AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity.

Sidali, A., Teotia, Varsha, Solaiman, Nadeen Shaikh, Bashir, Nahida, Kanagaraj, Radhakrishnan, Murphy, J. and Surendranath, K. 2021. AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity. International Journal of Molecular Sciences. 23 (1) 96. https://doi.org/10.3390/ijms23010096

TitleAU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity.
TypeJournal article
AuthorsSidali, A., Teotia, Varsha, Solaiman, Nadeen Shaikh, Bashir, Nahida, Kanagaraj, Radhakrishnan, Murphy, J. and Surendranath, K.
AbstractGenome integrity must be tightly preserved to ensure cellular survival and to deter the genesis of disease. Endogenous and exogenous stressors that impose threats to genomic stability through DNA damage are counteracted by a tightly regulated DNA damage response (DDR). RNA binding proteins (RBPs) are emerging as regulators and mediators of diverse biological processes. Specifically, RBPs that bind to adenine uridine (AU)-rich elements (AREs) in the 3' untranslated region (UTR) of mRNAs (AU-RBPs) have emerged as key players in regulating the DDR and preserving genome integrity. Here we review eight established AU-RBPs (AUF1, HuR, KHSRP, TIA-1, TIAR, ZFP36, ZFP36L1, ZFP36L2) and their ability to maintain genome integrity through various interactions. We have reviewed canonical roles of AU-RBPs in regulating the fate of mRNA transcripts encoding DDR genes at multiple post-transcriptional levels. We have also attempted to shed light on non-canonical roles of AU-RBPs exploring their post-translational modifications (PTMs) and sub-cellular localization in response to genotoxic stresses by various factors involved in DDR and genome maintenance. Dysfunctional AU-RBPs have been increasingly found to be associated with many human cancers. Further understanding of the roles of AU-RBP in maintaining genomic integrity may uncover novel therapeutic strategies for cancer.
KeywordsAdenine-Uridine rich element
oncogenes
DNA damage response
cancer
post-transcriptional regulation
tumour suppressors
replication stress
RNA binding proteins
genome stability
Article number96
JournalInternational Journal of Molecular Sciences
Journal citation23 (1)
ISSN1422-0067
Year2021
PublisherMDPI
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms23010096
PubMed ID35008519
Web address (URL)https://doi.org/10.3390/ijms23010096
Publication dates
Published22 Dec 2021
Published22 Dec 2021
Published online22 Dec 2021
ProjectPGTaSFA\100027
FunderChildren with Cancer UK

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