Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.

Gururajan, P., Gurumurthy, P., Nayar, P., Rao, G.S., Babu, R.S., Sarasabharati, A. and Cherian, K.M. 2012. Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome. Indian Heart Journal. 64 (2), pp. 141-145. https://doi.org/10.1016/s0019-4832(12)60049-2

TitlePregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.
TypeJournal article
AuthorsGururajan, P., Gurumurthy, P., Nayar, P., Rao, G.S., Babu, R.S., Sarasabharati, A. and Cherian, K.M.
Abstract

Aims and objectives
Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS.

Methods and results
Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874–0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive.

Conclusion
Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.

JournalIndian Heart Journal
Journal citation64 (2), pp. 141-145
ISSN0019-4832
Year2012
PublisherElsevier
Publisher's version
License
CC BY-NC-ND 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1016/s0019-4832(12)60049-2
PubMed ID22572488
Web address (URL)http://europepmc.org/abstract/med/22572488
Publication dates
Published in printMar 2012
PublishedMar 2012

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