Title | Pertussis in Lao PDR: Seroprevalence and disease |
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Type | Journal article |
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Authors | Kleine, Daria, Billamay, Somxay, Chanthavilay, Phetsavanh, Mongkhoune, Sodaly, Keokhamphoui, Chirapha, Souksakhone, Chanthala, Nouanthong, Phonethipsavanh, Khamphaphongphane, Bouaphan, Muller, Claude P. and Black, Antony P. |
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Abstract | Objectives Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods A total 3072 serum samples were obtained from different cohorts: children with documented vaccination, pre-schoolers, schoolchildren, blood donors, healthcare workers (HCWs), and pregnant women and paired cord blood. Samples were tested for anti-pertussis toxin IgG antibodies. A history of Bordetella pertussis exposure was defined according to antibody titres. Four hundred and seventy-five throat swabs and nasopharyngeal aspirates were analysed by PCR for the presence of B. pertussis in symptomatic children at the Children's Hospital in Vientiane. Results Overall pertussis seroprevalence was 57.5%. The prevalence of titres indicating acute infection or recent vaccination or infection/vaccination within the last 12 months ranged from 7.4% (100/1356) in adults to 21.4% (25/117) in pre-schoolers (age 1–5 years). B. pertussis was detected in 1.05% (5/475) of children with respiratory symptoms in Vientiane Capital. Conclusions It is suggested that routine childhood vaccination, in particular outreach, as well as vaccination of HCWs should be strengthened. A childhood booster and vaccination of pregnant mothers should be considered. There is also a need to improve reporting and to introduce pertussis testing in at least one central facility. |
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Journal | International Journal of Infectious Diseases |
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Journal citation | 95, pp. p282-287 |
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ISSN | 1201-9712 |
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Year | 2020 |
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Publisher | Elsevier |
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Publisher's version | License CC BY-NC-ND 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ijid.2020.03.074 |
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Publication dates |
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Published | 08 Apr 2020 |
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