Mohammed, M., Casjens, S.R., Millard, A.D., Harrison, C., Gannon, L. and Chattaway, M.A. 2023. Genomic analysis of Anderson typing phages of Salmonella Typhimrium: towards understanding the basis of bacteria-phage interaction. Scientific Reports. 13 10484. https://doi.org/10.1038/s41598-023-37307-6
| Title | Genomic analysis of Anderson typing phages of Salmonella Typhimrium: towards understanding the basis of bacteria-phage interaction |
|---|---|
| Type | Journal article |
| Authors | Mohammed, M., Casjens, S.R., Millard, A.D., Harrison, C., Gannon, L. and Chattaway, M.A. |
| Abstract | The Anderson phage typing scheme has been successfully used worldwide for epidemiological surveillance of Salmonella enterica serovar Typhimurium. Although the scheme is being replaced by whole genome sequence subtyping methods, it can provide a valuable model system for study of phage-host interaction. The phage typing scheme distinguishes more than 300 definitive types of Salmonella Typhimurium based on their patterns of lysis to a unique collection of 30 specific Salmonella phages. In this study, we sequenced the genomes of 28 Anderson typing phages of Salmonella Typhimurium to begin to characterize the genetic determinants that are responsible for the differences in these phage type profiles. Genomic analysis of typing phages reveals that Anderson phages can be classified into three different groups, the P22-like, ES18-like and SETP3-like clusters. Most Anderson phages are short tailed P22-like viruses (genus Lederbergvirus); but phages STMP8 and STMP18 are very closely related to the lambdoid long tailed phage ES18, and phages STMP12 and STMP13 are related to the long noncontractile tailed, virulent phage SETP3. Most of these typing phages have complex genome relationships, but interestingly, two phage pairs STMP5 and STMP16 as well as STMP12 and STMP13 differ by a single nucleotide. The former affects a P22-like protein involved in DNA passage through the periplasm during its injection, and the latter affects a gene whose function is unknown. Using the Anderson phage typing scheme would provide insights into phage biology and the development of phage therapy for the treatment of antibiotic resistant bacterial infections. |
| Article number | 10484 |
| Journal | Scientific Reports |
| Journal citation | 13 |
| ISSN | 2045-2322 |
| Year | 2023 |
| Publisher | Springer |
| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
| Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-023-37307-6 |
| PubMed ID | 37380724 |
| Web address (URL) | https://www.nature.com/articles/s41598-023-37307-6 |
| Publication dates | |
| Published | 28 Jun 2023 |
| Supplemental file | File Access Level Open (open metadata and files) |
| Funder | Quintin Hogg Trust |
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Mohammed, M. 2024. Marburg virus outbreak in Rwanda – what you need to know. The Conversation.
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Mohammed, M. 2024. Genomic Analysis of uropathogenic E. coli strains in Egypt. Microbiology Society Annual Conference 2024. Edinburgh 08 - 11 Apr 2024 Microbiology Society.
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Mohammed, M. 2024. Developing Phage Therapy by Investigating the Basis of Bacteria-Phage interaction. Research & Innovation 2024: Accelerating Future Drug Discovery. Manchester University, UK 20 - 21 Mar 2024
Dr Manal Mohammed comments on the spread of waterborne disease outbreaks during Gaza war
Mohammed, M. 2023. Dr Manal Mohammed comments on the spread of waterborne disease outbreaks during Gaza war. METRO.
Video: Join us at the University of Westminster to Fight superbugs!
Mohammed, M. 2023. Video: Join us at the University of Westminster to Fight superbugs!
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Mohammed, M. 2023. Air pollution linked with global rise in antibiotic resistance. The Conversation.
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Mohammed, M. 2023. Investigating the Dynamics of Host-Phage interaction: Towards Effective Phage Therapy! 5th International Conference on Applied Microbiology and Beneficial Microbes. London 09 - 10 Oct 2023
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Dr Manal Mohammed,has launched a campaign to raise awareness of superbugs (antibiotic resistant bacteria).
Mohammed, M. 2023. Dr Manal Mohammed,has launched a campaign to raise awareness of superbugs (antibiotic resistant bacteria).
Groupwork: Advantages & Disadvantages. A Students as Co-Creators Project
Mohammed, Manal, Agarkar, Ishwari and Begum, Kamnoor 2023. Groupwork: Advantages & Disadvantages. A Students as Co-Creators Project. University of Westminster.
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Difference Festival: Fighting superbugs
Mohammed, M. 2023. Difference Festival: Fighting superbugs. University of Westminster.
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Mohammed, M. 2023. Dr Manal Mohammed for The Conversation on the norovirus. The Conversation.
Dr Manal Mohammed for CNN on how often you should wear your clothes without washing them
Mohammed, M. 2023. Dr Manal Mohammed for CNN on how often you should wear your clothes without washing them. CNN.
