Population structure, antimicrobial resistance, and virulence factors of diabetic foot-associated E. coli

Teaching Breast Cancer in Undergraduate Science Courses: Innovative approaches to stimulate research interest and engagement
Liu, J.Y.W., McCormick, A.L., Sowter, H., Neofytou, M., Presneau, Nadège, Sengupta, D. and Tinworth, L. 2026. Teaching Breast Cancer in Undergraduate Science Courses: Innovative approaches to stimulate research interest and engagement. 15th European Breast Cancer Conference. Barcelona, Spain 25 - 27 Mar 2026 Elsevier.

RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex
Zhang, Rui, Yang, Yuyan, He, Chao, Zhang, Xin, Torraca, Vincenzo, Wang, Shen, Liu, Nan, Yang, Jiaren, Liu, Shicheng, Yuan, Jinglei, Gou, Dongzhi, Li, Shi, Dong, Xueying, Xie, Yufei, He, Junling, Bai, Hua, Hu, Mengyu, Liao, Zhiquan, Huang, Yuan, Lyu, Hao, Xiao, Shuai, Guo, Dong, Ali, Declan William, Michalak, M., Ma, C., Chen, X., Tang, J. and Zhou, C. 2023. RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex. Cell Death and Differentiation. 30, p. 2231–2248. https://doi.org/10.1038/s41418-023-01215-z

Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles
McCormick, A.L., Basnett, P., Vecchiato, V., Wright, E., Noble, B., Marcello, E. and Paxinou, A. 2023. Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles. Frontiers in Nanotechnology. 5 1243056. https://doi.org/10.3389/fnano.2023.1243056

Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish
Vincenzo Torraca, Dominik Brokatzky, Sydney L Miles, Charlotte E Chong, P Malaka De Silva, Stephen Baker, Claire Jenkins, Kathryn E Holt, Kate S Baker and Serge Mostowy 2023. Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish. The Journal of Infectious Diseases. 228 (8), pp. 1108-1118. https://doi.org/10.1093/infdis/jiad326

Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive Escherichia coli
Sydney L. Miles, Vincenzo Torraca, Zoe A. Dyson, Ana Teresa López-Jiménez, Ebenezer Foster-Nyarko, Damián Lobato-Márquez, Claire Jenkins, Kathryn E. Holt and Serge Mostowy 2023. Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive Escherichia coli. mBio. 14 (4). https://doi.org/10.1128/mbio.00882-23

Zebrafish null mutants of Sept6 and Sept15 are viable but susceptible to Shigella infection
Torraca, Vincenzo, Bielecka, Magdalena K., Gomes, Margarida C., Brokatzky, Dominik, Busch‐Nentwich, Elisabeth M. and Mostowy, S. 2023. Zebrafish null mutants of Sept6 and Sept15 are viable but susceptible to Shigella infection. Cytoskeleton. 80 (7-8), pp. 266-274. https://doi.org/10.1002/cm.21750

P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri
Yang W. Huan, Vincenzo Torraca, Russell Brown, Jidapha Fa-arun, Sydney L. Miles, Diego A. Oyarzún, Serge Mostowy and Baojun Wang 2023. P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri. ACS Synthetic Biology. 12 (3), pp. 709-721. https://doi.org/10.1021/acssynbio.2c00465

Septins promote caspase activity and coordinate mitochondrial apoptosis
Hoan Van Ngo, Stevens Robertin, Dominik Brokatzky, Magdalena K. Bielecka, Damián Lobato‐Márquez, Vincenzo Torraca and Serge Mostowy 2023. Septins promote caspase activity and coordinate mitochondrial apoptosis. Cytoskeleton. 80 (7/8), pp. 254-265. https://doi.org/10.1002/cm.21696

Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
Jones, A.R., Iacoangeli, A., Adey, B.N., Bowles, H., Shatunov, A., Troakes, C., Garson, J.A., McCormick, A.L. and Al‑Chalabi, A. 2022. Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex. Scientific Reports. 12 14171. https://doi.org/10.1038/s41598-022-18488-y

Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
Jones, Ashley R., Iacoangeli, Alfredo, Adey, Brett N., Bowles, Harry, Shatunov, Aleksey, Troakes, Claire, Garson, Jeremy A., McCormick, Adele L. and Al-Chalabi, Ammar 2022. Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex. Scientific Reports. 12 (1) 14171. https://doi.org/10.1038/s41598-022-18488-y

