KCC2 interacts with the dendritic cytoskeleton to promote spine development.

Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S.K., Lauri, S., Airaksinen, M.S., Keinänen, K., Khiroug, L., Saarma, M., Kaila, K. and Rivera, C. 2007. KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron. 56 (6), pp. P1019-1033. https://doi.org/10.1016/j.neuron.2007.10.039

TitleKCC2 interacts with the dendritic cytoskeleton to promote spine development.
TypeJournal article
AuthorsLi, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S.K., Lauri, S., Airaksinen, M.S., Keinänen, K., Khiroug, L., Saarma, M., Kaila, K. and Rivera, C.
Abstract

The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl− transport function, is a key factor in the maturation of dendritic spines. This morphogenic role of KCC2 in the development of excitatory synapses is mediated by structural interactions between KCC2 and the spine cytoskeleton. Here, the binding of KCC2 C-terminal domain to the cytoskeleton-associated protein 4.1N may play an important role. A more general conclusion based on our data is that KCC2 acts as a synchronizing factor in the functional development of glutamatergic and GABAergic synapses in cortical neurons and networks.

JournalNeuron
Journal citation56 (6), pp. P1019-1033
ISSN0896-6273
Year2007
PublisherCell Press
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuron.2007.10.039
PubMed ID18093524
Web address (URL)http://europepmc.org/abstract/med/18093524
Publication dates
Published20 Dec 2007

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