Studies with type I aldolase to understand fructose intolerance and combat parasitic disease.

Dalby, A.R. and Littlechild, J.A. 1996. Studies with type I aldolase to understand fructose intolerance and combat parasitic disease. Journal of Pharmacy and Pharmacology. 48 (2), pp. 214-217. https://doi.org/10.1111/j.2042-7158.1996.tb07126.x

TitleStudies with type I aldolase to understand fructose intolerance and combat parasitic disease.
TypeJournal article
AuthorsDalby, A.R. and Littlechild, J.A.
Abstract

A structural study of the type I aldolases has been carried out to examine the isozyme specificity of these enzymes and the potential for designing specific inhibitors. Natural mutations in these aldolase enzymes are associated with haemolytic anaemia and fructose intolerance. It has also been proposed that inhibition of the parasitic version of the enzyme may provide a new lead in the design of drugs against malaria and sleeping sickness. X-ray crystallographic data is used with molecular modelling techniques to investigate the structural properties of these enzymes.

JournalJournal of Pharmacy and Pharmacology
Journal citation48 (2), pp. 214-217
ISSN0022-3573
2042-7158
Year1996
PublisherOxford University Press
Digital Object Identifier (DOI)https://doi.org/10.1111/j.2042-7158.1996.tb07126.x
PubMed ID8935175
Web address (URL)http://europepmc.org/abstract/med/8935175
Publication dates
PublishedFeb 1996

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