Editorial: Zebrafish Models for Human Disease Studies
Zang, L., Torraca, V., Shimada, Y. and Nishimura, N. 2022. Editorial: Zebrafish Models for Human Disease Studies. Frontiers in Cell and Developmental Biology. 10 861941. https://doi.org/10.3389/fcell.2022.861941

A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex.
Jones, A.R., Iacoangeli, A., Adey, B.N., Bowles, H., Shatunov, A, Troakes, C., Garson, J.A., McCormick, A.L. and Al‑Chalabi, A. 2021. A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex. Scientific Reports. 11 14283. https://doi.org/10.1038/s41598-021-93742-3

Editorial: Nucleic Acid-Associated Inflammation
Laguette, N., Langevin, C., Olagnier, D., Torraca, V., Vanpouille-Box, C. and Verrier, E.R. 2021. Editorial: Nucleic Acid-Associated Inflammation. Frontiers in Immunology. 12. https://doi.org/10.3389/fimmu.2021.791580

Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal
Frida Sommer, Vincenzo Torraca, Yufei Xie, Aliede E. in ‘t Veld, Joost Willemse and Annemarie H. Meijer 2021. Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal. Cell Reports. 35 (2) 109000. https://doi.org/10.1016/j.celrep.2021.109000

Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin ( Strongylocentrotus purpuratus ) Coelomic Fluid—Novel Insights into Echinodermata Biology
D'alessio, S., Buckley, K., Kraev, Igor, Hayes, P.M. and Lange, S. 2021. Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin ( Strongylocentrotus purpuratus ) Coelomic Fluid—Novel Insights into Echinodermata Biology. Biology. 10 (9) 866. https://doi.org/10.3390/biology10090866

Sea lice (Copepoda: Caligidae) from South Africa, with descriptions of two new species of Caligus
Hayes, P.M., Christison, K.W., Vaughan, D.B., Smit, N.J. and Boxshall, G.A. 2021. Sea lice (Copepoda: Caligidae) from South Africa, with descriptions of two new species of Caligus. Systematic Parasitology. 98, p. 369–397. https://doi.org/10.1007/s11230-021-09984-2

Elevated microRNA expression could be diagnostic biomarker for PDAC
Mortoglou, M., Arisan, D., Ferreira, T., McCormick, A.L. and Uysal Onganer, P. 2020. Elevated microRNA expression could be diagnostic biomarker for PDAC. Pancreatology. 20 (8) e19. https://doi.org/10.1016/j.pan.2020.10.015

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages
Rui Zhang, Monica Varela, Gabriel Forn-Cuní, Vincenzo Torraca, Michiel van der Vaart and Annemarie H. Meijer 2020. Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death and Disease. 11 277. https://doi.org/10.1038/s41419-020-2477-1

Shigella sonnei
Vincenzo Torraca, Kathryn Holt and Serge Mostowy 2020. Shigella sonnei. Trends in Microbiology. 28 (8), pp. P696-697. https://doi.org/10.1016/j.tim.2020.02.011

Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish
Sommer, Frida, Torraca, V., Kamel, Sarah M., Lombardi, Amber and Meijer, Annemarie H. 2020. Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish. Journal of Leukocyte Biology. 107 (2), pp. 185-203. https://doi.org/10.1002/jlb.2hi0119-006r

Chemokine Receptors and Phagocyte Biology in Zebrafish
Sommer, Frida, Torraca, V. and Meijer, Annemarie H. 2020. Chemokine Receptors and Phagocyte Biology in Zebrafish. Frontiers in Immunology. 11 325. https://doi.org/10.3389/fimmu.2020.00325

Supplementary RNAseq dataset files
Frida Sommer, Torraca, V. and Annemarie H. Meijer 2020. Supplementary RNAseq dataset files. Zenodo. https://doi.org/10.5281/zenodo.3833847

Analysis tools to quantify dissemination of pathology in zebrafish larvae
David R. Stirling, Oniz Suleyman, Eliza Gil, Philip M. Elks, Vincenzo Torraca, Mahdad Noursadeghi and Gillian S. Tomlinson 2020. Analysis tools to quantify dissemination of pathology in zebrafish larvae. Scientific Reports. 10 3149. https://doi.org/10.1038/s41598-020-59932-1

In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy
Håkon Høgset, Conor C. Horgan, James P. K. Armstrong, Mads S. Bergholt, Vincenzo Torraca, Qu Chen, Timothy J. Keane, Laurence Bugeon, Margaret J. Dallman, Serge Mostowy and Molly M. Stevens 2020. In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy. Nature Communications . 11 6172. https://doi.org/10.1038/s41467-020-19827-1

