Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA

Smith, C.L., Anthony, S., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. PLoS Medicine. 2 (10), pp. 1031-1043.

TitleEffects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA
AuthorsSmith, C.L., Anthony, S., Hubank, M., Leiper, J.M. and Vallance, P.
Abstract

Background: Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Clinical studies implicate plasma ADMA as a major novel

cardiovascular risk factor, but the mechanisms by which low concentrations of ADMA produce adverse effects on the cardiovascular system are unclear.

Methods and Findings: We treated human coronary artery endothelial cells with pathophysiological concentrations

of ADMA and assessed the effects on gene expression using U133A GeneChips (Affymetrix). Changes in several genes, including bone morphogenetic protein 2 inducible kinase (BMP2K), SMA-related protein 5 (Smad5), bone morphogenetic protein receptor 1A, and protein arginine methyltransferase 3 (PRMT3; also known as HRMT1L3), were confirmed by Northern blotting, quantitative PCR, and in some instances Western blotting analysis to detect changes in protein

expression. To determine whether these changes also occurred in vivo, tissue from gene deletion mice with raised ADMA levels was examined. More than 50 genes were significantly altered in endothelial cells after treatment with pathophysiological concentrations of ADMA (2 lM). We detected specific patterns of changes that identify pathways involved in processes relevant to cardiovascular risk and pulmonary hypertension. Changes in BMP2K and PRMT3

were confirmed at mRNA and protein levels, in vitro and in vivo.

Conclusion: Pathophysiological concentrations of ADMA are sufficient to elicit significant changes in coronary artery endothelial cell gene expression. Changes in bone morphogenetic protein signalling, and in enzymes involved in arginine methylation, may be particularly relevant to

understanding the pathophysiological significance of raised ADMA levels. This study identifies the mechanisms by which increased ADMA may contribute to common cardiovascular diseases and thereby indicates possible targets for therapies.

JournalPLoS Medicine
Journal citation2 (10), pp. 1031-1043
ISSN1549-1277
YearOct 2005
FileSmith_Anthony_Hubank_et_al_2005_final.pdf
Digital Object Identifier (DOI)doi:10.1371/journal.pmed.0020264
Web address (URL)http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1240048
Publication dates
PublishedOct 2005

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