Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. Superoxide production by eNOS

Evaluating the benefits of virtual training for bioscience students
Coleman, S.K. and Smith, C.L. 2019. Evaluating the benefits of virtual training for bioscience students. Higher Education Pedagogies. doi:10.1080/23752696.2019.1599689

Employer and work-based student perceptions of virtual laboratory teaching and assessment resources
Smith, C.L., Coleman, S.K. and Ferrier, C. 2019. Employer and work-based student perceptions of virtual laboratory teaching and assessment resources. Work Based Learning e-Journal International. 8 (1), pp. 53-70.

Melanocortin‐3 receptor responseis influenced by the melanocortin receptoraccessory protein‐1
Berruien, N., Le Tissier, P., Murray, J.F. and Smith, C.L. 2018. Melanocortin‐3 receptor responseis influenced by the melanocortin receptoraccessory protein‐1. Pharmacology 2018. Queen Elizabeth II conference centre London 18 - 20 Dec 2018 Wiley-Blackwell. doi:10.1111/bph.14681

Student experiences of using virtual laboratory simulations to develop skills as preparation for the professional work place
Buckland, E., Smith, C.L. and Ferrier, C. 2018. Student experiences of using virtual laboratory simulations to develop skills as preparation for the professional work place. Creating Relevant Learning Experiences; employers ’ involvement with higher education. Leuven, Belgium 14 - 15 Jun 2018

Evaluating the benefits of virtual training for students
Coleman, S.K. and Smith, C.L. 2018. Evaluating the benefits of virtual training for students. Westminster Learning and Teaching Symposium. London, UK 26 Jun 2018

Employer and part-time student perceptions of virtual laboratory teaching and assessment resources
Smith, C.L., Ferrier, C. and Coleman, S.K. 2018. Employer and part-time student perceptions of virtual laboratory teaching and assessment resources. Creating Relevant Learning Experiences; employers ’ involvement with higher education. Leuven, Belgium 14 - 15 Jun 2018

Using virtual reality laboratories to improve engagement and understanding for wet laboratory practical sessions
Coleman, S.K., Smith, C.L. and Ferrier, C. 2018. Using virtual reality laboratories to improve engagement and understanding for wet laboratory practical sessions. Society for Experimental Biology: Masters of Biology. Florence, Italy 03 - 06 Jul 2018

Analysis of the melanocortin system in the regulation of pituitary gland function in mice
Le Tissier, P., Smith, C.L., Nuri A. Berruien, N. and Murray, J.F. 2018. Analysis of the melanocortin system in the regulation of pituitary gland function in mice. International Congress of Neuroendocinology. Toronto, Canada 15 - 18 Jul 2018

Evaluating the benefits of virtual training for bioscience students
Smith, C.L. and Coleman, S.K. 2018. Evaluating the benefits of virtual training for bioscience students. Annual STEM Conference 2018 Creativity in Teaching, Learning and Student Engagement. Newcastle-upon-Tyne 31 Jan - 01 Feb 2018 Higher Education Academy.

Using virtual reality to prepare Bioscience students for practical classes
Coleman, S.K., Volpi, E. and Smith, C.L. 2017. Using virtual reality to prepare Bioscience students for practical classes. 16th Westminster Symposium Innovate!. University of Westminster, London 22 - 22 Jun 2017

Increasing accessibility of students to laboratory classes through the use of Virtual laboratory simulations
Smith, C.L. and Coleman, S.K. 2017. Increasing accessibility of students to laboratory classes through the use of Virtual laboratory simulations . UALL Work and Learning Network Annual Conference 2017 - Leading the Way: Shaping Practice in the Workplace and the Academy.. Middlesex University 23 - 23 Jun 2017

Using Labster to improve Bioscience student learning and engagement in practical classes
Smith, C.L. and Coleman, S.K. 2017. Using Labster to improve Bioscience student learning and engagement in practical classes. Heads of Biological Sciences, Royal Society of Biology. Spring 2017 meeting.. University of Leicester 10 - 11 May 2017

In silico and in vitro approaches to develop Dimethylarginine dimethylaminohydrolase-1 inhibitors
Smith, C.L., Zloh, M. and Rossiter, S. 2017. In silico and in vitro approaches to develop Dimethylarginine dimethylaminohydrolase-1 inhibitors. Kendall, D. (ed.) In silico and in vitro methods in modern drug discovery. University of Nottingham 24 - 25 Apr 2017 British Pharmacological Society.