Morphological and molecular characterization of an African freshwater fish trypanosome, including its development in a leech vector
Smit, Nico J., Joubert, Adri, Lawton, Scott P., Hayes, Polly M. and Cook, Courtney A. 2020. Morphological and molecular characterization of an African freshwater fish trypanosome, including its development in a leech vector. International Journal for Parasitology. 50 (10 /11), pp. 921-929. https://doi.org/10.1016/j.ijpara.2020.06.004

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca
Magnadóttir, B., Uysal-Onganer, P., Kraev, I., Svansson, V., Hayes, P.M. and Lange, S. 2020. Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 34, p. 100676 100676. https://doi.org/10.1016/j.cbd.2020.100676

Response to the Letter from Garcia-Montojo and colleagues concerning our paper entitled, Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis.
Garson, J.A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E. and McCormick, A.L. 2019. Response to the Letter from Garcia-Montojo and colleagues concerning our paper entitled, Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 7 102. https://doi.org/10.1186/s40478-019-0756-9

Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation
Watson, Jayne L., Sanchez-Garrido, Julia, Goddard, Philippa J., Torraca, V., Mostowy, Serge, Shenoy, Avinash R. and Clements, Abigail 2019. Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation. mBio. 10 (6) e02654-19. https://doi.org/10.1128/mbio.02654-19

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence
Vincenzo Torraca, Myrsini Kaforou, Jayne Watson, Gina M. Duggan, Hazel Guerrero-Gutierrez, Sina Krokowski, Michael Hollinshead, Thomas B. Clarke, Rafal J. Mostowy, Gillian S. Tomlinson, Vanessa Sancho-Shimizu, Abigail Clements and Serge Mostowy 2019. Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence. PLOS Pathogens. 15 (12) e1008006. https://doi.org/10.1371/journal.ppat.1008006

RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection
Rougeot, Julien, Torraca, V., Zakrzewska, Ania, Kanwal, Zakia, Jansen, Hans J., Sommer, Frida, Spaink, Herman P. and Meijer, Annemarie H. 2019. RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in Immunology. 10 832. https://doi.org/10.3389/fimmu.2019.00832

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells
Annemarie Meijer and Torraca, V. 2019. CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells. Scientific Reports. 9 2399. https://doi.org/10.1038/s41598-019-38643-2

Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model
Masud, Samrah, Prajsnar, Tomasz K., Torraca, V., Lamers, Gerda E. M., Benning, Marianne, Van der Vaart, Michiel and Meijer, Annemarie H. 2019. Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15 (5), pp. 796-812. https://doi.org/10.1080/15548627.2019.1569297

Meeting report: Zebrafish Infection and Immunity 2019
Torraca, V., Gomes, Margarida C., Sarris, Milka and Mostowy, Serge 2019. Meeting report: Zebrafish Infection and Immunity 2019. Lab Animal. 48, pp. 284-287. https://doi.org/10.1038/s41684-019-0400-0

Biodiversity and Taxonomy of the Parasitic Crustacea
Boxshall, G. and Hayes, P. 2019. Biodiversity and Taxonomy of the Parasitic Crustacea. in: Smit, N.J., Bruce, N.L. and Hadfield, K.A. (ed.) Parasitic Crustacea Springer. pp. 73-134

Molecular evidence for resurrection of Plesiochorus elongatus (Digenea: Gorgoderidae): an urinary bladder parasite of sea turtles
Werneck, M.R., Hayes, P.M. and Lawton, S.P. 2019. Molecular evidence for resurrection of Plesiochorus elongatus (Digenea: Gorgoderidae): an urinary bladder parasite of sea turtles. Parasitology International. 71, pp. 180-185. https://doi.org/10.1016/j.parint.2019.03.015

Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis
Garson, J.A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E.F. and McCormick, A.L. 2019. Quantitative analysis of Human Endogenous Retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 7 45. https://doi.org/10.1186/s40478-019-0698-2

Molecular insights into the identification and phylogenetics of the cosmopolitan marine fish blood parasite, Haemogregarina bigemina (Adeleorina: Haemogregarinidae)
Hayes, P.M. and Smit, N.J. 2019. Molecular insights into the identification and phylogenetics of the cosmopolitan marine fish blood parasite, Haemogregarina bigemina (Adeleorina: Haemogregarinidae). International Journal for Parasitology: Parasites and Wildlife. 8, pp. 216-220. https://doi.org/10.1016/j.ijppaw.2019.01.006

Zebrafish Infection: From Pathogenesis to Cell Biology
Vincenzo Torraca and Serge Mostowy 2018. Zebrafish Infection: From Pathogenesis to Cell Biology. Trends in Cell Biology. 28 (2), pp. P143-156. https://doi.org/10.1016/j.tcb.2017.10.002

Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection
Willis, Alexandra R., Torraca, V., Gomes, Margarida C., Shelley, Jennifer, Mazon-Moya, Maria, Filloux, Alain, Lo Celso, Cristina and Mostowy, Serge 2018. Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection. mBio. 9 (3) e00933-18. https://doi.org/10.1128/mbio.00933-18

DNA barcoding of the medically important freshwater snail Physa acuta reveals multiple invasion events into Africa
Lawton, S.P., Allan, F., Hayes, P.M. and Smit, N.J. 2018. DNA barcoding of the medically important freshwater snail Physa acuta reveals multiple invasion events into Africa. Acta Tropica. 188, pp. 86-92. https://doi.org/10.1016/j.actatropica.2018.08.027

Post-translational Protein Deimination in Cod (Gadus morhua L.) Ontogeny: Novel Roles in Tissue Remodelling and Mucosal Immune Defences?
Magnadóttir, B., Hayes, P.M., Hristova, M., Bragason, B., Nicholas, A.P., Dodds, A.W., Gudmundsdottir, S. and Lange, S. 2018. Post-translational Protein Deimination in Cod (Gadus morhua L.) Ontogeny: Novel Roles in Tissue Remodelling and Mucosal Immune Defences? Developmental and Comparative Immunology. 87, pp. 157-170. https://doi.org/10.1016/j.dci.2018.06.006

Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny
Magnadóttir, B., Hayes, P.M., Gisladottir, B., Bragason, B., Hristova, M., Nicholas, A.P., Gudmundsdottir, S. and Lange, S. 2018. Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny. Developmental and Comparative Immunology. 87, pp. 1-11. https://doi.org/10.1016/j.dci.2018.05.014

Septins restrict inflammation and protect zebrafish larvae from Shigella infection
Maria J. Mazon-Moya, Alexandra R. Willis, Vincenzo Torraca, Laurent Boucontet, Avinash R. Shenoy, Emma Colucci-Guyon and Serge Mostowy 2017. Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLOS Pathogens. 13 (6) e1006467. https://doi.org/10.1371/journal.ppat.1006467

The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish
Torraca, V., Otto, Natasja A., Tavakoli-Tameh, Aidin and Meijer, Annemarie H. 2017. The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Developmental & Comparative Immunology. 67, pp. 57-65. https://doi.org/10.1016/j.dci.2016.10.014

The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme
Annemarie Meijer and Torraca, V. 2017. The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Scientific Reports. 7 45061. https://doi.org/10.1038/srep45061

Functional analysis reveals no transcriptional role for the glucocorticoid receptor beta-isoform in zebrafish
Chatzopoulou, Antonia, Schoonheim, Peter J., Torraca, V., Meijer, Annemarie H., Spaink, Herman P. and Schaaf, Marcel J.M. 2017. Functional analysis reveals no transcriptional role for the glucocorticoid receptor beta-isoform in zebrafish. Molecular and Cellular Endocrinology. 447, pp. 61-70. https://doi.org/10.1016/j.mce.2017.02.036

Modeling Infectious Diseases in the Context of a Developing Immune System
Masud, Samrah, Torraca, V. and Meijer, Annemarie H. 2017. Modeling Infectious Diseases in the Context of a Developing Immune System. Current Topics in Developmental Biology. 124, pp. 277-329. https://doi.org/10.1016/bs.ctdb.2016.10.006

Characterisation of tabanid flies (Diptera: Tabanidae) in South Africa and Zambia and detection of protozoan parasites they are harbouring
Taioe, M.O., Motloang, M.Y., Namangala, B., Chota, A., Molefe, N.I., Musinguzi, S.P, Suganuma, K., Hayes, P.M., Tsilo, T.J., Chainey, J., Inoue, N. and Thekisoe, O.M.M. 2017. Characterisation of tabanid flies (Diptera: Tabanidae) in South Africa and Zambia and detection of protozoan parasites they are harbouring. Parasitology. 144 (9), pp. 1162-1178. https://doi.org/10.1017/S0031182017000440

Correction: Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.
Sutherland, K.A., Parry, C.M., McCormick, A.L., Kapaata, A., Lyagoba, F., Kaleebu, P., Gilks, C.F., Goodall, R., Spyer, M., Kityo, C., Pillay, D., Gupta, R.K. and DART Virology Group 2016. Correction: Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial. PLoS ONE. 11 (6) e0157094. https://doi.org/10.1371/journal.pone.0157094

