The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD

Westwood, S., Bozhilova, N., Criaud, M., Lam, Sheut-Ling, Lukito, S.D.A.W., Wallace-Hanlon, S., Kowalczyk, O.S., Kostara, A., Mathew, J., Wexler, B.E., Kadosh, R.C., Asherson, P. and Rubia, K. 2022. The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD. IBRO Neuroscience Reports. 12, pp. 55-64. https://doi.org/10.1016/j.ibneur.2021.12.005

TitleThe effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD
TypeJournal article
AuthorsWestwood, S., Bozhilova, N., Criaud, M., Lam, Sheut-Ling, Lukito, S.D.A.W., Wallace-Hanlon, S., Kowalczyk, O.S., Kostara, A., Mathew, J., Wexler, B.E., Kadosh, R.C., Asherson, P. and Rubia, K.
Abstract

Transcranial direct current stimulation (tDCS) is a possible alternative to psychostimulants in Attention-Deficit/Hyperactivity Disorder (ADHD), but its mechanisms of action in children and adolescents with ADHD are poorly understood. We conducted the first 15-session, sham-controlled study of anodal tDCS over right inferior frontal cortex (rIFC) combined with cognitive training (CT) in 50 children/adolescents with ADHD. We investigated the mechanisms of action on resting and Go/No-Go Task-based QEEG measures in a subgroup of 23 participants with ADHD (n, sham = 10; anodal tDCS = 13). We failed to find a significant sham versus anodal tDCS group differences in QEEG spectral power during rest and Go/No-Go Task performance, a correlation between QEEG and Go/No-Go Task performance, and changes in clinical and cognitive measures. These findings extend the non-significant clinical and cognitive effects in our sample of 50 children/adolescents with ADHD. Given that the subgroup of 23 participants would have been underpowered, the interpretation of our findings is limited and should be used as a foundation for future investigations. Larger, adequately powered randomized controlled trials should explore different protocols titrated to the individual and using comprehensive measures to assess cognitive, clinical, and neural effects of tDCS and its underlying mechanisms of action in ADHD.

JournalIBRO Neuroscience Reports
Journal citation12, pp. 55-64
ISSN2667-2421
Year2022
PublisherElsevier
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ibneur.2021.12.005
Web address (URL)https://kclpure.kcl.ac.uk/portal/en/publications/the-effect-of-transcranial-direct-current-stimulation-tdcs-combined-with-cognitive-training-on-eeg-spectral-power-in-adolescent-boys-with-adhd(0cc9372e-bd5c-4546-95ac-f2ff89149117).html
Publication dates
PublishedJun 2022
Published online24 Dec 2021

Related outputs

Clinical and cognitive effects of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders: a systematic review and meta-analysis.
Westwood, Samuel, Conti, Aldo Alberto, Tang, Wanjie, Xue, Shuang, Cortese, Samuele and Rubia, Katja 2023. Clinical and cognitive effects of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders: a systematic review and meta-analysis. Molecular Psychiatry. 28, pp. 4025-4043. https://doi.org/10.1038/s41380-023-02227-4

Computerized cognitive training in attention-deficit/hyperactivity disorder (ADHD): a meta-analysis of randomized controlled trials with blinded and objective outcomes
Samuel J. Westwood, Valeria Parlatini, Katya Rubia, Samuele Cortese, Edmund J. S. Sonuga-Barke, T. Banaschewski, D. Baeyens, S. Bölte, D. Brandeis, J. Buitelaar, S. Carucci, D. Coghill, D. Daley, M. Döpfner, M. Ferrin, C. Galera, C. Hollis, M. Holtmann, D. Purper-Ouakil, P. Nagy, P. Santosh, E. Simonoff, E. J. Sonuga-Barke, C. A. Soutullo, A. Stringaris, A. Thapar, S. van der Oord, B. J. van den Hoofdakker and A. Zuddas 2023. Computerized cognitive training in attention-deficit/hyperactivity disorder (ADHD): a meta-analysis of randomized controlled trials with blinded and objective outcomes. Molecular Psychiatry. 28, p. 1402–1414. https://doi.org/10.1038/s41380-023-02000-7

Effects of transcranial direct current stimulation in children and young people with psychiatric disorders: a systematic review
Gallop, Lucy, Westwood, Samuel J, Lewis, Yael, Campbell, Iain C and Schmidt, Ulrike 2023. Effects of transcranial direct current stimulation in children and young people with psychiatric disorders: a systematic review. European child & adolescent psychiatry. Advanced online publication. https://doi.org/10.1007/s00787-023-02157-0

