|Title||Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1|
Introduction: The ZFP36 family of post-transcriptional regulator proteins include ZFP36, ZFP36L1 and ZFP36L2. These proteins are post-transcriptional regulators of gene expression that bind to adenine uridine rich elements (AREs) in the 3’ untranslated region of mRNAs mediating RNA degradation. ZFP36L1 functions in late B cell development to negatively regulate plasma cell differentiation by targeting mRNAs of important proteins including BLIMP1 and BCL2. Previous “in silico”analysis suggested that ZFP36L1 also targeted CD38 mRNA and we report here on the results of in vitro experiments designed to test this.
|Conference||4th European Congress of Immunology|
|Web address (URL) of conference proceedings||http://www.eci-vienna2015.org/|