TIS11 family proteins and their roles in post-transcriptional gene regulation

Baou, M., Jewell, A.P. and Murphy, J.J. 2009. TIS11 family proteins and their roles in post-transcriptional gene regulation. Journal of Biomedicine and Biotechnology.

TitleTIS11 family proteins and their roles in post-transcriptional gene regulation
AuthorsBaou, M., Jewell, A.P. and Murphy, J.J.
Abstract

Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their

untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.

JournalJournal of Biomedicine and Biotechnology
ISSN1110-7243
Year2009
PublisherHindawi
Digital Object Identifier (DOI)doi:10.1155/2009/634520
Publication dates
Published2009
Page rangeArticle ID 634520

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