Are Small Effects the Indispensable Foundation for a Cumulative Psychological Science? A Reply to Götz et al. (2022)
Primbs, M.A., Pennington, C.R., Lakens, D., Silan, M.A.A., Lieck, D.S.N., Forscher, P.S., Buchanan, E.M. and Westwood, S. 2023. Are Small Effects the Indispensable Foundation for a Cumulative Psychological Science? A Reply to Götz et al. (2022). Perspectives on Psychological Science. 18 (2), pp. 508-512. https://doi.org/10.1177/17456916221100420

Double-Blind, Sham-Controlled Randomized Trial Testing the Efficacy of fMRI Neurofeedback on Clinical and Cognitive Measures in Children With ADHD
Lam, Sheut-Ling, Criaud, Marion, Lukito, Steve, Westwood, Samuel J., Agbedjro, Deborah, Kowalczyk, Olivia S., Curran, Sarah, Barret, Nadia, Abbott, Chris, Liang, Holan, Simonoff, Emily, Barker, Gareth J., Giampietro, Vincent and Rubia, Katya 2022. Double-Blind, Sham-Controlled Randomized Trial Testing the Efficacy of fMRI Neurofeedback on Clinical and Cognitive Measures in Children With ADHD. American Journal of Psychiatry. 179 (12), pp. 947-958. https://doi.org/10.1176/appi.ajp.21100999

What senior academics can do to support reproducible and open research: a short, three-step guide
Kowalczyk, O., Lautarescu, A., Blok, E., Dall’Aglio, L. and Westwood, S. 2022. What senior academics can do to support reproducible and open research: a short, three-step guide. BMC Research Notes. 15 116. https://doi.org/10.1186/s13104-022-05999-0

Towards a culture of open scholarship: The role of pedagogical communities
Azevedo, F., Liu, M., Pennington, C.R., Pownall, M., Evans, T.R., Parsons, S., Elsherif, M.M., Micheli, L., Westwood, S.J. and Framework for Open, Reproducible Research Training (FORRT) 2022. Towards a culture of open scholarship: The role of pedagogical communities. BMC Research Notes. 15 75. https://doi.org/10.1186/s13104-022-05944-1

Towards a culture of open scholarship: the role of pedagogical communities.
Azevedo, F., Liu, Meng, Pennington, Charlotte R, Pownall, Madeleine, Evans, Thomas Rhys, Parsons, Sam, Elsherif, Mahmoud Medhat, Micheli, Leticia, Westwood, Samuel J and Framework for Open, Reproducible Research Training (FORRT) 2022. Towards a culture of open scholarship: the role of pedagogical communities. BMC Research Notes. 15 (1) 75. https://doi.org/10.1186/s13104-022-05944-1

What senior academics can do to support reproducible and open research: a short, three-step guide
Kowalczyk, O.S., Lautarescu, A., Blok, E., Dall’Aglio, L. and Westwood, S.J. 2022. What senior academics can do to support reproducible and open research: a short, three-step guide. BMC Research Notes. 15 116. https://doi.org/10.1186/s13104-022-05999-0

Systematic Review and Meta-analysis: Screening Tools for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.
Mulraney, Melissa, Arrondo, Gonzalo, Musullulu, Hande, Iturmendi-Sabater, Iciar, Cortese, Samuele, Westwood, Samuel J, Donno, Federica, Banaschewski, Tobias, Simonoff, Emily, Zuddas, Alessandro, Döpfner, Manfred, Hinshaw, Stephen P and Coghill, David 2021. Systematic Review and Meta-analysis: Screening Tools for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 61 (8), pp. 982-996. https://doi.org/10.1016/j.jaac.2021.11.031

Limits to tDCS effects in language: Failures to modulate word production in healthy participants with frontal or temporal tDCS
Westwood, S., Olson, A., Miall, C., Nappo, R. and Romani, C. 2017. Limits to tDCS effects in language: Failures to modulate word production in healthy participants with frontal or temporal tDCS. Cortex. 86, pp. 64-82. https://doi.org/10.1016/j.cortex.2016.10.016

Permalink - https://westminsterresearch.westminster.ac.uk/item/vq5y2/the-effect-of-transcranial-direct-current-stimulation-tdcs-combined-with-cognitive-training-on-eeg-spectral-power-in-adolescent-boys-with-adhd


Share this

Usage statistics

81 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.