Title | Rapid effector function of varicella-zoster virus glycoprotein I-specific CD4+ T cells many decades after primary infection |
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Type | Journal article |
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Authors | Malavige, Gathsaurie Neelika, Jones, Louise, Black, Antony Paul and Ogg, Graham Stuart |
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Abstract | Glycoprotein I (gI) of varicella-zoster virus (VZV) contributes to viral virulence and is therefore a potentially important target for T cell control of viral replication. Persisting effector function of gI-specific T cells after primary infection has not been previously examined. We have shown that, many decades after infection, relatively high frequencies gI-specific interferon- gamma responses are detectable ex vivo and are dominated by CD4(+) T cells. We characterized the optimal peptide of the strongest response in our cohort showing restriction through DRB4*01. These findings are consistent with gI-specific CD4(+) T cell involvement in the control of VZV replication. |
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Journal | The Journal of Infectious Diseases |
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Journal citation | 195 (5), pp. 660-664 |
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ISSN | 0022-1899 |
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| 1537-6613 |
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Year | 2007 |
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Publisher | Oxford University Press |
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Digital Object Identifier (DOI) | https://doi.org/10.1086/511274 |
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PubMed ID | 17262706 |
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Publication dates |
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Published | 2007 |
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