|Title||Non-typhoidal Salmonella Dublin: Why should we all care?|
Non-typhoidal Salmonella serovar Dublin is primarily associated with self-limiting gastrointestinal illness however, it has adapted to cause invasive disease in humans such as bacteremia and septicemia. In this study, whole genome sequencing (WGS) of human Salmonella Dublin strains revealed several virulence factors and mobile genetic elements (MGEs) that may contribute to bacterial virulence and enable the bacteria to cause invasive disease in humans including Gifsy-2 prophage, virulence plasmid and Salmonella pathogenicity islands; SPI-7 harbouring the Vi antigen, SPI-6 and SPI-19 harbouring two different T6SSs and the novel pathogenicity island ST313-GI. Interestingly, no genomic markers were detected that differentiate among invasive and non-invasive isolates therefore comparative transcriptomics will be carried out to identify differentially expressed genes in invasive strains compared with non-invasive strains aiming to identify novel virulence-attenuated strains with a potential for use as vaccine candidates for high-risk groups including children, elderly and immunocompromised patients.
|Conference||International Colloquium on Infectious Diseases, Epidemiology and Public Health (ICIEP 2022)|
|Accepted author manuscript|
|Published||31 Aug 2022|