Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles

McCormick, A.L., Basnett, P., Vecchiato, V., Wright, E., Noble, B., Marcello, E. and Paxinou, A. 2023. Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles. Frontiers in Nanotechnology. 5 1243056. https://doi.org/10.3389/fnano.2023.1243056

TitleDual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles
TypeJournal article
AuthorsMcCormick, A.L., Basnett, P., Vecchiato, V., Wright, E., Noble, B., Marcello, E. and Paxinou, A.
Abstract

Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a polyhydroxyalkanoate (PHA) producer. A cell-free bacterial supernatant, which is typically discarded after PHA extraction, was used to produce spherical AuNPs of 3.5 ± 1.5 nm in size as determined by Transmission Electron Microscopy (TEM) analysis. The AuNPs/PHA composite coating demonstrated antibacterial activity against Staphylococcus aureus 6538P, and antiviral activity, with a 75% reduction in viral infectivity against SARS-CoV-2 pseudotype virus.

Keywordspolyhydroxyalkanoates, gold nanoparticles, dual production, antimicrobial coatings, antibacterial, antiviral, SARS-CoV-2
Article number1243056
JournalFrontiers in Nanotechnology
Journal citation5
ISSN2673-3013
Year2023
PublisherFrontiers
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3389/fnano.2023.1243056
Web address (URL)https://doi.org/10.3389/fnano.2023.1243056
Publication dates
Published07 Sep 2023
ProjectLung-on-a-chip covid study
FunderHealth Innovation Network

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