| Title | Environmental modulators of vascular physiology and inflammation |
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| Type | Journal article |
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| Authors | Seneviratne, A.N., Majumdar, A., Surendranath, K. and Miller, M.R. |
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| Abstract | Environmental factors play a crucial role in modulating vascular inflammation, contributing significantly to the development of atherosclerosis and cardiovascular disease. This review synthesizes current evidence on how various environmental exposures influence vascular function and inflammation, with a focus on pollutants such as particulate matter and chemical toxins like bisphenols and per- and polyfluoroalkyl substances. These environmental stressors can trigger oxidative stress, chronic inflammation and vascular dysfunction, potentially accelerating the progression of atherosclerosis. We also explore the protective effects of natural compounds and exposure to green spaces in dampening inflammation and reducing cardiovascular risk. By examining the complex interplay between traditional risk factors and environmental exposures, this work highlights the need for comprehensive public health strategies that address both individual lifestyle factors and broader environmental determinants of cardiovascular health. We underscore the importance of further research to elucidate the precise cellular and molecular mechanisms by which environmental factors influence vascular function, with the aim of developing targeted interventions to mitigate their harmful effects and promote cardiovascular well-being. |
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| Keywords | air pollution, cardiovascular disease, inflammation, medicinal plants, natural compounds,particulate matter |
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| Journal | Experimental Physiology |
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| Journal citation | 111 (2), pp. 321-334 |
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| ISSN | 0958-0670 |
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| 1469-445X |
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| Year | 2026 |
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| Publisher | Wiley |
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| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
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| Digital Object Identifier (DOI) | https://doi.org/10.1113/EP092309 |
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| PubMed ID | 40349311 |
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| Web address (URL) | https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP092309 |
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| Publication dates |
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| Published online | 11 May 2025 |
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| Published in print | 01 Feb 2026 |
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| Project | Gene Editors of the Future: A unique model for research-engaged education at the University of Westminster |
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