|Title||Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate|
|Authors||McCormick, A.L., Brown, R.H., Cudkowicz, M.E., Al-Chalabi, A. and Garson, J.A.|
BACKGROUND: Retroviral involvement in amyotrophic lateral sclerosis (ALS) has been suspected for several years since the recognition that both murine and human retroviruses can cause ALS-like syndromes. Nonquantitative studies have demonstrated the retroviral enzyme reverse transcriptase (RT) in ALS patients' sera, but the amount and source of RT activity are unknown. We therefore developed a quantitative assay to study RT levels in ALS and examined the possibility that the recently discovered human gammaretrovirus XMRV (xenotropic MuLV-related virus) might be the source of the RT activity.
|Journal citation||70 (4), pp. 278-283|
|Publisher||American Academy of Neurology|
|Digital Object Identifier (DOI)||https://doi.org/10.1212/01.wnl.0000297552.13219.b4|
|Published||22 Jan 2008|