Selective depletion of activated T cells: the CD40L-specific antibody experience

Hargreaves, R.E.G., Monk, N.J. and Jurcevic, S. 2004. Selective depletion of activated T cells: the CD40L-specific antibody experience. TRENDS in Molecular Medicine. 10 (3), pp. 130-135. https://doi.org/10.1016/j.molmed.2004.01.009

TitleSelective depletion of activated T cells: the CD40L-specific antibody experience
TypeJournal article
AuthorsHargreaves, R.E.G., Monk, N.J. and Jurcevic, S.
Abstract

Blocking the signal that provides co-stimulation to T cells during their encounter with antigen is thought to make T cells anergic or tolerant. Recently, treatments using CD40L-specific antibody, a co-stimulation blocking reagent, in primate transplant models indicated that this elegant concept could finally be turning into reality. In this context, the finding that CD40L-specific antibody acts through depletion of activated T cells rather than through co-stimulation blockade might seem undesirable. However, the selective removal of cells that are key effectors of immunopathology could provide a powerful tool for containing unwanted immune responses such as those that mediate autoimmune diseases and transplant rejection.

JournalTRENDS in Molecular Medicine
Journal citation10 (3), pp. 130-135
ISSN1471-499X
Year2004
PublisherCell Press
Digital Object Identifier (DOI)https://doi.org/10.1016/j.molmed.2004.01.009
PubMed ID15102356
Publication dates
PublishedMar 2004

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