Annexin A1 in the brain: undiscovered roles?

Solito, E., McArthur, S., Christian, H.C., Gavins, F.N.E., Buckingham, J.C. and Gillies, G.E. 2008. Annexin A1 in the brain: undiscovered roles? Trends in Pharmacological Sciences. 29 (3), pp. 135-42. doi:10.1016/j.tips.2007.12.003

TitleAnnexin A1 in the brain: undiscovered roles?
AuthorsSolito, E., McArthur, S., Christian, H.C., Gavins, F.N.E., Buckingham, J.C. and Gillies, G.E.
Abstract

Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.

JournalTrends in Pharmacological Sciences
Journal citation29 (3), pp. 135-42
ISSN0165-6147
Year2008
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.tips.2007.12.003
Publication dates
Published2008

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