti, M., Getting, S.J., Salzman, A.L., Virag, L., Szabo, E., Soriano, F.G., Liaudet, L., Hasko, G., Marton, A., Southan, G.J., Abdelkarim, G.E. and Szabo, C. 2001. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation Research. 50 (11), pp. 561-569.

Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics
Getting, S.J. and Perretti, M. 2001. Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current opinion in investigational drugs. 2 (8), pp. 1064-1069.

Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
Getting, S.J., Allcock, G.H., Flower, R.J. and Perretti, M. 2001. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. Journal of Leukocyte Biology. 69 (1), pp. 98-104.

MC3-R as a novel target for anti-inflammatory therapy
Getting, S.J. and Perretti, M. 2000. MC3-R as a novel target for anti-inflammatory therapy. Drug News & Perspectives. 13 (1), pp. 19-27.

POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
Getting, S.J., Gibbs, L., Clark, A.J.L., Flower, R.J. and Perretti, M. 1999. POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology. 162 (12), pp. 7446-7453.

Compounds for use in the treatment of inflammation
Flower, R.J., Getting, S.J. and Perretti, M. 1998. Compounds for use in the treatment of inflammation.

An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase
Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M.E., Martasek, P., Roman, L.J., Masters, B.S.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., Gross, S.S. and Smith, C.L. 1997. An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. Journal of Biological Chemistry. 272 (47), pp. 29769-29777.

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects
Szabo, C., Lim, L.H.K., Cuzzocrea, S., Getting, S.J., Zingarelli, B., Flower, R.J., Salzman, A.L. and Perretti, M. 1997. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of experimental medicine. 186 (7), pp. 1041-1049.

Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
Getting, S.J., Flower, R.J., Parente, L., de Medicis, R., Lussier, A., Woliztky, B.A., Martins, M.A. and Perretti, M. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics. 283 (1), pp. 123-130.

Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1
Getting, S.J., Flower, R.J. and Perretti, M. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology. 120 (6), pp. 1075-1082.

Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes
Tailor, A., Das, A.M., Getting, S.J., Flower, R.J. and Perretti, M. 1997. Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications. 231 (3), pp. 675-678.

Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199.

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104.

Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo
Segieth-Beever, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo. Wiley.

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