Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer

Montano, Ximena and Djamgoz, Mustafa B.A. 2004. Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. FEBS Letters. 571, pp. 1-3. https://doi.org/10.1016/j.febslet.2004.06.088

TitleEpidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer
TypeJournal article
AuthorsMontano, Ximena and Djamgoz, Mustafa B.A.
Abstract

Although cancer of the prostate (CaP) is the most commonly occurring cancer in males, there are major limitations in its diagnosis and long-term cure. Consequently, understanding the molecular mechanisms involved in the progression of CaP is of particular importance for production of pharmacological and biological agents to manage the disease. The development of the normal prostate is regulated by stromal–epithelial interactions via endocrine and paracrine factors, such as androgens and growth factors, which act as precise homeostatic regulators of cellular proliferation. Importantly, after a period of hormonal therapy, CaP shifts from an androgen-dependent to an androgen-independent state with a concomitant switch from paracrine to autocrine growth factor stimulation and subsequent upregulation of growth factor expression. Thus, growth factors and their receptors have a pivotal role in CaP. This is emphasized by current evidence obtained from clinical specimens as well as several in vitro and in vivo models strongly suggesting that epidermal growth factor and the neurotrophins (nerve growth factor, brain derived neurotrophin factor, neurotrophin-3 and neurotrophin-4/5) together with their tyrosine kinase receptors could play a very significant role in CaP progression.

JournalFEBS Letters
Journal citation571, pp. 1-3
ISSN0014-5793
Year2004
PublisherElsevier
Digital Object Identifier (DOI)https://doi.org/10.1016/j.febslet.2004.06.088
Publication dates
Published30 Jul 2004

Related outputs

Preprint: SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma
Brandon Bergsneider, Elise Bailey, Yusuf Ahmed, Namrata Gogineni, Derek Huntley and Ximena Montano 2024. Preprint: SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma. Authorea. https://doi.org/10.22541/au.170666000.06060674/v1

A Potential Prognostic Gene Signature Associated with p53-Dependent NTRK1 Activation and Increased Survival of Neuroblastoma Patients
Currie, David, Wong, Nicole, Zane, Isabelle, Rix, Tom, Vardakastanis, Marios, Claxton, Amelia, Ong, Karine K. V., Macmorland, William, Poivet, Arthur, Brooks, Anthony, Niola, Paola, Huntley, Derek and Montano, Ximena 2024. A Potential Prognostic Gene Signature Associated with p53-Dependent NTRK1 Activation and Increased Survival of Neuroblastoma Patients. Cancers. 16 (4) 722. https://doi.org/10.3390/cancers16040722

Analysis of SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB in datasets from non SARS-CoV-2 infected neuroblastoma patients, as potential prognostic and infection biomarkers in neuroblastoma
Bergsneider, B., Bailey, E., Ahmed, Y., Gogineni, N., Huntley, D. and Montano Hernandez, X. 2021. Analysis of SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB in datasets from non SARS-CoV-2 infected neuroblastoma patients, as potential prognostic and infection biomarkers in neuroblastoma. Biochemistry and Biophysics Reports. 27 101081. https://doi.org/10.1016/j.bbrep.2021.101081

The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma
Youssef, G., Gillett, C., Rampling, D., Chagtai, T., Virasami, A., Barton, J., Edwards, D., Sebire, N., Anderson, J. and Montano, X. 2019. The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma. Human Pathology. 86, pp. 182-192. https://doi.org/10.1016/j.humpath.2018.12.003

A Promyelocytic Leukemia Protein-Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma
Dvorkina, M., Nieddu, V., Chakelam, S., Pezzolo, A., Cantilena, S., Leite, A.P., Chayka, O., Regad, T., Pistorio, A., Sementa, A.R., Virasami, A., Barton, A., Montano, X., Lechertier, T., Brindle, N., Morgenstern, D., Lebras, M., Burns, A.J., Saunders N.J., Hodivala-Dilke, K., Bagella, L., De The, H., Anderson, J., Sebire, N., Pistoia, V., Sala, A. and Salomoni, P. 2016. A Promyelocytic Leukemia Protein-Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma. Clinical Cancer Research. 22 (13), pp. 3398-3409. https://doi.org/10.1158/1078-0432.CCR-15-2081

Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer
Youssef, G., Gillett, C., Agbaje, O., Crompton, T. and Montano Hernandez, X. 2014. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer. Modern Pathology. 27, pp. 361-374 23948750. https://doi.org/10.1038/modpathol.2013.129

Repression of SHP-1 Expression by p53 leads to trkA Tyrosine Phosphorylation and Suppression of Breast Cancer Cell Proliferation
Montano, Ximena 2009. Repression of SHP-1 Expression by p53 leads to trkA Tyrosine Phosphorylation and Suppression of Breast Cancer Cell Proliferation. Oncogene. 28, pp. 3787-3800. https://doi.org/10.1038/onc.2009.143

Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity
Ding, Y., Brackenbury, W.J., Uysal Onganer, P., Montano, Ximena, Porter, L.M., Bates, L.F. and Djamgoz, M.B.A. 2008. Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity. Journal of Cellular Physiology. 215 (1), pp. 77-81. https://doi.org/10.1002/jcp.21289

Analysis of trk A tyrosine kinase and p53 association
Browes, C., Rowe, J., Brown, A. and Montano, Ximena 2001. Analysis of trk A tyrosine kinase and p53 association. FEBS Letters. 497, pp. 20-25. https://doi.org/10.1016/s0014-5793(01)02429-2

Common amino acid sequence motifs in p53, 14-3-3 and Akt protein families
Montano, Ximena 2001. Common amino acid sequence motifs in p53, 14-3-3 and Akt protein families. FEBS Letters. 507 (2), pp. 237-240. https://doi.org/10.1016/S0014-5793(01)02903-9

c-abl is involved in the association of p53 and trk A
Montano, Ximena 2000. c-abl is involved in the association of p53 and trk A. Oncogene. 19, pp. 3032-3040. https://doi.org/10.1038/sj.onc.1203619

Permalink - https://westminsterresearch.westminster.ac.uk/item/w9967/epidermal-growth-factor-neurotrophins-and-the-metastatic-cascade-in-prostate-cancer


Share this

Usage statistics

6 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.