Dr Manal Mohammed on the new Omicron BF.7 variant for The Conversation
Mohammed, M. 2022. Dr Manal Mohammed on the new Omicron BF.7 variant for The Conversation. The Conversation.
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Mohammed, M. 2022. Dr Manal Mohammed on the new Omicron BQ.1 and BQ.1.1 subvariants for The Conversation. The Conversation.
Genetic basis of phage-host interaction: Towards effective phage therapy of non-typhoidal Salmonella
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Mohammed, M. 2022. Dr Manal Mohammed on the new Omicron BA.4.6 variant for The Conversation. The Conversation.
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Mohammed, M. 2022. Dr Manal Mohammed for The Conversation on the new ‘bivalent’ COVID-19 booster vaccine. The Conversation.
Dr Manal Mohammed for The Conversation about why eating fermented food aids gut health
Mohammed, M. 2022. Dr Manal Mohammed for The Conversation about why eating fermented food aids gut health. The Conversation.
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Mohammed, M. 2021. Dr Manal Mohammed for Which? Travel about how to best protect your health when travelling. Which?.
Dr Manal Mohammed for CNN about how often you should wash your towels
Mohammed, M. 2021. Dr Manal Mohammed for CNN about how often you should wash your towels. CNN.
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Mohammed, M. 2021. CNN Health: How frequently should you wash your bed sheets? More often than you think. CNN.
Dr Manal Mohammed for The Conversation about bed hygiene.
Mohammed, M. 2021. Dr Manal Mohammed for The Conversation about bed hygiene. The Conversation.
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Mohammed, M. and Orzechowska, B. 2021. Investigating the difference in phage susceptibility among MDR Salmonella Typhimurium phage types DT104 and DT104b. Microbiology Society Annual Conference 2021. Online 26 - 30 Apr 2021
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Mohammed, M. 2021. Dr Manal Mohammed for The Conversation about the long-term problems of hand sanitiser. The Conversation.
Stop Superbugs!
Mohammed, M. 2021. Stop Superbugs!
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Mohammed, M. Forthcoming. Dr Manal Mohammed for The Independent on handwashing and hand-sanitisers. The Conversation.
Erratum for Cadel-Six et al., “Draft Genome Sequences of Salmonella enterica subsp. enterica Serovar Dublin Strains from Raw Milk Cheeses Characterized by Multilocus Variable-Number Tandem-Repeat Analysis Profiles Associated with Two Outbreaks in France”
Cadel-Six, Sabrina, Vignaud, Marie-Leone and Mohammed, Manal 2020. Erratum for Cadel-Six et al., “Draft Genome Sequences of Salmonella enterica subsp. enterica Serovar Dublin Strains from Raw Milk Cheeses Characterized by Multilocus Variable-Number Tandem-Repeat Analysis Profiles Associated with Two Outbreaks in France”. Microbiology Resource Announcements. 9 (7). https://doi.org/10.1128/mra.01590-19
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Mohammed, M. 2020. Viruses Can Also Wear the White Hats. BBVA OpenMind.
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Mohammed, M. 2020. Manal Mohammed for Which? about the common mistakes that people make when using hand sanitiser. Which?.
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Mohammed, M. 2020. Sputnik Radio in Edinburgh: UK Effort to Secure Pfizer Vaccine is Good News but Will Not Give Immediate Protection, Says Expert Dr Manal Mohammed. Sputnik Radio in Edinburgh with Craig Johnstone.
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Mohammed, M. 2020. Dr Manal Mohammed for The Conversation about the Pfizer vaccine and what to expect next. The Conversation.
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Mohammed, M. 2020. Dr Manal Mohammed for The Conversation on three major scientific controversies about coronavirus. The Conversation.
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Dr Manal Mohammed holds public lecture about superbugs at Westminster’s Difference Festival (27 February 2020)
Mohammed, M. 2020. Dr Manal Mohammed holds public lecture about superbugs at Westminster’s Difference Festival (27 February 2020).
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Mohammed, M. 2020. Dr Manal Mohammed for The Conversation about which kinds of sanitisers are most effective against coronavirus. The Conversation.
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Mohammed, M. 2020. Dr Manal Mohammed for the Daily Mail about whether face masks can help stop the spread of viruses (11 Feburary 2020).
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Mohammed, M. and Millard, A. 2020. The Conversation (Manal Mohammed & Andrew Millard): Antibiotic resistance: Scientists are reengineering viruses to cure bacterial infections. The Conversation.
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Mohammed, M. 2019. BBC Radio: Manal Mohammed for BBC Radio London on getting the flu at Christmas (17 December 2019).
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Mohammed, M. 2019. The Conversation: Kombucha, kimchi and yogurt: how fermented foods could be harmful to your health. The Conversation.
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Mohammed, M. 2019. The Conversation: Can surgical masks protect you from getting the flu? The Conversation.
