NOX5: Molecular biology and pathophysiology

A combined bioinformatics and LC-MS-based approach for the development and benchmarking of a comprehensive database of Lymnaea CNS proteins
Sarah Wooller, Aikaterini Anagnostopoulou, Benno Kuropka, Michael Crossley, paul benjamin, Frances Pearl, Ildiko Kemenes, George Kemenes and Murat Eravci 2022. A combined bioinformatics and LC-MS-based approach for the development and benchmarking of a comprehensive database of Lymnaea CNS proteins. Journal of Experimental Biology. 225 (7) jeb243753. https://doi.org/10.1242/jeb.243753

Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS
Hatakeyama, D., Sunada, H., Totani, Y., Watanabe, T., Felletár, I., Fitchett, A., Eravci, M., Anagnostopoulou, A., Miki, R., Okada, A., Abe, N., Kuzuhara, T., Kemenes, I., Ito, E. and Kemenes, G. 2022. Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS. FASEB Journal. 36 (11) e22593. https://doi.org/10.1096/fj.202101225RR

Preprint: A combined bioinformatics and LC-MS based approach for the development and benchmarking of a comprehensive database for CNS proteins in Lymnaea stagnalis
Wooller, S., Anagnostopoulou, A., Kuropka, B., Crossley, M., Benjamin, P.R., Pearl, F., Kemenes, I., Kemenes, G. and Eravci, M. 2021. Preprint: A combined bioinformatics and LC-MS based approach for the development and benchmarking of a comprehensive database for CNS proteins in Lymnaea stagnalis. biorxiv.org. https://doi.org/10.1101/2021.05.03.442491

Preprint: Histone acetyltransferase activity of CREB-binding protein is essential for synaptic plasticity in Lymnaea
Hatakeyama, D., Sunada, H., Totani, Y., Watanabe, T., Felletár, I., Fitchett, A., Eravci, M., Anagnostopoulou, A., Miki, R., Kuzuhara, T., Kemenes, I., Ito, E. and Kemenes, G. 2021. Preprint: Histone acetyltransferase activity of CREB-binding protein is essential for synaptic plasticity in Lymnaea. biorxiv.org. https://doi.org/10.1101/2021.05.26.445902

Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel
Rhéure Alves-Lopes, Karla B. Neves, Aikaterini Anagnostopoulou, Francisco J. Rios, Silvia Lacchini, Augusto C. Montezano and Rhian M. Touyz 2020. Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel. Hypertension. 75, pp. 139-149. https://doi.org/10.1161/hypertensionaha.119.13861

Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells
Aikaterini Anagnostopoulou, Livia de Lucca Camargo, Daniel Rodrigues, Augusto C. Montezano and Rhian Touyz 2020. Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells. Scientific Reports. 10 17818. https://doi.org/10.1038/s41598-020-73751-4

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease
Rhian M. Touyz, Aikaterini Anagnostopoulou, Livia L. Camargo, Francisco J. Rios and Augusto C. Montezano 2019. Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease. Antioxidants and Redox Signaling. 30 (7), pp. 1027-1040. https://doi.org/10.1089/ars.2018.7583

NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function
Augusto C. Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J. Rios, Adam P. Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P. Gandara, Rheure Alves‐Lopes, Karla B. Neves, Maria Dulak‐Lis, Chet E. Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy and Rhian M. Touyz 2018. NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function. Journal of the American Heart Association. 7 (12) e009388. https://doi.org/10.1161/jaha.118.009388

Vascular smooth muscle contraction in hypertension
Rhian M Touyz, Rheure Alves-Lopes, Francisco J Rios, Livia L Camargo, Aikaterini Anagnostopoulou, Anders Arner and Augusto C Montezano 2018. Vascular smooth muscle contraction in hypertension. Cardiovascular Research. 114 (4), pp. 529-539. https://doi.org/10.1093/cvr/cvy023

The Serotonin Transporter Promotes a Pathological Estrogen Metabolic Pathway in Pulmonary Hypertension via Cytochrome P450 1B1
Anne Katrine Z. Johansen, Afshan Dean, Ian Morecroft, Katie Hood, Margaret Nilsen, Lynn Loughlin, Aikaterini Anagnostopoulou, Rhian M. Touyz, Kevin White and Margaret R. MacLean 2016. The Serotonin Transporter Promotes a Pathological Estrogen Metabolic Pathway in Pulmonary Hypertension via Cytochrome P450 1B1. Pulmonary Circulation. 6 (1), pp. 82-92. https://doi.org/10.1086/685023

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase
Aurelie Nguyen Dinh Cat, Tayze T. Antunes, Glaucia E. Callera, Ana Sanchez, Sofia Tsiropoulou, Maria G. Dulak-Lis, Aikaterini Anagnostopoulou, Ying He, Augusto C. Montezano, Frederic Jaisser and Rhian M. Touyz 2016. Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase. Diabetes. 65 (8), pp. 2392-2403. https://doi.org/10.2337/db15-1627

Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease
Rhian M. Touyz, Aikaterini Anagnostopoulou, Livia De Lucca Camargo and Augusto C. Montezano 2016. Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease. Circulation Research. 119 (9), pp. 969-971. https://doi.org/10.1161/circresaha.116.309854

Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox
Karla Bianca Neves, Aurelie Nguyen Dinh Cat, Rheure Alves Moreira Lopes, Francisco Jose Rios, Aikaterini Anagnostopoulou, Nubia Souza Lobato, Ana Maria de Oliveira, Rita C. Tostes, Augusto C. Montezano and Rhian M. Touyz 2015. Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox. Hypertension. 66 (3), pp. 657-666. https://doi.org/10.1161/hypertensionaha.115.05616

PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases
Martin Kolisek, Augusto C. Montezano, Gerhard Sponder, Aikaterini Anagnostopoulou, Juergen Vormann, Rhian M. Touyz and Joerg R. Aschenbach 2015. PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science. 129 (12), pp. 1143-1150. https://doi.org/10.1042/cs20150355

Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species
Anagnostopoulou, A., Hans-Peter Marti, James C. Fuscoe, Joshua C. Kwekel and Andreas Scherer 2014. Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. Nephrology Dialysis Transplantation. 29 (6), p. 1177–1185. https://doi.org/10.1093/ndt/gfu027

Development and Remodeling of the Vertebrate Blood-Gas Barrier
Anagnostopoulou, A., Makanya and Valentin Djonov 2013. Development and Remodeling of the Vertebrate Blood-Gas Barrier. BioMed Research International. 2013. https://doi.org/10.1155/2013/101597

Stat3 Activity Is Required for Gap Junctional Permeability in Normal Rat Liver Epithelial Cells
Mulu Geletu, Chrystele Chaize, Rozanne Arulanandam, Adina Vultur, Claudia Kowolik, Aikaterini Anagnostopoulou, Richard Jove and Leda Raptis 2009. Stat3 Activity Is Required for Gap Junctional Permeability in Normal Rat Liver Epithelial Cells. DNA and Cell Biology. 28 (7), pp. 319-327. https://doi.org/10.1089/dna.2008.0833

Electroporation of Adherent Cells In Situ for the Study of Signal Transduction and Gap Junctional Communication
Leda Raptis, Adina Vultur, Heather L. Brownell, Evangelia Tomai, Aikaterini Anagnostopoulou, Rozanne Arulanandam, Jun Cao and Kevin L. Firth 2008. Electroporation of Adherent Cells In Situ for the Study of Signal Transduction and Gap Junctional Communication. in: Shulin Li (ed.) Electroporation Protocols Humana Press. pp. 173-189

Synthesis, Characterization and Stat3 Inhibitory Properties of the Prototypical Platinum(IV) Anticancer Drug, [PtCl3(NO2)(NH3)2] (CPA-7)
Anagnostopoulou, A., Shalyn L. Littlefield, Michael C. Baird and Leda Raptis 2008. Synthesis, Characterization and Stat3 Inhibitory Properties of the Prototypical Platinum(IV) Anticancer Drug, [PtCl3(NO2)(NH3)2] (CPA-7). Inorganic Chemistry. 47 (7), p. 2798–2804. https://doi.org/10.1021/ic702057q

Differential effects of c-Ras upon transformation, adipocytic differentiation, and apoptosis mediated by the simian virus 40 large tumor antigen
Anagnostopoulou, A., Jun Cao, Rozanne Arulanandam, Adina Vultur and Leda Raptis 2007. Differential effects of c-Ras upon transformation, adipocytic differentiation, and apoptosis mediated by the simian virus 40 large tumor antigen. Biochemistry and Cell Biology. 85 (1), pp. 32-48. https://doi.org/10.1139/o06-187

Adenovirus E1A requires c-Ras for full neoplastic transformation or suppression of differentiation of murine preadipocytes
Anagnostopoulou, A., J. Cao, R. Arulanandam, A. Vultur and L. Raptis 2007. Adenovirus E1A requires c-Ras for full neoplastic transformation or suppression of differentiation of murine preadipocytes. Molecular Carcinogenesis. 46 (4), pp. 284-302. https://doi.org/10.1002/mc.20278

Examination of gap junctional, intercellular communication by in situ electroporation on two co-planar indium-tin oxide electrodes
Aikaterini Anagnostopoulou, Jun Cao, Adina Vultur, Kevin Firth and Leda Raptis 2007. Examination of gap junctional, intercellular communication by in situ electroporation on two co-planar indium-tin oxide electrodes. Molecular Oncology. 1, p. 226–231. https://doi.org/10.1016/j.molonc.2007.06.002

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells
Anagnostopoulou, A., Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S. Kim, Matthew Glenn, Andrew D. Hamilton and Leda Raptis 2006. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Letters. 242 (1), pp. 120-32. https://doi.org/10.1016/j.canlet.2005.10.047