Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects. World Congress on Inflammation. London 08 - 12 Jul 2017
| Title | Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects |
|---|---|
| Authors | Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. |
| Type | Conference poster |
| Abstract | Inflammation and oxidative stress are both central contributors to a variety of neurodegenerative diseases (Bagyinszky et al., 2017; Leszek et al., 2016). Microglia are the resident macrophage-like immune cells in the brain and spinal cord, providing the first line of immunological defence. However, in disease, these cells become chronically activated, contributing to extensive neuronal damage (Rice et al., 2015). Dampening this activation may provide neurons critical protection against chronic inflammatory and oxidative damage. The aim of this study was to determine lipopolysaccharide (LPS)-induced inflammation and reactive oxygen species (ROS) release could be inhibited through the activation of the receptor Fpr2, known to play an important role in peripheral inflammatory resolution (de Oliveira et al., 2017). Immortalised murine microglia (BV2 cells) were stimulated with LPS (50ng/ml) for 1h prior to treatment with one of two Fpr2 ligands, Cpd43 or Quin-C1 (both 100nM). Cytokine (TNFα and IL-10) and nitric oxide (NO) production was detected at 24 and 48h. Following previous data investigating Fpr2 signaling (Cooray et al., 2013), FR180204 (10μM) or SB203580 (2μM), ERK1/2 and p38 MAP kinase blockers respectively, was added 10 minutes prior to either Fpr2 agonist. NO detection a 24h was then repeated. ROS were detected over time with carboxy-H2DCFDA. LPS was administered for 30 minutes prior to Cpd43 or Quin-C1, with ROS production recorded every 5 minutes for up to 1h. The protein expression of Annexin A1 – an endogenous ligand of Fpr2 with anti-inflammatory effects (Ries et al., 2016) – following Cpd43 or Quin-C1 treatment for 24h was determined by Western blot. Treatment with both Cpd43 and Quin-C1 significantly suppressed LPS-induced production of TNFα and NO at 24 and 48h. The suppression of NO was then blocked through the addition of SB203580. FR180204 had no effect. The anti-inflammatory effects may due to increased expression of AnxA1, which was detected at 24h. Further, both agonists enhanced production of IL-10 48h-post LPS exposure. Strikingly, both Cpd43 and Quin-C1 completely abolished LPS-induced ROS, with levels similar to untreated. Combined, these data highlight Fpr2 as novel therapeutic target to tackle inflammation and oxidative stress in neurodegenerative disease, through a synergistic pharmacological function. References Bagyinszky et al. (2017). J Neurol Sci 376: 242-254. Cooray et al. (2013). Proc Natl Acad Sci U S A 110: 18232-7. de Oliveira et al. (2017). Eur J Pharmacol 805: 46-50. Leszek et al. (2016). CNS Neurol Disord Drug Targets 15: 329-36. Rice et al. (2015). J Neurosci 35: 9977-9989. Ries et al. (2016). J Neuroinflammation 13: 1-15. |
| Keywords | Inflammation, anti-oxidative , annexin 1 |
| Year | 2017 |
| Conference | World Congress on Inflammation |
| Journal citation | (PP182) |
| Funder | Faculty of Science and Technology, University of Westminster |
| Web address (URL) of conference proceedings | http://depo.frame.com.tr/public_ftp/13.WCI-London2017.pdf |
| Web address (URL) | http://depo.frame.com.tr/public_ftp/13.WCI-London2017.pdf |
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The effect of silymarin on chondrocytes
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Reversal of β-amyloid induced microglial activation by an agonist of Fpr2
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Fpr2: a novel drug target to tackle oxidative stress and inflammation in Alzheimer’s disease
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Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation
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Getting, S.J., Can, V.C., Locke, I.C. and Grieco, P 2017. The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha. World Congress on Inflammation. London 08 - 12 Jul 2017
The formyl peptide receptor 2 (Fpr2) agonist, Compound 43 (Cpd43), attenuates and promotes the release of pro-inflammatory, and anti-inflammatory cytokines, respectively
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The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation
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Acute hypoxia reduces plasma myostatin independent of hypoxic dose
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Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.
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Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells. Society for Reproduction and Fertility Conference. EICC2, Edinburgh 1-2 September 2014
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Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion
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The central role of myostatin in skeletal muscle and whole body homeostasis
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Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system
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The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes
Can, V.C., Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2012. The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes. British Phamacological Society Winter Meeting 2012. London, UK 18th-20th December
Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2012. Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. British Journal of Pharmacology. 167 (1), pp. 67-79. https://doi.org/10.1111/j.1476-5381.2012.01968.x
The Melanocortin receptor system as an anti-inflammatory therapeutic target for stroke
Holloway, P.M., Getting, S.J. and Gavins, F.N.E. 2011. The Melanocortin receptor system as an anti-inflammatory therapeutic target for stroke. pA2 online, E-journal of the British Pharmacological Society.
