Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome. : WestminsterResearch

Publication dates
Title	Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.
Type	Journal article
Authors	Gururajan, P., Gurumurthy, P., Nayar, P., Rao, G.S., Babu, R.S., Sarasabharati, A. and Cherian, K.M.
Abstract	Aims and objectives Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. Methods and results Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874–0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive. Conclusion Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.
Journal	Indian Heart Journal
Journal citation	64 (2), pp. 141-145
ISSN	0019-4832
Year	2012
Publisher	Elsevier
Publisher's version	1-s2.0-S0019483212600492-main.pdf License CC BY-NC-ND 4.0 File Access Level Open (open metadata and files)
Digital Object Identifier (DOI)	https://doi.org/10.1016/s0019-4832(12)60049-2
PubMed ID	22572488
Web address (URL)	http://europepmc.org/abstract/med/22572488
Published in print	Mar 2012
Published	Mar 2012

Related outputs

Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents
Srinivasa Nageswara, Rao G., Prema, G., Gururajan, P., Arumugam, S.B., Kirthivasan, V., Saibabu, R. and Cherian, K.M. 2011. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Indian Journal of Clinical Biochemistry. 26, pp. 22-27. https://doi.org/10.1007/s12291-010-0069-z

Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population.
Gururajan, P., Gurumurthy, P., Victor, D., Srinivasa Nageswara, R.ao G, Sai Babu, R., Sarasa Bharati, A. and Cherian, K.M. 2011. Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population. Biochemical Genetics. 49, pp. 96-103. https://doi.org/10.1007/s10528-010-9391-7

Serum E-selectin levels in Indian children and adolescents: relation to clinical and biochemical parameters.
Rao, G.S., Gurumurthy, P., Gururajan, P., Saibabu, R. and Cherian, K.M. 2011. Serum E-selectin levels in Indian children and adolescents: relation to clinical and biochemical parameters. Pediatrics International. 53 (1), pp. 40-45. https://doi.org/10.1111/j.1442-200x.2010.03191.x

Interleukin-8 levels with Clinical and Biochemical Parameters of Indian Children and Adolescents
Gururajan, P. 2010. Interleukin-8 levels with Clinical and Biochemical Parameters of Indian Children and Adolescents. Biomedicine.

Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India.
Gururajan P, Gurumurthy P, Nayar P, Chockalingam M, Bhuvaneshwari S, Babu S, Sarasabharati A, Victor D and Cherian KM 2010. Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India. Heart, Lung & Circulation. 19 (2), pp. P75-80. https://doi.org/10.1016/j.hlc.2009.07.003

Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents
Rao, S.N., Gurumurthy, G.P., Gururajan, P., Arumugam, S.B., Saibabu, Kirthivasan, V. and Cherian, K.M. 2010. Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents. Indian Journal of Pediatrics. 77, pp. 555-559. https://doi.org/10.1007/s12098-010-0061-x

Heart fatty acid binding protein (H-FABP) as a diagnostic biomarker in patients with acute coronary syndrome.
Gururajan, P., Gurumurthy, P., Nayar, P., Srinivasa Nageswara, Rao G., Babu, S. and Cherian, K.M. 2010. Heart fatty acid binding protein (H-FABP) as a diagnostic biomarker in patients with acute coronary syndrome. Heart, Lung & Circulation. 19 (11), pp. P660-664. https://doi.org/10.1016/j.hlc.2010.06.665

Serum myeloperoxidase: a novel biomarker for evaluation of patients with acute coronary syndrome.
Gururajan, P., Gurumurthy, P., Nayar, P., Babu, S., Sarasabharati, A., Victor, D. and Cherian, K.M. 2009. Serum myeloperoxidase: a novel biomarker for evaluation of patients with acute coronary syndrome. Heart Asia. 1 (1), pp. 41-46. https://doi.org/10.1136/ha.2009.000778

Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome.
Gururajan, P., Gurumurthy, P., Nayar, P., Babu, S., Sarasabharati, A., Victor, D. and Cherian, K.M. 2009. Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome. Indian Journal of Clinical Biochemistry. 24, pp. 229-233. https://doi.org/10.1007/s12291-009-0043-9

Permalink - https://westminsterresearch.westminster.ac.uk/item/w43w5/pregnancy-associated-plasma-protein-a-papp-a-as-an-early-marker-for-the-diagnosis-of-acute-coronary-syndrome

Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.

Related outputs

Share this

Usage statistics

Export as