Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat

Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
Edward S. Wickstead, Bradley T. Elliott, Sarah Pokorny, Christopher Biggs, Stephen J. Getting and Simon McArthur 2023. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. International Journal of Molecular Sciences. 24 (21). https://doi.org/10.3390/ijms242115996

Regulation of TNF-Induced Osteoclast Differentiation.
Yao, Zhenqiang, Getting, Stephen J and Locke, Ian C 2021. Regulation of TNF-Induced Osteoclast Differentiation. Cells. 11 (1) e132. https://doi.org/cells11010132

Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3
Getting, S.J., McArthur, S., Wickstead, E. and Biggs, C.S. 2020. Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. 2020 2139192. https://doi.org/10.1155/2020/2139192

Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2018. Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure. Alzheimer's Research UK Conference. London 20 - 21 Mar 2018

Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering
Bagdadi, A., Safari, M., Dubey, P., Basnett, P., Sofokleous P., Humphrey E, Locke, I.C., Edirisinghe M., Terracciano C., Boccaccini, A.R., Knowles, J.C., Harding, S. and Roy, I. 2018. Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 12 (1), pp. E495-E512. https://doi.org/10.1002/term.2318

The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta.
Can, V.C., Locke, I.C., Grieco, P. and Getting, S.J. 2017. The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta. Pharmacology 2017. London, U.K. 11 - 13 Dec 2017 British Pharmacological Society.

The effect of silymarin on chondrocytes
Can, V.C., Abouelnour, A., Locke, I.C., Bligh, S.W.A. and Getting, S.J. 2017. The effect of silymarin on chondrocytes. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Elsevier. https://doi.org/10.1016/j.bcp.2017.06.036

Reversal of β-amyloid induced microglial activation by an agonist of Fpr2
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Reversal of β-amyloid induced microglial activation by an agonist of Fpr2. British Pharmacological Society: Pharmacology 2017. London 11 - 13 Dec 2017

Chondroprotection by urocortin involves blockade of a mechanosensitive piezo1 ion channel: novel, exploitable pathways for the treatment and prevention of osteoarthritis?
Lawrence, K.M., Jones, R.C., Jackson, T.R., Baylie, R.L., Abbot, B., Bruhn-Olszewska, B, Board, T.N., Locke, I.C., Richardson, S.M and Townsend, P.A. 2017. Chondroprotection by urocortin involves blockade of a mechanosensitive piezo1 ion channel: novel, exploitable pathways for the treatment and prevention of osteoarthritis? OARSI 2017 World Congress on Osteoarthritis. Las Vegas, USA. 17 - 20 Apr 2017 Elsevier. https://doi.org/10.1016/j.joca.2017.02.124

Urocortin protects chondrocytes from acute trauma in articular cartilage
Jones, R.C., Jackson, TR, Locke, I.C., Board, T.N., Richardson, S.M., Townsend, P.A. and Lawrence, K.M. 2017. Urocortin protects chondrocytes from acute trauma in articular cartilage. OARSI 2017 World Congress on Osteoarthritis. Las Vegas, USA 27 - 30 Apr 2017 Elsevier. https://doi.org/10.1016/j.joca.2017.02.291

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1
Lawrence, K.M., Jones, R.C., Jackson, T.R., Baylie, R.L., Abbott, B., Bruhn-Olszewska, B., Board, T.N., Locke, I.C., Richardson, S.M. and Townsend, P.A. 2017. Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. Scientific Reports. 7 (1), p. 5147 5147. https://doi.org/10.1038/s41598-017-04367-4

Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation. BNA Festival of Neuroscience. Birmingham 10 - 13 Apr 2017 Sage. https://doi.org/10.1177/2398212817705279

The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha
Getting, S.J., Can, V.C., Locke, I.C. and Grieco, P 2017. The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha. World Congress on Inflammation. London 08 - 12 Jul 2017

Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects. World Congress on Inflammation. London 08 - 12 Jul 2017

Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration
Rai, R., Roether, J.A., Knowles, J.C., Mordan, N., Salih, V., Locke, I.C., Gordge, M.P., McCormick, A., Mohn, D., Stark, W.J., Keshavarz, T., Boccaccini, A.R. and Roy, I. 2017. Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials . 66 (7), pp. 326-335. https://doi.org/10.1080/00914037.2016.1217530