Investigating the role of melanocortin receptor subtypes in mediating anti-inflammatory protection following cerebral ischemia reperfusion injury
Holloway, P.M., Getting, S.J. and Gavins, F.N.E. 2011. Investigating the role of melanocortin receptor subtypes in mediating anti-inflammatory protection following cerebral ischemia reperfusion injury. pA2 online, E-journal of the British Pharmacological Society.
Targeting the melanocortin receptor system for anti-stroke therapy
Holloway, P.M., Smith, H.K., Renshaw, D., Flower, R.J., Getting, S.J. and Gavins, F.N.E. 2011. Targeting the melanocortin receptor system for anti-stroke therapy. Trends in Pharmacological Sciences. 32 (2), pp. 90-98. https://doi.org/10.1016/j.tips.2010.11.010
REV5901 induces calcium dependant chondroprotective effects post in vitro mechanical loading
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α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes
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MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2011. MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes. Physiological Society Meeting 23. University of Oxford
Total pituitary hormone content in wild type and MC3 null male and female mice
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Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice
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Yazid, S., Leoni, G., Getting, S.J., Cooper, D., Solito, E., Perretti, M. and Flower, R.J. 2010. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via Annexin-A1 mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (9), pp. 1718-1724. https://doi.org/10.1161/ATVBAHA.110.209536
The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature
Leoni, G., Voisin, M.B., Carlson, K., Getting, S.J., Nourshargh, S. and Perretti, M. 2010. The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. British Journal of Pharmacology. 160 (1), pp. 171-180. https://doi.org/10.1111/j.1476-5381.2010.00688.x
Saliva: physiology and diagnostic potential in health and disease
Farnaud, S., Kosti, O., Getting, S.J. and Renshaw, D. 2010. Saliva: physiology and diagnostic potential in health and disease. ScientificWorldJournal. 10, pp. 434-456. https://doi.org/10.1100/tsw.2010.38
Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production. Society for Endocrinology BES 2010. Manchester 15th - 18th March 2010
A13/BACII, a novel bovine chondrocytic cell line with differentiation potential
Qusous, A., Kaneva, M., Getting, S.J. and Kerrigan, M.J.P. 2010. A13/BACII, a novel bovine chondrocytic cell line with differentiation potential. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan
Cartilage and macrophages: evidence for a paracrine loop. Poster no. 278
Parker, E., Qusous, A., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Cartilage and macrophages: evidence for a paracrine loop. Poster no. 278. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan
Tamoxifen: chondroprotective effects post-mechanical trauma
Parker, E., Peetroons, C., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Tamoxifen: chondroprotective effects post-mechanical trauma. Physiological Society Meeting 21. University of Durham
REV5901: chondroprotective effects post mechanical trauma
Parker, E., Noureen, S., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. REV5901: chondroprotective effects post mechanical trauma. Physiological Society Meeting 19. University of Manchester
The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2010. The effects of REV5901 on chondrocyte viability following mechanical trauma. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley.
Diurnal inflammatory cytokine changes post-exercise. Poster no. 319
Parker, E., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Diurnal inflammatory cytokine changes post-exercise. Poster no. 319. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan
Knee forces and inflammation: the effects of foot strike patterns and footwear
Parker, E., Domah, S., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Knee forces and inflammation: the effects of foot strike patterns and footwear. Physiological Society Meeting 19. University of Manchester
Chondroitin and glucosamine supplementation results in increased chondrocyte viability post mechanical trauma in vitro
Parker, E., Begum, N., Wunderlich, C., Ravichandran, N., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Chondroitin and glucosamine supplementation results in increased chondrocyte viability post mechanical trauma in vitro. Physiological Society Meeting 19. University of Manchester
REV5901: the protective effect on bovine articular chondrocytes following single impact trauma
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: the protective effect on bovine articular chondrocytes following single impact trauma. Physiological Society Meeting 19. University of Manchester
REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma. Physiological Society Meeting 21. University of Durham
α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes
Kaneva, M., Locke, I.C., Kerrigan, M.J.P. and Getting, S.J. 2010. α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes. British Pharmacological Society Winter Meeting 2010. London, UK 14th-16th December 2010
Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley. pp. PO136
The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. Physiology 2010. University of Manchester 30 June - 2 July 2010
Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3). Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010
Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis
Patel, H.B., Bombardieri, M., Sampaio, A.L.F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S.J., Pitzalis, C. and Perretti, M. 2010. Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis. FASEB Journal. 24 (12), pp. 4835-4843. https://doi.org/10.1096/fj.10-167759
Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. British Orthopaedic Research Society (BORS) Annual Meeting. Newcastle 22nd - 23rd June 2009
The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2009. The effects of REV5901 on chondrocyte viability following mechanical trauma. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4), p. P0149. https://doi.org/http://www.pa2online.org/abstracts/Vol7Issue4abst127P.pdf
Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society.
