Anagnostopoulou, A., Shalyn L. Littlefield, Michael C. Baird and Leda Raptis 2008. Synthesis, Characterization and Stat3 Inhibitory Properties of the Prototypical Platinum(IV) Anticancer Drug, [PtCl3(NO2)(NH3)2] (CPA-7). Inorganic Chemistry. 47 (7), p. 2798–2804. https://doi.org/10.1021/ic702057q
| Title | Synthesis, Characterization and Stat3 Inhibitory Properties of the Prototypical Platinum(IV) Anticancer Drug, [PtCl3(NO2)(NH3)2] (CPA-7) |
|---|---|
| Type | Journal article |
| Authors | Anagnostopoulou, A., Shalyn L. Littlefield, Michael C. Baird and Leda Raptis |
| Abstract | This paper describes a reinvestigation of the literature concerning the synthesis and structural characterization of the platinum(IV)-based anticancer drug known as CPA-7 and believed to be the compound fac-[PtCl3(NO2)(NH3)2]. CPA-7 has previously been extensively investigated for its ability to control tumor cell growth by inhibition of Stat3 signaling, but very little information is available concerning its synthesis or spectroscopic properties. A reproducible synthetic route is shown to produce an active material which is characterized by IR and 1H, 14N, 15N, and 195Pt NMR spectroscopy, and single crystal X-ray crystallography. The freshly prepared drug is obtained as a single isomer which may in fact be fac- or mer-[PtCl3(NO2)(NH3)2], but recrystallization resulted in a disordered crystal containing approximately equal amounts of the two geometric isomers. |
| Journal | Inorganic Chemistry |
| Journal citation | 47 (7), p. 2798–2804 |
| ISSN | 0020-1669 |
| 1520-510X | |
| Year | 2008 |
| Publisher | American Chemical Society |
| Digital Object Identifier (DOI) | https://doi.org/10.1021/ic702057q |
| Web address (URL) | http://dx.doi.org/10.1021/ic702057q |
| Publication dates | |
| Published | 01 Apr 2008 |