Understanding the Neuropsychological Implications of Klinefelter Syndrome in Pediatric Populations: Current Perspectives

Tragantzopoulou, P. and Giannouli, V. 2024. Understanding the Neuropsychological Implications of Klinefelter Syndrome in Pediatric Populations: Current Perspectives. Pediatric Reports. 16 (2), pp. 420-431. https://doi.org/10.3390/pediatric16020036

TitleUnderstanding the Neuropsychological Implications of Klinefelter Syndrome in Pediatric Populations: Current Perspectives
TypeJournal article
AuthorsTragantzopoulou, P. and Giannouli, V.
AbstractKlinefelter syndrome (KS), also known as 47,XXY, is a genetic disorder characterized by the presence of an extra X chromosome. Despite the prevalence of verbal learning disabilities, memory impairments, and executive function deficits in individuals with KS, comprehensive research on the neuropsychological profiles of affected children and adolescents remains limited. Additionally, KS has been associated with comorbid conditions such as depression, anxiety, schizophrenia, attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorders (ASDs). However, systematic investigations into the neuropsychological manifestations of KS in pediatric populations are scarce. Therefore, the primary objectives of this review are to provide an overview of key studies examining the neuropsychological profiles of children and adolescents with KS and to delineate the limitations and implications of existing research findings. By synthesizing available literature, this review aims to bridge the gap in understanding the cognitive and behavioral characteristics of children and adolescents with KS, shedding light on potential avenues for future research and clinical interventions. Ultimately, this review serves as a valuable resource for clinicians, researchers, policymakers, parents, and educators involved in the assessment and management of the neuropsychological aspects of Klinefelter syndrome in pediatric populations.
JournalPediatric Reports
Journal citation16 (2), pp. 420-431
ISSN2036-7503
Year2024
PublisherMDPI AG
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3390/pediatric16020036
Publication dates
Published25 May 2024
LicenseCC BY 4.0

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