| Title | Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles |
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| Type | Journal article |
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| Authors | McCormick, A.L., Basnett, P., Vecchiato, V., Wright, E., Noble, B., Marcello, E. and Paxinou, A. |
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| Abstract | Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a polyhydroxyalkanoate (PHA) producer. A cell-free bacterial supernatant, which is typically discarded after PHA extraction, was used to produce spherical AuNPs of 3.5 ± 1.5 nm in size as determined by Transmission Electron Microscopy (TEM) analysis. The AuNPs/PHA composite coating demonstrated antibacterial activity against Staphylococcus aureus 6538P, and antiviral activity, with a 75% reduction in viral infectivity against SARS-CoV-2 pseudotype virus. |
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| Keywords | polyhydroxyalkanoates, gold nanoparticles, dual production, antimicrobial coatings, antibacterial, antiviral, SARS-CoV-2 |
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| Article number | 1243056 |
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| Journal | Frontiers in Nanotechnology |
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| Journal citation | 5 |
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| ISSN | 2673-3013 |
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| Year | 2023 |
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| Publisher | Frontiers |
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| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
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| Digital Object Identifier (DOI) | https://doi.org/10.3389/fnano.2023.1243056 |
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| Web address (URL) | https://doi.org/10.3389/fnano.2023.1243056 |
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| Publication dates |
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| Published | 07 Sep 2023 |
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| Project | Lung-on-a-chip covid study |
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| Funder | Health Innovation Network |
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