Novel P(3HB) Composite Films Containing Bioactive Glass Nanoparticles for Wound Healing Applications
Francis, L., Meng, D., Locke, I.C., Knowles, J.C., Mordan, N., Salih, V., Boccaccini, A.R. and Roy, I. 2016. Novel P(3HB) Composite Films Containing Bioactive Glass Nanoparticles for Wound Healing Applications. Polymer International. 65 (6), pp. 661-674. https://doi.org/10.1002/pi.5108

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation
Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015 . Cardiff, UK. 08 Jul 2015

Urocortin – From Parkinson’s disease to the skeleton
Lawrence, K.M., Jackson, T.R, Jamieson, D., Stevens, A., Owens, G., Sayan, B.S, Locke, I.C. and Townsend, P.A. 2015. Urocortin – From Parkinson’s disease to the skeleton. International Journal of Biochemistry & Cell Biology. 30, pp. 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation
Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015. Cardiff Jun 2015

Poly(3-hydroxybutyrate)-ethyl cellulose based bio-composites with novel characteristics for infection free wound healing application
Iqbal, H.M.N., Kyazze, G., Locke, I.C., Tron, T. and Keshavarz, T. 2015. Poly(3-hydroxybutyrate)-ethyl cellulose based bio-composites with novel characteristics for infection free wound healing application. International Journal of Biological Macromolecules. 81, pp. 552-559. https://doi.org/10.1016/j.ijbiomac.2015.08.040

Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity
Iqbal, H.M.N., Kyazze, G., Locke, I.C., Tron, T. and Keshavarz, T. 2015. Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity. eXPRESS Polymer Letters. 9 (9), p. 764–772. https://doi.org/10.3144/expresspolymlett.2015.72

Development of bio-composites with novel characteristics: Evaluation of phenol-induced antibacterial, biocompatible and biodegradable behaviours
Iqbal, H.M.N., Kyazze, G., Locke, I.C., Tron, T. and Keshavarz, T. 2015. Development of bio-composites with novel characteristics: Evaluation of phenol-induced antibacterial, biocompatible and biodegradable behaviours. Carbohydrate Polymers. 131, pp. 197-207. https://doi.org/10.1016/j.carbpol.2015.05.046

In-situ development of self-defensive antibacterial biomaterials: phenol-g-keratin-EC based bio-composites with characteristics for biomedical applications
Iqbal, H.M.N., Kyazze, G., Locke, I.C., Tron, T. and Keshavarz, T. 2015. In-situ development of self-defensive antibacterial biomaterials: phenol-g-keratin-EC based bio-composites with characteristics for biomedical applications. Green Chemistry. 17 (7), pp. 3858-3869. https://doi.org/10.1039/C5GC00715A

Anatomy, embryology, and cell families
Locke, I.C. and Murray, J.F. 2014. Anatomy, embryology, and cell families. in: Orchard, G. and Nation, B. (ed.) Cell Structure & Function Oxford, UK Oxford University Press. pp. 82-110

The melanocortin receptor antagonist SHU9119 inhibits the anti-inflammatory/pro-resolving properties of a-MSH and D[TRP8]-y-MSH in lipopolysaccharide stimulated chondrocytes
Can, V.C., Locke, I.C. and Getting, S.J. 2014. The melanocortin receptor antagonist SHU9119 inhibits the anti-inflammatory/pro-resolving properties of a-MSH and D[TRP8]-y-MSH in lipopolysaccharide stimulated chondrocytes. Pharmacology 2014. Queen Elizabeth Centre II, London, UK 16 Dec 2014 British Pharmacological Society.

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury
Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2014. Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochemical Pharmacology. 92 (2), pp. 336-347. https://doi.org/10.1016/j.bcp.2014.08.019

Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion
Ashioti, M., Getting, S.J., Locke, I.C. and Milton, N.G.N. 2013. Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion. British Neuroscience Association 22nd Biennial Meeting. London 7th-10th April 2013

Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?
Intekhab Alam, N.Y., White, O.B., Getting, S.J., Petsa, A., Knight, R.A., Townsend, P.A., Lawrence, K.M. and Locke, I.C. 2013. Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis? Cell Death and Disease. 4, p. e717. https://doi.org/10.1038/cddis.2013.231

Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C. and Roy, I. 2013. Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents. Bioinspired, Biomimetic and Nanobiomaterials. 2 (3), pp. 141-153. https://doi.org/10.1680/bbn.13.00009

Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications
Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.L., Locke, I.C., Keshavarz, T. and Roy, I. 2013. Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive and Functional Polymers. 73 (10), pp. 1340-1348. https://doi.org/10.1016/j.reactfunctpolym.2013.03.019

Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel
Combs, C., Fuller, K., Kumar, H., Albert, A.P., Pirianov, G., McCormick, J., Locke, I.C., Chambers, T.J. and Lawrence, K.M. 2012. Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel. Journal of Endocrinology. 212 (2), pp. 187-197. https://doi.org/10.1530/JOE-11-0254

The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes
Can, V.C., Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2012. The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes. British Phamacological Society Winter Meeting 2012. London, UK 18th-20th December

Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2012. Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. British Journal of Pharmacology. 167 (1), pp. 67-79. https://doi.org/10.1111/j.1476-5381.2012.01968.x

Chondrocyte CRF receptor expression and Urocortin I mediated chondroprotection
White, O.B., Intekhab-Alam, N.Y., Chowdrey, H.S., Knight, R.A., Locke, I.C. and Intekhab Alam, N.Y. 2011. Chondrocyte CRF receptor expression and Urocortin I mediated chondroprotection. Rheumatology 2011. Brighton, UK 12th-14th April 2011

α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2011. α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes. 10th World Congress on Inflammation. Paris, France 25–29 June 2011

MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2011. MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes. Physiological Society Meeting 23. University of Oxford

The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering
Rai, R., Boccaccini, A.R., Knowles, J.C., Mordon, N., Salih, V., Locke, I.C., Moshrefi-Torbati, M., Keshavarz, T. and Roy, I. 2011. The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering. Journal of Applied Polymer Science. 122 (6), pp. 3606-3617. https://doi.org/10.1002/app.34772

Mechanisms of Urocortin family peptide mediated chondroprotection
White, O.B., Intekhab Alam, N.Y., Chowdrey, H.S., Knight, R.A. and Locke, I.C. 2010. Mechanisms of Urocortin family peptide mediated chondroprotection. OARSI 2010 World Congress on Osteoarthritis. Brussels, Belgium September 23-26, 2010 https://doi.org/10.1016/S1063-4584(10)60288-9

The effect of indentor shape on the creep curves of collagen gel
Locke, I.C., White, O.B., Trwoga, P. and Afoke, A. 2010. The effect of indentor shape on the creep curves of collagen gel. OARSI 2010 World Congress on Osteoarthritis. Brussels, Belgium September 23-26, 2010 https://doi.org/10.1016/S1063-4584(10)60511-0

α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes
Kaneva, M., Locke, I.C., Kerrigan, M.J.P. and Getting, S.J. 2010. α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes. British Pharmacological Society Winter Meeting 2010. London, UK 14th-16th December 2010

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley. pp. PO136

The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. Physiology 2010. University of Manchester 30 June - 2 July 2010

Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing
Rai, R., Boccaccini, A.R., Knowles, J.C., Locke, I.C., Gordge, M.P., McCormick, A., Salih, V., Mordon, N., Keshavarz, T. and Roy, I. 2010. Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing. 5th international conference on times of polymers (TOP) and composites. Ischia, Italy 20–23 June 2010 https://doi.org/10.1063/1.3455552

The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres
Francis, L., Meng, D., Locke, I.C., Mordon, N., Salih, V., Knowles, J.C., Boccaccini, A.R. and Roy, I. 2010. The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres. Advanced Engineering Materials. 12 (7), pp. B260-B268. https://doi.org/10.1002/adem.201080020

Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. British Orthopaedic Research Society (BORS) Annual Meeting. Newcastle 22nd - 23rd June 2009

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society.

Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414. https://doi.org/10.1100/tsw.2009.163

Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury
Knight, R.A., Chen-Scarabelli, C., Yuan, Z., McCauley, R.B., Di Rezzec, J., Scarabelli, G.M., Townsend, P.A., Latchman, D., Saravolatz, L., Faggian, G., Mazzucco, A., Chowdrey, H.S., Stephanou, A. and Scarabelli, T.M. 2008. Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury. F E B S Letters. 582 (6), pp. 984-990. https://doi.org/10.1016/j.febslet.2008.02.035

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S. and Whitton, P.S. 2008. Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease. Journal of Neuroinflammation. 5 19. https://doi.org/10.1186/1742-2094-5-19