Septins and Bacterial Infection
Torraca, V. and Mostowy, Serge 2016. Septins and Bacterial Infection. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2016.00127

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection
Torraca, V., Cui, Chao, Boland, Ralf, Bebelman, Jan-Paul, van der Sar, Astrid M., Smit, Martine J., Siderius, Marco, Spaink, Herman P. and Meijer, Annemarie H. 2015. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease Models and Mechanisms. 8 (3), pp. 253-269. https://doi.org/10.1242/dmm.017756

Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.
Sutherland, K.A., Goodall, R.L., McCormick, A.L., Kapaata, A., Lyagoba, F., Kaleebu, P., Thiltgen, G., Gilks, C.F., Spyer, M., Kityo, C., Pillay, D., Dunn, D. and Gupta, R.K. 2015. Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa. AIDS Research and Human Retroviruses. 31 (10), pp. 1032-1037. https://doi.org/10.1089/aid.2015.0138

Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial
Sutherland, K.A., Parry, C.M., McCormick, A.L., Kapaata, A., Lyagoba, F., Kaleebu, P., Gilks, C.F., Goodall, R., Spyer, M., Kityo, C., Pillay, D., Gupta, R.K. and DART Virology Group 2015. Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial. PLoS ONE. 10 (9) e0137834. https://doi.org/10.1371/journal.pone.0137834

IL28B genotype predicts response to chronic hepatitis C triple therapy with telaprevir or boceprevir in treatment naïve and treatment-experienced patients other than prior partial- and null-responders
Calisti, G., Tavares, A., Macartney, M.J., McCormick, A.L., Labbett, W., Jacobs, M., Dusheiko, G., Rosenberg, W.M. and Haque, T. 2015. IL28B genotype predicts response to chronic hepatitis C triple therapy with telaprevir or boceprevir in treatment naïve and treatment-experienced patients other than prior partial- and null-responders. SpringerPlus. 4 (1). https://doi.org/10.1186/s40064-015-1137-x

Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5′UTR
McCormick, A.L., Macartney, M.J., Abdi-Abshir, I., Labbett, W., Smith, C., Irish, D., Webster, D.P. and Haque, T. 2015. Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5′UTR. Journal of Clinical Virology. 66 (May), pp. 56-59. https://doi.org/10.1016/j.jcv.2015.03.006

Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes
Chung, E., Ferns, R.B., He, M., Rigatti, R., Grant, P., McCormick, A.L., Bhagani, S., Webster, D.P., Nastouli, E. and Waters, L.J. 2015. Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes. Journal of Clinical Virology. 70 (Sept), pp. 63-66. https://doi.org/10.1016/j.jcv.2015.06.105

The utility of genotypic tropism testing in clinical practice
Wyatt, H., Herman, O., Macartney, M.J., Conibear, T., Garcia-Diaz, A., Booth, C., McCormick, A.L., Smith, C., Johnson, M., Irish, D. and Webster, D. 2015. The utility of genotypic tropism testing in clinical practice. International Journal of STD and AIDS. 26 (8), pp. 593-594. https://doi.org/10.1177/0956462414546917

Phenotypic and genotypic analyses to guide selection of reverse transcriptase inhibitors in second-line HIV therapy following extended virological failure in Uganda
R. L. Goodall, D. T. Dunn, T. Pattery, A. van Cauwenberge, P. Nkurunziza, P. Awio, N. Ndembi, P. Munderi, C. Kityo, C. F. Gilks, P. Kaleebu, D. Pillay, P. Kaleebu, D. Pillay, P. Awio, M. Chirara, D. Dunn, D. M. Gibb, C. Gilks, R. Goodall, A. Kapaata, M. Katuramur, F. Lyagoba, R. Magala, B. Magambo, K. Mataruka, A.L. McCormick, L. Mugarura, T. Musunga, M. Nabankkema, J. Nkalubo, P. Nkurunziza, C. Parry, V. Robertson, M. Spyer, D. Yirrell, H. Grosskurth, P. Munderi, G. Kabuye, D. Nsibambi, R. Kasirye, E. Zalwango, M. Nakazibwe, B. Kikaire, G. Nassuna, R. Massa, K. Fadhiru, M. Namyalo, A. Zalwango, L. Generous and P. Khauka 2014. Phenotypic and genotypic analyses to guide selection of reverse transcriptase inhibitors in second-line HIV therapy following extended virological failure in Uganda. Journal of Antimicrobial Chemotherapy. 69 (7), pp. 1938-1944. https://doi.org/10.1093/jac/dku052