Effect of age and pregnancy on the expression of melanocortin receptors 4 and 5 in the mouse female reproductive axis
Smith, C.L., Nuri A. Berruien, N., Murray, J.F. and Le Tissier, P.R. 2016. Effect of age and pregnancy on the expression of melanocortin receptors 4 and 5 in the mouse female reproductive axis. BPS Pharmacology 2016. London, UK 12 - 14 Dec 2016 British Pharmacological Society.

Next generation e-learning platform: virtual laboratory simulations
Smith, C.L. and Markiv, A. 2016. Next generation e-learning platform: virtual laboratory simulations. Heads of Biological Sciences, Royal Society of Biology, Spring 2016. University of Leicester 04 - 05 May 2016

An investigation into the impact of peer- and self-marking in a first year biochemistry module
Smith, C.L. 2016. An investigation into the impact of peer- and self-marking in a first year biochemistry module. Inspire to succeed: Transforming teaching and learning in STEM. East Midlands Conference Centre, Nottingham on 28 and 29 January 2016 28 Jan 2016

Curriculum and beyond: Mathematics support for first year life science students
Bailey, I., Ferrier, C. and Smith, C.L. 2015. Curriculum and beyond: Mathematics support for first year life science students. CETL-MSOR Conference 2015. University of Greenwich 08 Sep 2015 The Sigma Network.

Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C
Smith, C.L., Shah, C.M., Kamaludin, N. and Gordge, M.P. 2015. Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C. Thrombosis Research. 135 (4), p. 748–753. doi:10.1016/j.thromres.2015.01.034

The melanocortin system in the male reproductive axis
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. The melanocortin system in the male reproductive axis. Endocrine Abstracts. 34, p. P338. doi:10.1530/endoabs.34.P338

Melanocortin receptor expression in the hypothalamo-pituitary-gonadal system of WT and MC3 null mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. Melanocortin receptor expression in the hypothalamo-pituitary-gonadal system of WT and MC3 null mice. International Congress of Neuroendocrinology 2014. Sydney 17-20 August 2014

Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells. Society for Reproduction and Fertility Conference. EICC2, Edinburgh 1-2 September 2014

An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
Opoku-Okrah, C., Gordge, M.P., Kweku Nakua, E., Abgenyega, T., Parry, M., Robertson, C.E. and Smith, C.L. 2014. An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana. International Journal of Laboratory Haematology. 36 (1), pp. 62-70. doi:10.1111/ijlh.12122

Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C., Keshavarz, T. and Roy, I. 2013. Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive and Functional Polymers. 73 (10), pp. 1340-1348. doi:10.1016/j.reactfunctpolym.2013.03.019

Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C. and Roy, I. 2013. Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents. Bioinspired, Biomimetic and Nanobiomaterials. 2 (3), pp. 141-153. doi:10.1680/bbn.13.00009

On - track: A Change Academy project investigating student attendance and engagement
Smith, C.L., Benson, N., Reilly, A.M., Allen, J., Clements, M.O., Shacklady, D., Davies, P., Bacquet, S. and Umeh, K. 2013. On - track: A Change Academy project investigating student attendance and engagement. 12th Annual Westminster Learning and Teaching Symposium. 04 Jul 2013

The role of cancer stem cells in osteosarcoma
Jenks, A., Smith, C.L., Patel, V. and Clements, M.O. 2013. The role of cancer stem cells in osteosarcoma. International society for stem cell research conference. Boston (Massachusetts, USA) June 12 – 15 2013

