Production of paclitaxel by Fusarium solani isolated from Taxus celebica

Chakravarthi, B.V., Das, P., Surendranath, K., Karande, A.A. and Jayabaskaran, C. 2008. Production of paclitaxel by Fusarium solani isolated from Taxus celebica. Journal of Biosciences. 33 (2), pp. 259-267. https://doi.org/10.1007/s12038-008-0043-6

TitleProduction of paclitaxel by Fusarium solani isolated from Taxus celebica
AuthorsChakravarthi, B.V., Das, P., Surendranath, K., Karande, A.A. and Jayabaskaran, C.
Abstract

A fungus was isolated from the stem cuttings of Taxus celebica, which produced paclitaxel in liquid-grown cultures. The fungus was identified as Fusarium solani based on colony characteristics, morphology of conidia and the 26S rDNA sequence. Paclitaxel was identified by chromatographic and spectroscopic comparison with authentic paclitaxel and its cytotoxic activity towards Jurkat cells in vitro.

KeywordsPaclitaxel, Fusarium solani, Jurkat cells
JournalJournal of Biosciences
Journal citation33 (2), pp. 259-267
ISSN0250-5991
Year2008
PublisherIndian Academy of Sciences
Digital Object Identifier (DOI)https://doi.org/10.1007/s12038-008-0043-6
Publication dates
Published2008
FunderThe Indian Council of Medical Research (ICMR)

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