Feasibility of testing and detection of HIV-1 drug resistance in proviral DNA
Booth, C., McCormick, A.L., Garcia-Diaz, A., Macartney, M., Youle, M., Johnson, M. and Webster, D. 2014. Feasibility of testing and detection of HIV-1 drug resistance in proviral DNA. BMC Infectious Diseases. 14 (Supplement 4) O25. https://doi.org/10.1186/1471-2334-14-s4-o25

Analysis of transmitted HIV-1 drug resistance using 454 ultra-deep-sequencing and the DeepChek(®)-HIV system.
Garcia-Diaz, A., McCormick, A.L., Booth, C., Gonzalez, D., Sayada, C., Haque, T., Johnson, M. and Webster, D. 2014. Analysis of transmitted HIV-1 drug resistance using 454 ultra-deep-sequencing and the DeepChek(®)-HIV system. Journal of the International AIDS Society. 17 (Suppl 3) 19752. https://doi.org/10.7448/ias.17.4.19752

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model
Torraca, V., Masud, S., Spaink, H.P. and Meijer, A.H. 2014. Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model. Disease Models and Mechanisms. 7 (7), pp. 785-797. https://doi.org/10.1242/dmm.015594

Morphological and molecular characterization of a marine fish trypanosome from South Africa, including its development in a leech vector
Hayes, P.M., Lawton, S.P., Smit, N.J., Gibson, W.C. and Davies, A.J. 2014. Morphological and molecular characterization of a marine fish trypanosome from South Africa, including its development in a leech vector. Parasites and Vectors. 7 (50). https://doi.org/10.1186/1756-3305-7-50

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology
Hayes, P.M., Varga, V., Olego-Fernandez, S., Sunter, J., Ginger, M.L., Gull, K. and Dr Michael Ginger 2014. Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology. Journal of Cell Biology. 206 (3), pp. 377-384. https://doi.org/10.1083/jcb.201312067

Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure
Macartney, M.J., Irish, D., Bridge, S.H., Garcia-Diaz, A., Booth, C., McCormick, A.L., Labbett, W., Smith, C., Velazquez, C., Tanwar, S., Trembling, P., Jacobs, M., Dusheiko, G., Rosenberg, W.M. and Haque, T. 2014. Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure. Antiviral Research. 105, pp. 112-7. https://doi.org/10.1016/j.antiviral.2014.02.019

Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4
McCormick, A.L., Wang, L., Garcia-Diaz, A., Macartney, M.J., Webster, D.P. and Haque, T. 2014. Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4 . Antiviral Therapy. 20 (1), pp. 81-85. https://doi.org/10.3851/IMP2763

The utility of different bioinformatics algorithms for genotypic HIV-1 tropism testing in a large clinical cohort with multiple subtypes
Bartlett, A., Macartney, M.J., Conibear, T., Feyertag, F., Smith, C., Johnson, M., Hyams, C., Garcia-Diaz, A., McCormick, A.L., Booth, C., Robertson, D. and Webster, D.P. 2014. The utility of different bioinformatics algorithms for genotypic HIV-1 tropism testing in a large clinical cohort with multiple subtypes. AIDS. 28 (11), pp. 1611-7. https://doi.org/10.1097/QAD.0000000000000288

Baseline drug-resistance mutations are detectable in HCV genes NS3 and NS5A but not NS5B in acute and chronic HIV-coinfected patients
McCormick, A.L., Moynihan, L., Macartney, M.J., Garcia-Diaz, A., Smith, C., Johnson, M., Rodger, A.J., Bhagani, S., Haque, T. and Webster, D. 2014. Baseline drug-resistance mutations are detectable in HCV genes NS3 and NS5A but not NS5B in acute and chronic HIV-coinfected patients. Antiviral Therapy. 20 (3), p. 2015. https://doi.org/10.3851/IMP2871

Robotic injection of zebrafish embryos for high-throughput screening in disease models
Spaink, Herman P., Cui, Chao, Wiweger, Malgorzata I., Jansen, Hans J., Veneman, Wouter J., Marin-Juez, Ruben, de Sonneville, Jan, Ordas, Anita, Torraca, V., van der Ent, Wietske, Leenders, William P., Meijer, Annemarie H., Snaar-Jagalska, B. Ewa and Dirks, Ron P. 2013. Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods. 62 (3), pp. 246-254. https://doi.org/10.1016/j.ymeth.2013.06.002

