Recent discoveries of influenza A drug target sites to combat virus replication

Patel, H. and Kukol, A 2016. Recent discoveries of influenza A drug target sites to combat virus replication. Biochemical Society Transactions. 44 (3), pp. 932-936. https://doi.org/10.1042/BST20160002

TitleRecent discoveries of influenza A drug target sites to combat virus replication
TypeJournal article
AuthorsPatel, H. and Kukol, A
Abstract

Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.

KeywordsInfluenza A, viral proteins, antiviral discovery, resistance, inhibitors
JournalBiochemical Society Transactions
Journal citation44 (3), pp. 932-936
ISSN0300-5127
Year2016
PublisherPortland Press
Digital Object Identifier (DOI)https://doi.org/10.1042/BST20160002
PubMed ID27284062
Web address (URL)https://portlandpress.com/biochemsoctrans/article/44/3/932/67548/Recent-discoveries-of-influenza-A-drug-target
Publication dates
Published09 Jun 2016

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