Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome.

Gururajan, P., Gurumurthy, P., Nayar, P., Babu, S., Sarasabharati, A., Victor, D. and Cherian, K.M. 2009. Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome. Indian Journal of Clinical Biochemistry. 24, pp. 229-233. https://doi.org/10.1007/s12291-009-0043-9

TitleIncreased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome.
TypeJournal article
AuthorsGururajan, P., Gurumurthy, P., Nayar, P., Babu, S., Sarasabharati, A., Victor, D. and Cherian, K.M.
Abstract

CD40-CD40L interaction plays a significant role in the pathogenesis of atherosclerosis and coronary artery disease. The clinical predictive value of Soluble CD40 Ligand (sCD40L) was evaluated in patients with Acute Coronary Syndrome (ACS) and Non-Cardiac Chest Pain (NCCP). The levels of serum soluble CD 40 ligand were measured by ELISA in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as NCCP. The levels of sCD40L were significantly increased in patients with ACS when compared to controls and NCCP. Receiver Operator Characteristic (ROC) Curve analysis showed sCD40L to be a good discriminator between patients with ischemic heart disease and patients without ischemic heart disease. The area under the curve was found to be 0.940 with 95% CI (0.915 to 0.960) (P<0.0001). The cut off value from the ROC curve was 2.99 ng/ml, above which sCD40L was considered to be positive. Combined assessment of sCD40L, Troponin I and CK-MB enhanced the risk prediction and early classification of patients. sCD40L seems to be a promising biomarker for identification and risk stratification for patients with acute coronary syndrome.

JournalIndian Journal of Clinical Biochemistry
Journal citation24, pp. 229-233
ISSN0974-0422
0970-1915
Year2009
PublisherSpringer
Digital Object Identifier (DOI)https://doi.org/10.1007/s12291-009-0043-9
PubMed ID23105840
Web address (URL)http://europepmc.org/abstract/med/23105840
Publication dates
PublishedJul 2009

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