Molecular characterization of the melanocortin 3 receptor in the testes of mice
Horanin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F. 2009. Molecular characterization of the melanocortin 3 receptor in the testes of mice. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol7Issue4abst089P.pdf
Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414. https://doi.org/10.1100/tsw.2009.163
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Murray, J.F., Grieco, P., Getting, S.J. and Perretti, M. 2008. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB Journal. 22 (12), pp. 4228-4238. https://doi.org/10.1096/fj.08-113886
A role for MC3R in modulating lung inflammation
Getting, S.J., Riffo-Vasquez, Y., Pitchford, S., Kaneva, M., Grieco, P., Page, C.P., Perretti, M. and Spina, D. 2008. A role for MC3R in modulating lung inflammation. Pulmonary Pharmacology and Therapeutics. 21 (6), pp. 866-873. https://doi.org/10.1016/j.pupt.2008.09.004
Melanocortin 3 receptor in the testes of mice
Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. Society for Reproduction and Fertility. Edinburgh 29 Jun - 01 Jul 2008 pp. Abstract P80
Melanocortin 3 receptor in the testes of mice
Wotherspoon, G., Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. P008.
Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro
Stenbeck, G., Joseph, J., Getting, S.J. and Smith, C.L. 2008. Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C041.
The role of the actin cytoskeleton in chondrocyte protection following single impact
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2008. The role of the actin cytoskeleton in chondrocyte protection following single impact. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol6Issue4abst148P.pdf
Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor. Journal of Vascular Research. 45 (Suppl2).
Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation. William Harvey Day. St. Barts Hospital, London 14th October 2008
A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells
Getting, S.J., Kaneva, M. and Kerrigan, M.J.P. 2008. A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C020.
Melanocortins
Getting, S.J. 2008. Melanocortins. in: Offermanns, S. and Rosenthal, W. (ed.) Encyclopedia of molecular pharmacology. 2nd edition Berlin Springer. pp. 752-757
The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling
Ali, N., Getting, S.J. and Kerrigan, M.J.P. 2008. The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol6Issue4abst092P.pdf
Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S. and Whitton, P.S. 2008. Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease. Journal of Neuroinflammation. 5 19. https://doi.org/10.1186/1742-2094-5-19
Endogenous MC3R and inhibition of inflammatory arthritis. PC112
Patel, H.B., Sampaio, A.L.F., Getting, S.J., Gray, M. and Perretti, M. 2007. Endogenous MC3R and inhibition of inflammatory arthritis. PC112. Life Sciences. Glasgow 8th - 12th July 2007
Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106
Leoni, G., Getting, S.J., Gavins, F.N.E. and Perretti, M. 2007. Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106. Life Sciences. Glasgow 8th - 12th July 2007
Glucocorticoid and melanocortins: special issue
Getting, S.J. 2007. Glucocorticoid and melanocortins: special issue. ScientificWorldJournal. 7, pp. 1463-1464. https://doi.org/10.1100/tsw.2007.93
The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
Abuirmeileh, A., Lever, R., Kingsbury, A.E., Lees, A.J., Locke, I.C., Knight, R.A., Chowdrey, H.S., Biggs, C.S. and Whitton, P.S. 2007. The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience. 26 (2), pp. 417-423. https://doi.org/10.1111/j.1460-9568.2007.05653.x
Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
Abuirmeileh, A., Harkavyi, A., Lever, R., Biggs, C.S. and Whitton, P.S. 2007. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. Journal of Neuroinflammation. 4 19. https://doi.org/10.1186/1742-2094-4-19
[D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse)
Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N.E., Grieco, P. and Perretti, M. 2006. [D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse). Molecular Pharmacology. 70 (6), pp. 1850-1855. https://doi.org/10.1124/mol.106.028878
Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart
Gavins, F.N.E., Leoni, G. and Getting, S.J. 2006. Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart. ScientificWorldJournal. 6, pp. 1008-1023. https://doi.org/10.1100/tsw.2006.196
Targeting melanocortin receptors as potential novel therapeutics
Getting, S.J. 2006. Targeting melanocortin receptors as potential novel therapeutics. Pharmacology & Therapeutics. 111 (1), pp. 1-15. https://doi.org/10.1016/j.pharmthera.2005.06.022
Melanocortin receptor signaling in RAW264.7 macrophage cell line
Lam, C.W., Perretti, M. and Getting, S.J. 2006. Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides. 27 (2), pp. 404-412. https://doi.org/10.1016/j.peptides.2005.01.031
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
Getting, S.J., Di Filippo, C., D'Amico, M. and Perretti, M. 2006. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. European Journal of Pharmacology. 532 (1-2), pp. 138-144. https://doi.org/10.1016/j.ejphar.2005.12.023
Mode of glucocorticoid actions in airway disease
Ito, K., Getting, S.J. and Charron, C.E. 2006. Mode of glucocorticoid actions in airway disease. ScientificWorldJournal. 28 (6), pp. 1750-1769. https://doi.org/10.1100/tsw.2006.274
Melanocortin 3 receptors control crystal-induced inflammation
Getting, S.J., Lam, C.W., Chen, A.S., Grieco, P. and Perretti, M. 2006. Melanocortin 3 receptors control crystal-induced inflammation. FASEB Journal. 20 (13), pp. 2234-2241.
In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation
Lam, C.W., Getting, S.J. and Perretti, M. 2005. In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. Journal of Immunology. 174 (4), pp. 2297-2304.
Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat
Biggs, C.S., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat. 18th National Meeting of the British Neuroscience Association. Brighton, UK 03-06 Apr 2005
Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model
Biggs, C.S., Abuirmeileh, A., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society. 3 (4).
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M. and Perretti, M. 2004. MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Journal of Leukocyte Biology. 76 (4), pp. 845-853. https://doi.org/10.1189/jlb.0306175
Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo
Cao, T.V., La, M., Getting, S.J. and Day, A.J. 2004. Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation. 11 (7), pp. 615-624. https://doi.org/10.1080/10739680490503438
Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis
Getting, S.J., Di Filippo, C., Lam, C.W., Rossi, F. and D'Amico, M. 2004. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. Journal of Pharmacology and Experimental Therapeutics. 310 (1), pp. 90-97. https://doi.org/10.1124/jpet.104.065573
Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
Yang, Y.H., Morand, E.F., Getting, S.J. and Paul-Clark, M. 2004. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis & Rheumatism. 50 (3), pp. 976-984. https://doi.org/10.1002/art.20201
The annexin 1-/- mouse: phenotypic studies
Wells, D., Wells, K., Liu, K., Hannon, R., Croxtall, J.D., Damazo, A.S., Oliani, S.M., Getting, S.J., Parente, L., Paul-Clark, M., Yona, S., Gavins, F.N.E., Martin, J., Christian, H.C., Cover, P.O., John, C.D., Solito, E., Morris, J.F., Perretti, M., Buckingham, J.C. and Flower, R.J. 2004. The annexin 1-/- mouse: phenotypic studies. Annexins. 1 (2), pp. 109-120.
Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages
Lam, C.W., Getting, S.J. and Perretti, M. 2004. Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages. pA2 Online. Winter 2004 Meeting: Proceedings of the British Pharmacological Society.
Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy
Lam, C.W. and Getting, S.J. 2004. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Current Drug Targets. Inflammation & Allergy. 3 (3), pp. 311-315.
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
Getting, S.J., Schiöth, H.B. and Perretti, M. 2003. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. 306 (2), pp. 631-637. https://doi.org/10.1124/jpet.103.051623
Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor
Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N.E., Flower, R.J., Schiöth, H.B. and Perretti, M. 2003. Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. Journal of Immunology. 170 (6), pp. 3323-3330.
