Genomic biomarkers for patient selection and stratification: the cancer paradigm

Moschos, S.A. 2012. Genomic biomarkers for patient selection and stratification: the cancer paradigm. Bioanalysis. 4 (20), pp. 2499-2511.

TitleGenomic biomarkers for patient selection and stratification: the cancer paradigm
AuthorsMoschos, S.A.
Abstract

The revolution in disease diagnosis and treatment promised on the completion of the human genome project over a decade ago has materialized in the form of unified drug and biomarker discovery and development pipelines. This strategic shift has been principally catalyzed through success stories in the field of oncology, ushering in the era of personalized medicine. Thus, a number of molecular targets have also been demonstrated to be reliable markers for selecting patients wherein treatment can be efficacious. Perhaps more importantly, however, the late adoption of biomarker strategies has also rescued drug candidates from complete late-stage failure. This review examines the historical lessons of key challenges in translating biomarker assay information into strategic and clinically actionable decisions and assesses the impact of personalized genome sequencing in the future of companion diagnostic development and commercialization.

JournalBioanalysis
Journal citation4 (20), pp. 2499-2511
ISSN1757-6180
YearOct 2012
PublisherFuture Science
Digital Object Identifier (DOI)doi:10.4155/bio.12.241
Publication dates
PublishedOct 2012

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