Melanocortin 3 receptor (MC3) activation effects on testicular testosterone and nitrite production in vitro
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2013. Melanocortin 3 receptor (MC3) activation effects on testicular testosterone and nitrite production in vitro. Society for Reproduction and Fertility (SRF) Annual Conference. Cambridge 11th July 2013

Recovery of DNA from coloured fabrics: a study into the effects of clothing dye contamination on the recovery and amplification of DNA
Bux, U., Mubarakku, S., Bennett-Cadette, C. and Smith, C.L. 2013. Recovery of DNA from coloured fabrics: a study into the effects of clothing dye contamination on the recovery and amplification of DNA. 9th National FORREST Conference 2013 (FORensic RESearch and Teaching). Anglia Ruskin University 25-26th June 2013

Expression of melanocortin 3 receptors (MC3) in the reproductive axes of both male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2012. Expression of melanocortin 3 receptors (MC3) in the reproductive axes of both male and female mice. Society for Reproduction and Fertility. Edinburgh 9th - 11th July 2012

Novel biodegradable and biocompatible poly(3-hydroxyoctanoate)/bacterial cellulose composites
Basnett, P., Knowles, J.C., Pishbin, F., Smith, C.L., Keshavarz, T., Boccaccini, A.R. and Roy, I. 2012. Novel biodegradable and biocompatible poly(3-hydroxyoctanoate)/bacterial cellulose composites. Advanced Engineering Materials. 14 (6), pp. B330-B343. doi:10.1002/adem.201180076

Alpha thalassaemia and the severity of Plasmodium falciparum infection in microcytic children from the Ashanti region of Ghana
Opoku-Okrah, C., Smith, C.L., Gordge, M.P., Parry, M., Robertson, C.E., Abgenyega, T. and Nakua, E. 2012. Alpha thalassaemia and the severity of Plasmodium falciparum infection in microcytic children from the Ashanti region of Ghana. British Society for Haematology 52nd meeting. Glasgow 16-18 April 2012

A comparison of novel NG, NG-disubstituted arginines on recombinant dimethylarginine dimethylaminohydrolase-1 activity and nitrite production in RAW264.7 macrophages
Morfill, C., Rossiter, S. and Smith, C.L. 2012. A comparison of novel NG, NG-disubstituted arginines on recombinant dimethylarginine dimethylaminohydrolase-1 activity and nitrite production in RAW264.7 macrophages. Proceedings of the British Pharmacological Society. 10 (4).

Polyhydroxyalkanoate (PHA): bacterial cellulose composites for biomedical applications
Basnett, P., Smith, C.L., Boccaccini, A.R., Knowles, J.C., Keshavarz, T. and Roy, I. 2011. Polyhydroxyalkanoate (PHA): bacterial cellulose composites for biomedical applications. European Society of Biomaterials. Dublin, Ireland Sept 2011

Total pituitary hormone content in wild type and MC3 null male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Perretti, M., Le Tissier, P. and Murray, J.F. 2011. Total pituitary hormone content in wild type and MC3 null male and female mice. British Society for Neuroendocrinology. Cambridge 3rd - 5th July 2011

Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Perretti, M., Le Tissier, P. and Murray, J.F. 2011. Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice. Society for Reproduction and Fertility. Brighton 11th - 13th July 2011

Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production. Society for Endocrinology BES 2010. Manchester 15th - 18th March 2010

Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3). Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

Utilising mitochondrial DNA markers to identify insects for forensic applications: an investigation into how the preservation and storage of insect tissue can affect mtDNA yield
Thompson, A., Tinworth, L. and Smith, C.L. 2009. Utilising mitochondrial DNA markers to identify insects for forensic applications: an investigation into how the preservation and storage of insect tissue can affect mtDNA yield. in: Proceedings of the 5th National FORREST Conference 2009 (FORensic RESearch and Teaching), 30th June – 1st July 2009, Liverpool John Moores University Forensic Institute Research Network and The Higher Education Academy Physical Sciences Centre. pp. 45