Evaluation of the Roche prototype 454 HIV-1 ultradeep sequencingdrug resistance assay in a routine diagnostic laboratory
Garcia-Diaz, A., Guerrero-Ramos, A., McCormick, A.L., Macartney, M.J., Conibear, T., Johnson, M., Haque, T. and Webster, D.P. 2013. Evaluation of the Roche prototype 454 HIV-1 ultradeep sequencingdrug resistance assay in a routine diagnostic laboratory. Journal of Clinical Virology. 58 (2), pp. 468-473. https://doi.org/10.1016/j.jcv.2013.07.009

Ultra-small graphene oxide functionalized with polyethylenimine (PEI) for very efficient gene delivery in cell and zebrafish embryos
Zhou, Xiang, Laroche, Fabrice, Lamers, Gerda E. M., Torraca, V., Voskamp, Patrick, Lu, Tao, Chu, Fuqiang, Spaink, Herman P., Abrahams, Jan Pieter and Liu, Zunfeng 2012. Ultra-small graphene oxide functionalized with polyethylenimine (PEI) for very efficient gene delivery in cell and zebrafish embryos. Nano Research. 5, pp. 703-709. https://doi.org/10.1007/s12274-012-0254-x

The genus Caligus Müller, 1785 (Copepoda: Siphonostomatoida): two new species from reef associated fishes in New Caledonia, and some nomenclatural problems resolved
Hayes, P.M., Justine, J.-L. and Boxshall, G. 2012. The genus Caligus Müller, 1785 (Copepoda: Siphonostomatoida): two new species from reef associated fishes in New Caledonia, and some nomenclatural problems resolved. Zootaxa. 3534, pp. 21-39.

Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1
McCormick, A.L., Parry, C.M., Crombe, A., Goodall, R.L., Gupta, R.K., Kaleebu, P., Kityo, C., Chirara, M., Towers, G.J. and Pillay, D. 2011. Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1. Antimicrobial Agents and Chemotherapy. 55 (4), pp. 1806-1809. https://doi.org/10.1128/AAC.01197-10

Three-dimensional visualisation of developmental stages of an apicomplexan fish blood parasite in its invertebrate host
Hayes, P.M., Wertheim, D.F., Smit, N.J., Seddon, A.M. and Davies, A.J. 2011. Three-dimensional visualisation of developmental stages of an apicomplexan fish blood parasite in its invertebrate host. Parasites and Vectors. 4 (219). https://doi.org/10.1186/1756-3305-4-219

Unexpected response of a captive blackeye thicklip, Hemigymnus melapterus (Bloch), from Lizard Island, Australia, exposed to juvenile isopods Gnathia aureamaculosa Ferreira & Smit
Hayes, P.M., Smit, N.J., Grutter, A.S. and Davies, A.J. 2011. Unexpected response of a captive blackeye thicklip, Hemigymnus melapterus (Bloch), from Lizard Island, Australia, exposed to juvenile isopods Gnathia aureamaculosa Ferreira & Smit. Journal of Fish Diseases. 34 (7), pp. 563-566. https://doi.org/10.1111/j.1365-2761.2011.01261.x

Full length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays
Gupta, R.K., Kohli, A., McCormick, A.L., Towers, G.J., Pillay, D. and Parry, C.M. 2010. Full length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays. AIDS. 24 (11), p. 1651–1655. https://doi.org/10.1097/QAD.0b013e3283398216

Lack of Minority K65RResistant Viral Populations Detected After Repeated Treatment Interruptions of Tenofovir/Zidovudine and Lamivudine in a Resource-Limited Setting
McCormick, A.L., Goodall, R.L., Joyce, A., Ndembi, N., Chirara, M., Katunduk, P., Walker, A.S., Yirrell, D.L., Gilks, C.F. and Pillay, D. 2010. Lack of Minority K65RResistant Viral Populations Detected After Repeated Treatment Interruptions of Tenofovir/Zidovudine and Lamivudine in a Resource-Limited Setting. Journal of Acquired Immune Deficiency Syndromes. 54 (2), pp. 215-216. https://doi.org/10.1097/QAI.0b013e3181cc1058

Viral Rebound and Emergence of Drug Resistance in the Absence of Viral Load Testing: A Randomized Comparison between Zidovudine-Lamivudine plus Nevirapine and Zidovudine-Lamivudine plus Abacavir
Ndembi, N., Goodall, R.L., Dunn, D.T., McCormick, A.L., Burke, A., Lyagoba, F., Munderi, P., Katundu, P., Kityo, C., Robertson, V., Yirrell, D.L., Walker, A.S., Gibb, D.M., Gilks, C.F., Kaleebu, P. and Pillay, D. 2010. Viral Rebound and Emergence of Drug Resistance in the Absence of Viral Load Testing: A Randomized Comparison between Zidovudine-Lamivudine plus Nevirapine and Zidovudine-Lamivudine plus Abacavir. The Journal of Infectious Diseases. 201 (1), pp. 106-113. https://doi.org/10.1086/648590

Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
McCormick, A.L., Brown, R.H., Cudkowicz, M.E., Al-Chalabi, A. and Garson, J.A. 2008. Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate. Neurology. 70 (4), pp. 278-283. https://doi.org/10.1212/01.wnl.0000297552.13219.b4

Pathology associated with parasitic juvenile gnathiids feeding on the puffadder shyshark, Haploblepharus edwardsii (Voight)
Hayes, P.M., Smit, N.J. and Davies, A.J. 2007. Pathology associated with parasitic juvenile gnathiids feeding on the puffadder shyshark, Haploblepharus edwardsii (Voight). Journal of Fish Diseases. 30 (1), pp. 55-58. https://doi.org/10.1111/j.1365-2761.2007.00777.x

A new fish haemogregarine from South Africa and its suspected dual transmission with trypanosomes by a marine leech
Hayes, P.M., Smit, N.J., Seddon, A.M., Wertheim, D.F. and Davies, A.J. 2006. A new fish haemogregarine from South Africa and its suspected dual transmission with trypanosomes by a marine leech. Folia Parasitologica. 53 (4), pp. 241-248. https://doi.org/10.14411/fp.2006.031

An interferon gamma-gp120 fusion delivered as a DNA vaccine induces enhanced priming
Nimal, S., McCormick, A.L., Thomas, M.S. and Heath, A.W. 2005. An interferon gamma-gp120 fusion delivered as a DNA vaccine induces enhanced priming. Vaccine. 23 (10), pp. 3984-3990. https://doi.org/10.1016/j.vaccine.2005.01.160

CD40 antibody as an adjuvant induces enhanced T cell responses
Carlring, J., Barr, T.A., McCormick, A.L. and Heath, A.W. 2004. CD40 antibody as an adjuvant induces enhanced T cell responses. Vaccine. 22 (25-26), p. 3323–3328. https://doi.org/10.1016/j.vaccine.2004.02.043

Haemogregarina bigemina (Protozoa : Apicomplexa : Adeleorina) – Past, present and future
Davies, A.J., Smit, N.J., Hayes, P.M., Seddon, A.M. and Wertheim, D.F. 2004. Haemogregarina bigemina (Protozoa : Apicomplexa : Adeleorina) – Past, present and future . Folia Parasitologica. 51 (2/3), pp. 99-108. https://doi.org/10.14411/fp.2004.015

A potent adjuvant effect of CD40 antibody attached to antigen
Barr, T.A., McCormick, A.L., Carlring, J. and Heath, A.W. 2003. A potent adjuvant effect of CD40 antibody attached to antigen. Immunology. 109 (1), pp. 87-92. https://doi.org/10.1046/j.1365-2567.2003.01634.x

Immunization with an Interferon-g–gp120 Fusion Protein Induces Enhanced Immune Responses to Human Immunodeficiency Virus gp120
McCormick, A.L., Thomas, M.S. and Heath, A.W. 2001. Immunization with an Interferon-g–gp120 Fusion Protein Induces Enhanced Immune Responses to Human Immunodeficiency Virus gp120. The Journal of Infectious Diseases. 184 (11), pp. 1423-1430. https://doi.org/10.1086/324371

Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
Parry, C.M., Kohli, A., Boinett, C.J., Towers, G.J., McCormick, A.L. and Pillay, D. 1999. Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1. Journal of Virology. 83 (18), pp. 9094-9101. https://doi.org/10.1128/JVI.02356-08

Cell Surface Expression of CD154 Inhibits Alloantibody Responses: A Mechanism for the Prevention of Autoimmune Responses against Activated T Cells?
McCormick, A.L., Santos-Argumedo, L., Thomas, M.S. and Heath, A.W. 1999. Cell Surface Expression of CD154 Inhibits Alloantibody Responses: A Mechanism for the Prevention of Autoimmune Responses against Activated T Cells? Cellular Immunology. 195 (2), pp. 157-161. https://doi.org/10.1006/cimm.1999.1528

Enhancement of immunogenicity of recombinant antigens by production of a cytokine-antigen fusion protein for vaccination
McCormick, A.L., Thomas, M.S. and Heath, A.W. 1997. Enhancement of immunogenicity of recombinant antigens by production of a cytokine-antigen fusion protein for vaccination. Biochemical Society Transactions. 25, p. 297S. https://doi.org/10.1042/bst025297s