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
Hannon, R., Croxtall, J.D., Getting, S.J., Roviezzo, F., Yona, S., Paul-Clark, M., Gavins, F.N.E., Perretti, M., Morris, J.F., Buckingham, J.C. and Flower, R.J. 2003. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB Journal. 17 (2), pp. 253-255. https://doi.org/10.1096/fj.02-0239fje
Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. Methods in Molecular Biology. 225, pp. 139-146. https://doi.org/10.1385/1-59259-374-7:139
Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo. in: Winyard, P.G. and Willoughby, D.A. (ed.) Inflammation Protocols Totowa, NJ Humana Press. pp. 139-146
The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner
Getting, S.J., Mahoney, D.J., Cao, T.V., Rugg, M.S., Fries, E., Milner, C.M., Perretti, M. and Day, A.J. 2002. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. Journal of Biological Chemistry. 277 (52), pp. 51068-51076. https://doi.org/10.1074/jbc.M205121200
The annexin-1 knockout mouse: what it tells us about the inflammatory response
Roviezzo, F., Getting, S.J., Paul-Clark, M., Yona, S., Gavins, F.N.E., Perretti, M., Hannon, R., Croxtall, J.D., Buckingham, J.C. and Flower, R.J. 2002. The annexin-1 knockout mouse: what it tells us about the inflammatory response. Journal of Physiology and Pharmacology. 53 (4, part 1), pp. 541 -553.
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Perretti, M., Chiang, N., La, M., Fierro, I.M., Marullo, S., Getting, S.J., Solito, E. and Serhan, C.N. 2002. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nature Medicine. 8 (11), pp. 1296-1302. https://doi.org/10.1038/nm786
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
Getting, S.J., Christian, H.C., Flower, R.J. and Perretti, M. 2002. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis & Rheumatism. 46 (10), pp. 2765-2775. https://doi.org/10.1002/art.10526
Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy
Getting, S.J. 2002. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends in Pharmacological Sciences. 23 (10), pp. 447-449. https://doi.org/10.1016/S0165-6147(02)02103-X
A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones
Malcangio, M., Getting, S.J., Grist, J., Cunningham, J.R., Bradbury, E.J., Issa, P.C., Lever, I.J., Pezet, S. and Perretti, M. 2002. A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB Journal. 16 (7), pp. 730-732. https://doi.org/10.1096/fj.01-0971fje.
Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma
Carollo, M., Getting, S.J., Delaney, S., Christie, M.I. and Perretti, M. 2002. Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma. Inflammation Research. 51 (2), pp. 110-111. https://doi.org/10.1007/BF02684013
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti, M., Getting, S.J., Solito, E., Murphy, P.M. and Gao, J.L. 2001. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. American Journal of Pathology. 158 (6), pp. 1969-1973.
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Mabley, J.G., Jagtap, P., Perretti, M., Getting, S.J., Salzman, A.L., Virag, L., Szabo, E., Soriano, F.G., Liaudet, L., Hasko, G., Marton, A., Southan, G.J., Abdelkarim, G.E. and Szabo, C. 2001. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation Research. 50 (11), pp. 561-569. https://doi.org/10.1007/PL00000234
Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics
Getting, S.J. and Perretti, M. 2001. Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs. 2 (8), pp. 1064-1069.
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
Getting, S.J., Allcock, G.H., Flower, R.J. and Perretti, M. 2001. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. Journal of Leukocyte Biology. 69 (1), pp. 98-104.
MC3-R as a novel target for anti-inflammatory therapy
Getting, S.J. and Perretti, M. 2000. MC3-R as a novel target for anti-inflammatory therapy. Drug News & Perspectives. 13 (1), pp. 19-27.
POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
Getting, S.J., Gibbs, L., Clark, A.J.L., Flower, R.J. and Perretti, M. 1999. POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology. 162 (12), pp. 7446-7453.
Compounds for use in the treatment of inflammation
Flower, R.J., Getting, S.J. and Perretti, M. 1998. Compounds for use in the treatment of inflammation.
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects
Szabo, C., Lim, L.H.K., Cuzzocrea, S., Getting, S.J., Zingarelli, B., Flower, R.J., Salzman, A.L. and Perretti, M. 1997. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of experimental medicine. 186 (7), pp. 1041-1049. https://doi.org/10.1084/jem.186.7.1041
Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
Getting, S.J., Flower, R.J., Parente, L., de Medicis, R., Lussier, A., Woliztky, B.A., Martins, M.A. and Perretti, M. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics. 283 (1), pp. 123-130.
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1
Getting, S.J., Flower, R.J. and Perretti, M. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology. 120 (6), pp. 1075-1082. https://doi.org/10.1038/sj.bjp.0701029
Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes
Tailor, A., Das, A.M., Getting, S.J., Flower, R.J. and Perretti, M. 1997. Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications. 231 (3), pp. 675-678. https://doi.org/10.1006/bbrc.1997.6168
Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199. https://doi.org/10.1016/0006-8993(96)00127-8
Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104. https://doi.org/10.1016/0304-3940(95)12088-L
Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo
Segieth-Beever, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo. Wiley. https://doi.org/10.1111/j.1476-5381.1995.tb17200.x
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