Molecular characterization of the melanocortin 3 receptor in the testes of mice
Horanin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F. 2009. Molecular characterization of the melanocortin 3 receptor in the testes of mice. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4). doi:http://www.pa2online.org/abstracts/Vol7Issue4abst089P.pdf

Melanocortin 3 receptor in the testes of mice
Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. Society for Reproduction and Fertility. Edinburgh 29 Jun - 01 Jul 2008 pp. Abstract P80

Melanocortin 3 receptor in the testes of mice
Wotherspoon, G., Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. P008.

Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro
Stenbeck, G., Joseph, J., Getting, S.J. and Smith, C.L. 2008. Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C041.

Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, J.M., Nandi, M., Torondel, B., Murray-Rust, J., Malaki, M., O'Hara, B., Rossiter, S., Anthony, S., Madhani, M., Selwood, D.L., Smith, C.L., Wojciak-Stothard, B., Rudiger, A., Stidwill, R., McDonald, N.Q. and Vallance, P. 2007. Disruption of methylarginine metabolism impairs vascular homeostasis. Nature Medicine. 13 (2), pp. 198-203. doi:10.1038/nm1543

C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders?
Smith, C.L. 2007. C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders? Current Pharmaceutical Design. 13 (16), pp. 1619-1629.

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA
Smith, C.L., Anthony, S., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. PLoS Medicine. 2 (10), pp. 1031-1043. doi:10.1371/journal.pmed.0020264

Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders
Smith, C.L. and Vallance, P. 2005. Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders. Current Pharmaceutical Design. 11 (17), pp. 2177-2185. doi:10.2174/1381612054367364

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, S., Smith, C.L., Malaki, M., Nandi, M., Gill, H., Leiper, J.M., Vallance, P. and Selwood, D.L. 2005. Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. Journal of Medicinal Chemistry. 48 (14), pp. 1670-1678. doi:10.1021/jm050187a

Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels
Smith, C.L., Anthony, S., Malaki, M., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia
Nandi, M., Rossiter, S., Torondel, B., Malaki, M., Smith, C.L., Stidwill, R., Leiper, J.M. and Vallance, P. 2005. Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction. British Pharmaceutical Society Summer Meeting. Cambridge, UK 06-08 Jul 2005

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. Nitric Oxide: Biology and Chemistry. 11 (1), p. 59. doi:10.1016/j.niox.2004.07.003

Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose. Nitric Oxide: Biology and Chemistry. 11 (1), p. 65. doi:10.1016/j.niox.2004.07.003

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype
Smith, C.L., Birdsey, G.M., Anthony, S., Arrigoni, F.I., Leiper, J.M. and Vallance, P. 2003. Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications. 308 (4), pp. 984-989. doi:10.1016/S0006-291X(03)01507-9

The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology
Jones, C.L., Vasquez-Vivar, J., Kalyanaraman, B., Griscavage-Ennis, J.M., Gross, S.S. and Smith, C.L. 2002. The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology. in: Milstien, S., Kapatos, G., Levine, R.A. and Shane, B. (ed.) Chemistry and biology of pteridines and folates: proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, M.D. Boston, USA Kluwer Academic Publishers. pp. 271-276

Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding
Weissman, B.A., Jones, C.L., Liu, Q., Gross, S.S. and Smith, C.L. 2002. Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding. European Journal of Pharmacology. 435 (1), pp. 9-18. doi:10.1016/S0014-2999(01)01560-6

Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS
Thorup, C., Jones, C.L., Gross, S.S., Moore, L.C. and Goligorsky, M.S. 1999. Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. American journal of physiology. 277 (6), pp. F882-F889.

An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase
Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M.E., Martasek, P., Roman, L.J., Masters, B.S.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., Gross, S.S. and Smith, C.L. 1997. An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. Journal of Biological Chemistry. 272 (47), pp. 29769-29777.