Artificial Odor Discrimination System using electronic nose and neural networks for the identification of urinary tract infection
Kodogiannis, V., Lygouras, J.N., Tarczynski, A. and Chowdrey, H.S. 2008. Artificial Odor Discrimination System using electronic nose and neural networks for the identification of urinary tract infection. IEEE Transactions on Information Technology in Biomedicine. 12 (6), pp. 707-713. https://doi.org/10.1109/TITB.2008.917928

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery
Shah, C.M., Bell, S.E., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2007. Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery. Nitric Oxide. 16 (1), pp. 135-142. https://doi.org/10.1016/j.niox.2006.08.001

The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
Abuirmeileh, A., Lever, R., Kingsbury, A.E., Lees, A.J., Locke, I.C., Knight, R.A., Chowdrey, H.S., Biggs, C.S. and Whitton, P.S. 2007. The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience. 26 (2), pp. 417-423. https://doi.org/10.1111/j.1460-9568.2007.05653.x

Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
Abuirmeileh, A., Harkavyi, A., Lever, R., Biggs, C.S. and Whitton, P.S. 2007. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. Journal of Neuroinflammation. 4 19. https://doi.org/10.1186/1742-2094-4-19

Biological activity of industrial wood and bark waste from Pinus nigra
Curras Lino, M., Radman, R., Bertaud, F., Nisula, L., Lenon, G., Holbom, B., Locke, I.C., Thompson, S. and Keshavarz, T. 2006. Biological activity of industrial wood and bark waste from Pinus nigra. in: Actual problems of creation of new medicinal preparations of natural origin: the 10th international congress PHYTOPHARM 2006, St.-Petersburg, June 27-30, 2006: proceedings of congress St Petersburg, Russia PHYTOPHARM. pp. 401-403

Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells
Prashar, A., Locke, I.C. and Evans, C.S. 2006. Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells. Cell Proliferation. 39 (4), pp. 241-248. https://doi.org/10.1111/j.1365-2184.2006.00384.x

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes
Shah, C.M., Walters, S.E., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2005. Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes. Ireland-UK Platelet Conference 2005. Dublin, Ireland 04-06 Sep 2005

A neurofuzzy methodology for the diagnosis of wireless-capsule endoscopic images
Kodogiannis, V. and Chowdrey, H.S. 2005. A neurofuzzy methodology for the diagnosis of wireless-capsule endoscopic images. in: Duch, W., Kacprzyk, J., Oja, E. and Zadrozny, S. (ed.) Artificial Neural Networks: Biological Inspirations ICANN 2005: 15th International Conference Warsaw, Poland, September 11-15, 2005 Proceedings, Part I Berlin, Germany Springer.

Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model
Biggs, C.S., Abuirmeileh, A., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society. 3 (4).

Intracorporeal videoprobe (IVP)
Arena, A., Boulougoura, M., Chowdrey, H.S., Dario, P., Harendt, C., Irion, K.M., Kodogiannis, V., Lenaerts, B., Menciassi, A., Puers, R., Scherjon, C. and Turgis, D. 2005. Intracorporeal videoprobe (IVP). in: Bos, L., Laxminarayan, S. and Marsh, A.J. (ed.) Medical and Care Compunetics Amsterdam, Netherlands ; Oxford, UK IOS Press.

Cell surface thiol modification by GSNO: a mechanism of nitric oxide delivery?
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Cell surface thiol modification by GSNO: a mechanism of nitric oxide delivery? 5th UK Nitric Oxide Forum. Edinburgh, UK 12/2004

Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan. Nara, Japan 24-28 May 2004 https://doi.org/10.1016/j.niox.2004.07.004

Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2004. Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. Japan-UK Platelet Conference. Oxford, UK September 2004

Establishment and analysis of 3-D collagen cultures of C-20/A4 chondrocytes
Petsa, A., Chowdrey, H.S., Knight, R.A., Afoke, A. and Locke, I.C. 2004. Establishment and analysis of 3-D collagen cultures of C-20/A4 chondrocytes. OARSI 2004 World Congress on Osteoarthritis. Chicago USA 12/2004 https://doi.org/10.1016/j.joca.2004.09.004

Multi network classification scheme for computer-aided diagnosis in clinical endoscopy
Kodogiannis, V. and Chowdrey, H.S. 2004. Multi network classification scheme for computer-aided diagnosis in clinical endoscopy. in: MEDSIP 2004: Advances in Medical Signal and Information Processing International Conference, 5-8 September 2004, Malta IEEE . pp. 262-267

