Developing stochastic models for spatial inference: bacterial chemotaxis

Yu, Y.D., Choi, Y., Teo, Y.Y. and Dalby, A.R. 2010. Developing stochastic models for spatial inference: bacterial chemotaxis. PLoS ONE. 5 (5), p. e10464.

TitleDeveloping stochastic models for spatial inference: bacterial chemotaxis
AuthorsYu, Y.D., Choi, Y., Teo, Y.Y. and Dalby, A.R.
Abstract

Background: Biological systems are inherently inhomogeneous and spatial effects play a significant role in processes such as pattern formation. At the cellular level proteins are often localised either through static attachment or via a dynamic equilibrium. As well as spatial heterogeneity many cellular processes exhibit stochastic fluctuations and so to make inferences about the location of molecules there is a need for spatial stochastic models. A test case for spatial models has been bacterial chemotaxis which has been studied extensively as a model of signal transduction. Results: By creating specific models of a cellular system that incorporate the spatial distributions of molecules we have shown how the fit between simulated and experimental data can be used to make inferences about localisation, in the case of bacterial chemotaxis. This method allows the robust comparison of different spatial models through alternative model parameterisations.

Conclusions: By using detailed statistical analysis we can reliably infer the parameters for the spatial models, and also to evaluate alternative models. The statistical methods employed in this case are particularly powerful as they reduce the need for a large number of simulation replicates. The technique is also particularly useful when only limited molecular level data is available or where molecular data is not quantitative.

JournalPLoS ONE
Journal citation5 (5), p. e10464
ISSN1932-6203
Year2010
PublisherPublic Library of Science
FileYu_et_al_2010_as_published.pdf
Digital Object Identifier (DOI)doi:10.1371/journal.pone.0010464
Publication dates
Published2010

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