Preprint: SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma

Brandon Bergsneider, Elise Bailey, Yusuf Ahmed, Namrata Gogineni, Derek Huntley and Ximena Montano 2024. Preprint: SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma. Authorea. https://doi.org/10.22541/au.170666000.06060674/v1

TitlePreprint: SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma
AuthorsBrandon Bergsneider, Elise Bailey, Yusuf Ahmed, Namrata Gogineni, Derek Huntley and Ximena Montano
Description

Introduction: Although most children experience minor symptoms from SARS-CoV-2 infection, some develop complications including MIS-C. Neuroblastoma patients may be at higher-risk of infection. We hypothesized that ACE2, CD147, PPIA and PPIB are poor-prognosis and SARS-CoV-2 infection biomarkers in neuroblastoma. Results: In-depth gene-expression-dataset statistical analysis showed ACE2, CD147, PPIA and PPIB high-expression significantly associated with poor-prognosis neuroblastomas with amplified MYCN, unfavourable-tumors and patients older than 18 months of age. Low-expression was associated with the NTRK1-PTPN6-TP53 module, a good-prognostic marker. Conclusion: ACE2, CD147, PPIA and PPIB high expression is associated with poor-prognosis neuroblastomas. These patients may be at higher-risk of SARS-CoV-2 infection.

Year2024
Output mediaAuthorea preprint
PublisherAuthorea
Publication dates
Published31 Jan 2024
Digital Object Identifier (DOI)https://doi.org/10.22541/au.170666000.06060674/v1
Web address (URL)https://doi.org/10.22541/au.170666000.06060674/v1

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