A CRH family peptide protects a human chondrocyte cell line against apoptosis
Intekhab-Alam, N.Y., Chowdrey, H.S., Knight, R.A., Locke, I.C. and Intekhab Alam, N.Y. 2004. A CRH family peptide protects a human chondrocyte cell line against apoptosis. OARSI 2004 World Congress on Osteoarthritis. Chicago USA 12/2004 https://doi.org/10.1016/j.joca.2004.09.004

Intelligent systems for computer-assisted clinical endoscopic image analysis
Boulougoura, M., Wadge, E., Kodogiannis, V. and Chowdrey, H.S. 2004. Intelligent systems for computer-assisted clinical endoscopic image analysis. in: Tilg, B. (ed.) Proceedings of the second IASTED international conference on biomedical engineering Anaheim, California, USA Acta Press.

Cytotoxicity of lavender oil and its major components to human skin cells
Prashar, A., Locke, I.C. and Evans, C.S. 2004. Cytotoxicity of lavender oil and its major components to human skin cells. Cell Proliferation. 37 (3), pp. 221-229. https://doi.org/10.1111/j.1365-2184.2004.00307.x

Functional characteristics of the streptococcal deoxyribonuclease 'streptodornase', a protein with DNase activity present in the medicament Varidase
Locke, I.C. and Carpenter, B.G. 2004. Functional characteristics of the streptococcal deoxyribonuclease 'streptodornase', a protein with DNase activity present in the medicament Varidase. Enzyme and Microbial Technology. 35 (1), pp. 67-73. https://doi.org/10.1016/j.enzmictec.2004.03.009

Rapid S-nitrosothiol metabolism by platelets and megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2003. Rapid S-nitrosothiol metabolism by platelets and megakaryocytes. Biochemical Society Transactions. 31 (6), pp. 1450-1452.

Role of protein disulphide isomerase in NO delivery from S-nitrosothiols into megakaryocytes
Shah, C.M., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2003. Role of protein disulphide isomerase in NO delivery from S-nitrosothiols into megakaryocytes. 4th UK Nitric Oxide Forum. University of Nottingham, UK December 2003

The behaviour of C-20/A4 chondrocytes in 3-D collagen gel cultures
Petsa, A., Afoke, A., Chowdrey, H.S., Knight, R.A., Harris, A. and Locke, I.C. 2003. The behaviour of C-20/A4 chondrocytes in 3-D collagen gel cultures. OARSI 2003 World Congress on Osteoarthritis. Berlin, Germany October 2003 https://doi.org/10.1016/S1063-4584(03)00192-4

Ion-dependency of the streptococcal deoxyribonuclease "streptodornase", an active constituent of the medicament Varidase
Locke, I.C. and Carpenter, B.G. 2002. Ion-dependency of the streptococcal deoxyribonuclease "streptodornase", an active constituent of the medicament Varidase. Enzyme and Microbial Technology. 31 (4), pp. 482-489. https://doi.org/10.1016/S0141-0229(02)00125-4

Effect of essential oils and their components on cell
Prashar, A., Veness, R., Locke, I.C. and Evans, C.S. 2002. Effect of essential oils and their components on cell. Future Trends in Phytochemistry. Gargnano, Italy

Electronic nose: clinical diagnosis based on soft computing methodologies
Kodogiannis, V., Chountas, P., Pavlou, A.K., Petrounias, I., Chowdrey, H.S. and Temponi, C. 2002. Electronic nose: clinical diagnosis based on soft computing methodologies. in: Proceedings of the IEEE International Symposium Intelligent Systems: Methodology, Models, Applications in Emerging Technologies IS2002, 10-12 Sept.2002, Varna, Bulgaria USA IEEE .

Electronic nose: clinical diagnosis based on soft computing methodologies
Kodogiannis, V., Chountas, P., Pavlou, A.K. and Chowdrey, H.S. 2001. Electronic nose: clinical diagnosis based on soft computing methodologies. in: 2002 First International IEEE Symposium "Intelligent Systems" proceedings: September 10-12, 2002, St. Constantine and Helena resort, Varna, Bulgaria USA IEEE . pp. 254-259

Varidase: the science behind the medicament
Rutter, P.M., Carpenter, B.G., Hill, S.S. and Locke, I.C. 2000. Varidase: the science behind the medicament. Journal of Wound Care. 9 (5), pp. 223-226.

