Current concepts in Alzheimer's disease: a multidisciplinary review

Minati, L., Edginton, T.L., Bruzzone, M.G. and Giaconne, G. 2009. Current concepts in Alzheimer's disease: a multidisciplinary review. American Journal of Alzheimer's Disease and Other Dementias. 24 (2), pp. 95-121.

TitleCurrent concepts in Alzheimer's disease: a multidisciplinary review
AuthorsMinati, L., Edginton, T.L., Bruzzone, M.G. and Giaconne, G.
Abstract

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.

JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Journal citation24 (2), pp. 95-121
ISSN1533-3175
YearApr 2009
PublisherSage
Digital Object Identifier (DOI)doi:10.1177/1533317508328602
Publication dates
PublishedApr 2009

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