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Mohammed, M. 2019. BBC Radio London: Dr Manal Mohammed discusses children’s personal hygiene as children go back to school (2 September 2019).
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Mohammed, M. 2019. ITV News: Dr Manal Mohammed discusses bacteria that are resistant to drugs.
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Mohammed, M. 2019. The Conversation: Non-thermal plasma: new technology could kill 99.9% of the deadly germs in the air. The Conversation.
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Mohammed, M. 2019. BBC News: Victoria Derbyshire: Dr Manal Mohammed Comments on Superbugs and Antibiotic Resistance.
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Six, S.C., Vignaud, M.L. and Mohammed, M. 2019. Draft Genome Sequences of Salmonella enterica subsp. enterica Serovar Dublin Strains from St. Nectaire and Morbier Cheeses Characterized by Multilocus Variable-Number Tandem-Repeat Analysis Profiles Associated with Two Fatal Outbreaks in France. Microbiology Resource Announcements. 8 (1) e01361-18. https://doi.org/10.1128/MRA.01361-18
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Mohammed, M. 2018. Novel Insights Into the prevention and Treatment of Invasive Salmonella Dublin. (1-2 November 2018): Invited speaker and congress moderator at the 7th European Clinical Microbiology congress. London, UK. 7th European Clinical Microbiology Congress. London, UK 01 - 02 Nov 2018
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Mohammed, M. 2018. Old school wins: outbreak investigation of foodborne salmonellosis. Atlas of Science.
Atlas of Science: Old School Wins: outbreak investigation of foodborne Salmonellosis
Mohammed, M. 2018. Atlas of Science: Old School Wins: outbreak investigation of foodborne Salmonellosis.
BBC Radio London: Dr Manal Mohammed talks about research finding 19 types of bacteria on cash and coins
Mohammed, M. 2018. BBC Radio London: Dr Manal Mohammed talks about research finding 19 types of bacteria on cash and coins.
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Mohammed, M. 2018. BBC Radio London: Dr Manal Mohammed talks about spread of germs in public spaces.
Keynote Speech: Towards Treatment and Prevention of Invasive Non-typhoidal Salmonella
Mohammed, M. 2018. Keynote Speech: Towards Treatment and Prevention of Invasive Non-typhoidal Salmonella. International Conference on Advanced Microbiology and Education. London, UK 14 - 16 Jun 2018
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Mohammed, M. 2017. Phage typing or CRISPR typing for epidemiological surveillance of Salmonella Typhimurium? BMC Research Notes. 10, p. 578 578. https://doi.org/10.1186/s13104-017-2878-0
Why should Britain Care about Salmonella Dublin?
Mohammed, M. 2017. Why should Britain Care about Salmonella Dublin?
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Mohammed, M., Le Hello, S., Leekitcharoenphon, P. and Hendriksen, R. 2017. Whole genome sequencing reveals the secrets of Salmonella Dublin invasome. European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Vienna, Austria 25 Apr - 21 Jul 2017
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Mohammed, M., Le Hello, S., Leekitcharoenphon, P. and Hendriksen, R. 2017. The invasome of Salmonella Dublin as revealed by whole genome sequencing . BMC Infectious Diseases. 17, p. 544 544. https://doi.org/10.1186/s12879-017-2628-x
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Mohammed, M. and Cormican, M. 2016. Whole Genome Sequencing Provides Insights into the Genetic Determinants of Invasiveness in Salmonella Dublin. Epidemiology and Infection. 144 (11), pp. 2430-2439. https://doi.org/10.1017/S0950268816000492
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Mohammed, M., Delappe, N., O'Connor, J., McKeown, P., Garvey, P. and Cormican, M. 2016. Whole genome sequencing provides an unambiguous link between Salmonella Dublin outbreak strain and a historical isolate. Epidemiology and Infection. 144 (3), pp. 576-581. https://doi.org/10.1017/S0950268815001636
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Mohammed, M. and Cormican, M. 2015. Whole genome sequencing provides possible explanations for the difference in phage susceptibility among two Salmonella Typhimurium phage types (DT8 and DT30) associated with a single foodborne outbreak. BMC Research Notes. 8, p. 728 728. https://doi.org/10.1186/s13104-015-1687-6
Salmonella occurrence and Enterobacteriaceae counts in pig feed ingredients and compound feed from feed mills in Ireland
Burns, A.M., Lawlor, P.G., Gardiner, G.E., McCabe, E.M., Walsh, D., Mohammed, M., Grant, J. and Duffy, G. 2015. Salmonella occurrence and Enterobacteriaceae counts in pig feed ingredients and compound feed from feed mills in Ireland. Preventive Veterinary Medicine. 121 (3-4), pp. 231-239. https://doi.org/10.1016/j.prevetmed.2015.07.002
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