A comparison of the characteristics of circulating anti-myeloperoxidase antibodies in vasculitis with those in non-vasculitic conditions
Locke, I.C., Leaker, B. and Cambridge, G. 1999. A comparison of the characteristics of circulating anti-myeloperoxidase antibodies in vasculitis with those in non-vasculitic conditions. Clinical and Experimental Immunology. 115 (2), pp. 369-376. https://doi.org/10.1046/j.1365-2249.1999.00809.x

A comparison of the variable region genes of two human monoclonal antibodies to myeloperoxidase
Locke, I.C., Rahman, M.A.A. and Cambridge, G. 1998. A comparison of the variable region genes of two human monoclonal antibodies to myeloperoxidase. British Society for Immunology 6th Annual Meeting. Harrogate, UK 12/1998

Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles
Liu, Y.Z., Lee, I.K., Locke, I.C., Dawson, S. and Latchman, D. 1998. Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles. Nucleic Acids Research. 26 (10), pp. 2464-2472. https://doi.org/10.1093/nar/26.10.2464

Purification of a streptococcal deoxyribonuclease by affinity chromatography based on a DNA-cellulose matrix
Locke, I.C., Cox, S.F. and Carpenter, B.G. 1997. Purification of a streptococcal deoxyribonuclease by affinity chromatography based on a DNA-cellulose matrix. Journal of Chromatography A. 788 (1-2), pp. 75-80. https://doi.org/10.1016/S0021-9673(97)00695-X

Autoantibodies to myeloperoxidase in systemic sclerosis
Locke, I.C., Worral, J.G., Leaker, B., Black, C.M. and Cambridge, G. 1997. Autoantibodies to myeloperoxidase in systemic sclerosis. Journal of Rheumatology. 24 (1), pp. 86-89.

Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199. https://doi.org/10.1016/0006-8993(96)00127-8

Characteristics of antibodies to myeloperoxidase in vasculitic and non-vasculitic conditions
Locke, I.C., Leaker, B. and Cambridge, G. 1996. Characteristics of antibodies to myeloperoxidase in vasculitic and non-vasculitic conditions. American College of Rheumatology 60th National Scientific Meeting. Orlando, USA 10/1996

Characteristics of anti-myeloperoxidase autoantibodies in vasculitis and other conditions
Locke, I.C., Leaker, B. and Cambridge, G. 1996. Characteristics of anti-myeloperoxidase autoantibodies in vasculitis and other conditions. American Society of Nephrology 29th Annual Meeting. New Orleans, USA 11/1996

Autoantibodies to neutrophil granule proteins: pathogenic potential in vasculitis?
Locke, I.C. and Cambridge, G. 1996. Autoantibodies to neutrophil granule proteins: pathogenic potential in vasculitis? British Journal of Biomedical Science. 53 (4), pp. 302-316.

A human monoclonal anti-myeloperoxidase antibody can prime human neutrophils in vitro
Cambridge, G., Leaker, B., Locke, I.C., Noronha-Dutra, A. and Epperlein, M. 1996. A human monoclonal anti-myeloperoxidase antibody can prime human neutrophils in vitro. American Society of Nephrology 29th Annual Meeting. New Orleans, USA 11/1996

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104. https://doi.org/10.1016/0304-3940(95)12088-L

Autoantibodies to myeloperoxidase in systemic sclerosis
Worral, J.G., Locke, I.C., Leaker, B., Black, C.M. and Cambridge, G. 1995. Autoantibodies to myeloperoxidase in systemic sclerosis. British Society for Rheumatology Heberden Round 1995. Keele University, UK 9/1995

An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase®
Locke, I.C., Ramsay, M.P., Hill, S.S. and Carpenter, B.G. 1993. An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase®. The Journal of Automatic Chemistry. 15 242749.

Automated analysis of the deoxyribonuclease active constituents of the medicament Varidase ®
Locke, I.C., Ramsey, M.P., Hill, S.S. and Carpenter, B.G. 1992. Automated analysis of the deoxyribonuclease active constituents of the medicament Varidase ®. IMLS XX Triennial Conference. Liverpool, UK 9/1992

Purification of the seed lectin from Dolichos biflorus by chromatofocusing
Rogers, D.J., Locke, I.C., Gibbs, R. and Carpenter, B.G. 1990. Purification of the seed lectin from Dolichos biflorus by chromatofocusing. 12th International Lectin Conference. University of Davis, USA 9/1990