An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

Opoku-Okrah, C., Gordge, M.P., Kweku Nakua, E., Abgenyega, T., Parry, M., Robertson, C.E. and Smith, C.L. 2014. An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana. International Journal of Laboratory Haematology. 36 (1), pp. 62-70.

TitleAn investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
AuthorsOpoku-Okrah, C., Gordge, M.P., Kweku Nakua, E., Abgenyega, T., Parry, M., Robertson, C.E. and Smith, C.L.
Abstract

Introduction:

Several factors influence the severity of Plasmodium falciparum; here, we investigate the impact of alpha+-thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana.

Methods:

Seven hundred and thirty-two children (≤10 years) with P. falciparum were categorised into normocytic and microcytic (mean cell volume ≤76 fL). Microcytic individuals were genotyped for the −α3.7deletional thalassaemia mutation and parasite densities determined.

Results:

Amongst microcytic patients both parasite densities and prevalence of severe malaria parasitemia (≥100 000/μL) were significantly lower (P < 0.001) in the presence of an alpha+-thalassaemia genotype compared with non-alpha+-thalassaemia genotype. There was no evidence that alpha+-thalassaemia protected against severe anaemia. The protection conferred by alpha-thalassaemia genotype against severe P. falciparum parasitemia did not change with increasing age.

Conclusion:

The severity of P. falciparum parasitemia was significantly lower in both the homozygous and heterozygous alpha+-thalassaemia groups compared with microcytic individuals with non-alpha+-thalassaemia genotype. The protective effect, from severe malaria, of the alpha+-thalassaemia allele does not alter with age.

JournalInternational Journal of Laboratory Haematology
Journal citation36 (1), pp. 62-70
ISSN1751-553X
Year2014
PublisherWiley
Digital Object Identifier (DOI)doi:10.1111/ijlh.12122
Publication dates
PublishedFeb 2014

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Megakaryocyte apoptosis: sorting out the signals
Gordge, M.P. 2005. Megakaryocyte apoptosis: sorting out the signals. British Journal of Pharmacology. 145 (3), pp. 271-273.

Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels
Smith, C.L., Anthony, S., Malaki, M., Hubank, M., Leiper, J.M. and Vallance, P. 2005. Pathophysiological concentrations of ADMA alter human coronary artery endothelial cell gene expression: an insight into the pathophysiological significance of raised plasma ADMA levels. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes
Shah, C.M., Walters, S.E., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2005. Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes. Ireland-UK Platelet Conference 2005. Dublin, Ireland 04-06 Sep 2005

Salt intake and cardiovascular health in adults: analysis of INTERMAP study and NDNS
Robertson, C.E., Hurley, J. and Elliott, P. 2005. Salt intake and cardiovascular health in adults: analysis of INTERMAP study and NDNS. London, UK Food Standards Agency.

Post-market surveillance of novel foods
Robertson, C.E. 2005. Post-market surveillance of novel foods. Food Science & Technology. 19 (2), pp. 35-37.

Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia
Nandi, M., Rossiter, S., Torondel, B., Malaki, M., Smith, C.L., Stidwill, R., Leiper, J.M. and Vallance, P. 2005. Potential therapeutic benefit of novel DDAH inhibitors for the treatment of endotoxemia. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Evidence of systemic and pulmonary endothelial dysfunction in the Dimethylarginine Dimethylaminohydrolase I (DDAH I+/-) heterozygous knockout mouse. in: Boger, R., Fleming, I. and Waltenberger, J. (ed.) Vascular Biology and Medicine: 3rd European Meeting, Hamburg, September 2005, abstracts Germany Karger.

Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction
Malaki, M., Nandi, M., Madhani, M., Gill, H., Smith, C.L., Leiper, J.M. and Vallance, P. 2005. Dimethylarginine dimethylaminohydrolase I (DDAH I) heterozygous knockout mice display a cardiovascular phenotype consisting of pulmonary and systemic endothelial dysfunction. British Pharmaceutical Society Summer Meeting. Cambridge, UK 06-08 Jul 2005

Book review: When food kills: BSE, E coli and disaster science
Robertson, C.E. 2005. Book review: When food kills: BSE, E coli and disaster science. Journal of Epidemiology & Community Health. 59 (3), p. 250.

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. Nitric Oxide: Biology and Chemistry. 11 (1), p. 59.

Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxy-L-arginine in endothelial cells with NO deficiency triggered by elevated glucose. Nitric Oxide: Biology and Chemistry. 11 (1), p. 65.

Standardised coding of diet records: experiences from INTERMAP UK
Conway, R., Robertson, C.E., Dennis, B.H., Stamler, J. and Elliott, P. 2004. Standardised coding of diet records: experiences from INTERMAP UK. British Journal of Nutrition. 91 (5), pp. 765-771.

Effects of low dose ADMA on gene expression in human coronary artery endothelial cells
Smith, C.L., Leiper, J.M. and Vallance, P. 2004. Effects of low dose ADMA on gene expression in human coronary artery endothelial cells. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Cell surface thiol modification by GSNO: a mechanism of nitric oxide delivery?
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Cell surface thiol modification by GSNO: a mechanism of nitric oxide delivery? 5th UK Nitric Oxide Forum. Edinburgh, UK 12/2004

Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. Japan-UK Platelet Conference. Oxford, UK September 2004

Surveillance and post market monitoring of potential health effects of novel (including GM) foods: feasibility study
Elliott, P., Robertson, C.E., Diamond, J. and Best, N. 2004. Surveillance and post market monitoring of potential health effects of novel (including GM) foods: feasibility study. London, UK Food Standards Agency.

Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose
Crabtree, M.J., Smith, C.L. and Gross, S.S. 2004. Restoration of nitric oxide production by N-hydroxyarginine in endothelial cells with NO deficiency triggered by elevated glucose. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004

Rapid S-nitrosothiol metabolism by platelets and megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2003. Rapid S-nitrosothiol metabolism by platelets and megakaryocytes. Biochemical Society Transactions. 31 (6), pp. 1450-1452.

Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study
Zhou, B.F., Stamler, J., Dennis, B.H., Moag-Stahlberg, A., Okuda, N., Robertson, C.E., Zhao, L., Chan, Q. and Elliott, P. 2003. Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study. Journal of Human Hypertension. 17 (9), pp. 623-630.

Higher blood pressure in middle-aged American adults with less education - role of multiple dietary factors: the INTERMAP study
Stamler, J., Elliott, P., Appel, L.J., Chan, Q., Buzzard, M., Dennis, B.H., Dyer, A.R., Elmer, P.J., Greenland, P., Jones, D., Kesteloot, H., Kuller, L., Labarthe, D., Liu, K., Moag-Stahlberg, A., Nichaman, M., Okayama, A., Okuda, N., Robertson, C.E., Rodriguez, B.L., Stevens, M., Ueshima, H., Van Horn, L. and Zhou, B.F. 2003. Higher blood pressure in middle-aged American adults with less education - role of multiple dietary factors: the INTERMAP study. Journal of Human Hypertension. 17 (9), pp. 655-664.

Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype
Smith, C.L., Birdsey, G.M., Anthony, S., Arrigoni, F.I., Leiper, J.M. and Vallance, P. 2003. Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications. 308 (4), pp. 984-989.

INTERMAP: the dietary data - process and quality control
Dennis, B.H., Stamler, J., Buzzard, M., Conway, R., Elliott, P., Moag-Stahlberg, A., Okayama, A., Okuda, N., Robertson, C.E., Robinson, F., Schakel, S.F., Stevens, M., Van Heel, N., Zhao, L. and Zhou, B.F. 2003. INTERMAP: the dietary data - process and quality control. Journal of Human Hypertension. 17 (9), pp. 609-622.

Enhancing data on nutrient composition of foods eaten by participants in the INTERMAP study in China, Japan, the United Kingdom, and the United States
Schakel, S.F., Dennis, B.H., Wold, A.C., Conway, R., Zhao, L., Okuda, N., Okayama, A., Moag-Stahlberg, A., Robertson, C.E., Van Heel, N., Buzzard, M. and Stamler, J. 2003. Enhancing data on nutrient composition of foods eaten by participants in the INTERMAP study in China, Japan, the United Kingdom, and the United States. Journal of Food Composition and Analysis. 16 (3), pp. 395-408.

Tracing ingestion of 'novel' foods in UK diets for possible health surveillance: a feasibility study
Robertson, C.E., Best, N., Diamond, J. and Elliott, P. 2003. Tracing ingestion of 'novel' foods in UK diets for possible health surveillance: a feasibility study. Public Health Nutrition. 7 (2), pp. 345-352.

Role of protein disulphide isomerase in NO delivery from S-nitrosothiols into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2003. Role of protein disulphide isomerase in NO delivery from S-nitrosothiols into megakaryocytes. 4th UK Nitric Oxide Forum. University of Nottingham, UK December 2003

Book review: McCance and Widdowson's the composition of foods - sixth summary edition
Robertson, C.E. 2003. Book review: McCance and Widdowson's the composition of foods - sixth summary edition. Nutrition Bulletin. 28 (1), pp. 81-83.

Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells
Khand, F.D., Gordge, M.P., Robertson, W.G., Noronha-Dutra, A. and Hothersall, J. 2002. Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells. Free Radical Biology & Medicine. 32 (12), pp. 1339-1350.

The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology
Jones, C.L., Vasquez-Vivar, J., Kalyanaraman, B., Griscavage-Ennis, J.M., Gross, S.S. and Smith, C.L. 2002. The redox status of bound pterin cofactor determines whether eNOS produces NO or superoxide anion: [3H] - BH4 binding studies provide insights into vascular pathophysiology. in: Milstien, S., Kapatos, G., Levine, R.A. and Shane, B. (ed.) Chemistry and biology of pteridines and folates: proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, M.D. Boston, USA Kluwer Academic Publishers. pp. 271-276

Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding
Weissman, B.A., Jones, C.L., Liu, Q., Gross, S.S. and Smith, C.L. 2002. Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca2+-dependent [125I]Calmodulin binding. European Journal of Pharmacology. 435 (1), pp. 9-18.

Uremic concentrations of guanidino compounds inhibit neutrophil superoxide production
Hirayama, A., Noronha-Dutra, A., Gordge, M.P., Neild, G. and Hothersall, J. 2001. Uremic concentrations of guanidino compounds inhibit neutrophil superoxide production. Kidney International. 59 (suppl. 78), pp. 89-92.

An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase
Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M.E., Martasek, P., Roman, L.J., Masters, B.S.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., Gross, S.S. and Smith, C.L. 1997. An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. Journal of Biological Chemistry. 272 (47), pp. 29769-29777.

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