Dietary fats induce human monocyte activation in vitro

Bentley, C., Bejta, F., De Pascale, C., Avella, M., Wheeler-Jones, C.P.D., Botham, K.M. and Lawson, C. 2007. Dietary fats induce human monocyte activation in vitro. Biochemical Society Transactions. 35 (3), pp. 464-465. doi:10.1042/BST0350464

TitleDietary fats induce human monocyte activation in vitro
AuthorsBentley, C., Bejta, F., De Pascale, C., Avella, M., Wheeler-Jones, C.P.D., Botham, K.M. and Lawson, C.
Abstract

In early atherosclerosis the frequency of activated monocytes in the peripheral circulation is amplified, and migration of monocytes into the walls of the aorta and large arteries is increased, due partly to de novo expression or activation of monocyte adhesion molecules. Although there is increasing evidence that CMRs (chylomicron remnants) are strongly atherogenic, the outcomes of interactions between blood monocytes and circulating CMRs are not known. Here, we have studied the effects of CRLPs (CMR-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found in susceptible areas of the artery wall.

JournalBiochemical Society Transactions
Journal citation35 (3), pp. 464-465
ISSN0300-5127
Year2007
PublisherPortland Press
Digital Object Identifier (DOI)doi:10.1042/BST0350464
Publication dates
Published01 Jun 2007

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