STAT5 in Cancer and Immunity

A deep learning workflow for quantification of Micronuclei in DNA damage studies in cultured cancer cell lines: a proof of principle investigation
Anand Panchbhai, Munuse Ceyda Ishanzadeh, Smarana Pankanti, Ahmed Sidali, Nadeeen Solaiman, Radhakrishnan Kanagaraj, John J. Murphy and Kalpana Surendranath 2023. A deep learning workflow for quantification of Micronuclei in DNA damage studies in cultured cancer cell lines: a proof of principle investigation. Computer Methods and Programs in Biomedicine. 232 107447. https://doi.org/10.1016/j.cmpb.2023.107447

AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity.
Sidali, A., Teotia, Varsha, Solaiman, Nadeen Shaikh, Bashir, Nahida, Kanagaraj, Radhakrishnan, Murphy, J. and Surendranath, K. 2021. AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity. International Journal of Molecular Sciences. 23 (1) 96. https://doi.org/10.3390/ijms23010096

Prostate Cancer: The role of inflammation and chemokines
Rani, A., Dasgupta, P. and Murphy, J.J. 2019. Prostate Cancer: The role of inflammation and chemokines. American Journal of Pathology. 189 (11), pp. 2119-2137. https://doi.org/10.1016/j.ajpath.2019.07.007

Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy
Rani, A., Stebbing, J., Giamas, G. and Murphy, J.J. 2019. Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy. Frontiers in Endocrinology. 10 245. https://doi.org/10.3389/fendo.2019.00245

Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer
Ribas, R., Pancholi, S., Rani, A., Schuster, E., Guest, S., Nikitorowicz-Buniak, J., Simigdala, N., Thornhill, A., Avogadri-Connors, F., Cutler, R., Lalani, A., Dowsett, M., Johnston, S. and Martin, L. 2018. Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer. Breast Cancer Research. 20, p. 44 44. https://doi.org/10.1186/S13058-018-0983-1

HES1 in immunity and cancer
Rani, A., Greenlaw, R., Smith, R.A. and Galustian, C. 2016. HES1 in immunity and cancer. Cytokine & Growth Factor Reviews. 30, pp. 113-117. https://doi.org/10.1016/j.cytogfr.2016.03.010

Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer
López-Knowles, E., Wilkerson, P., Ribas, R., Anderson, H., Mackay, A., Ghazoui, Z., Rani, A., Osin, P., Nerurkar, A., Renshaw, L., Larionov, A., Miller, W., Dixon, J., Reis-Filho, J., Dunbier, A., Martin, L. and Dowsett, M. 2015. Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer. Breast Cancer Research. 17, p. 35 35. https://doi.org/10.1186/S13058-015-0532-0

Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1
Murphy, J.J. 2015. Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1. 4th European Congress of Immunology. Vienna 08 Sep 2015

The Notch target Hes1, is a STAT5 target gene with implications in cancer
Rani, A., Greenlaw, R., Galustian, C. and Murphy, J.J. 2015. The Notch target Hes1, is a STAT5 target gene with implications in cancer. 2015 Meeting of the ICIS in Bamberg, Germany, October 11th -14th. Bamberg, Germany Oct 2015 https://doi.org/10.1016/j.cyto.2015.08.214

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers
Ribas, R., Ghazoui, Z., Gao, Q., Pancholi, S., Rani, A., Dunbier, A., Dowsett, M. and Martin, L. 2014. Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers. Breast Cancer Research. 16, p. 447 447. https://doi.org/10.1186/s13058-014-0447-1

Post-Transcriptional Regulation of BCL2 mRNA by the RNA-Binding Protein ZFP36L1 in Malignant B Cells
Zekavati, A., Nasir, A., Alcaraz, A., Aldrovandi, M., Marsh, P., Norton, J.D. and Murphy, J.J. 2014. Post-Transcriptional Regulation of BCL2 mRNA by the RNA-Binding Protein ZFP36L1 in Malignant B Cells. PLoS ONE. 9 (7) e102625. https://doi.org/10.1371/journal.pone.0102625

ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA
Nasir, A., Norton, J.D., Baou, M., Zekavati, A., Bijlmakers, M.J., Thompson, S. and Murphy, J.J. 2012. ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA. PLoS ONE. 7 (12) e52187. https://doi.org/10.1371/journal.pone.0052187

AU-rich RNA binding proteins in hematopoiesis and leukemogenesis
Baou, M., Norton, J.D. and Murphy, J.J. 2011. AU-rich RNA binding proteins in hematopoiesis and leukemogenesis. Blood. 118 (22), pp. 5732-5740. https://doi.org/10.1182/blood-2011-07-347237

IL-2 Regulates Expression of C-MAF in Human CD4 T Cells
Rani, A., Afzali, B., Kelly, A., Tewolde-Berhan, L., Hacket, M., Kanhere, A., Pedroza-Pacheco, I., Bowen, H., Jurcevic, S., Jenner, R., Cousins, D., Ragheb, J., Lavender, P. and John, S. 2011. IL-2 Regulates Expression of C-MAF in Human CD4 T Cells. Journal of Immunology. 187 (7), pp. 3721-3729. https://doi.org/10.4049/jimmunol.1002354

Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells
Baou, M., Jewell, A.P., Muthurania, A., Wickremasinghe, R.G., Yong, K.L., Carr, R., Marsh, P. and Murphy, J.J. 2009. Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells. Leukemia. 23 (5), pp. 986-989. https://doi.org/10.1038/leu.2008.340

Post-transcriptional regulator protein ZFP36L1 targeting of Bcl-2 mRNA
Zekavati, A., Marsh, P. and Murphy, J.J. 2009. Post-transcriptional regulator protein ZFP36L1 targeting of Bcl-2 mRNA. 2nd European Congress of Immunology. Berlin, Germany 13 – 16 September 2009

Evidence for involvement of ZFP36L1 protein downregulation in differentiation of the murine BCL1 leukaemia cell line
Nasir, A., Roberts, H., Thompson, S. and Murphy, J.J. 2009. Evidence for involvement of ZFP36L1 protein downregulation in differentiation of the murine BCL1 leukaemia cell line. 2nd European Congress of Immunology. Berlin, Germany 13 – 16 September 2009

TIS11 family proteins and their roles in post-transcriptional gene regulation
Baou, M., Jewell, A.P. and Murphy, J.J. 2009. TIS11 family proteins and their roles in post-transcriptional gene regulation. Journal of Biomedicine and Biotechnology. 634520. https://doi.org/10.1155/2009/634520

Evidence for involvement of ZFP36L1 protein downregulation in differentiation of the murine BCL1 leukaemia cell line
Nasir, A., Roberts, H., Thompson, S. and Murphy, J.J. 2008. Evidence for involvement of ZFP36L1 protein downregulation in differentiation of the murine BCL1 leukaemia cell line. BSI Immunology Congress. Glasgow 17-21 November 2008

Mode of action of Rituximab in chronic lymphocytic leukaemia: activation of Tis11b, an inducer of mRNA instability and induction of apoptosis
Baou, M., Jewell, A.P., Yong, K.L. and Murphy, J.J. 2008. Mode of action of Rituximab in chronic lymphocytic leukaemia: activation of Tis11b, an inducer of mRNA instability and induction of apoptosis. in: Moreau, I.B. (ed.) Chronic lymphocytic leukemia: new research Nova Science Publishers. pp. 141-155