Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India. : WestminsterResearch

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Title	Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India.
Type	Journal article
Authors	Gururajan P, Gurumurthy P, Nayar P, Chockalingam M, Bhuvaneshwari S, Babu S, Sarasabharati A, Victor D and Cherian KM
Abstract	Aims and objectives Elevated lipid profile and reduced antioxidants accelerate the formation of atherosclerosis. Multiple lines of evidences have suggested that increased lipids and low antioxidants are the major risk factors for the incidence of acute coronary syndrome. Oxidative stress evaluation is now considered as an index for the assessment of development of coronary artery disease. Therefore, we studied association of the levels of non-enzymic antioxidants and lipid profile in controls and patients with acute coronary syndrome (ACS). Methods and results The present study was carried out on 485 patients admitted to the emergency care unit, of whom 89 patients were diagnosed as non-cardiac chest pain (NCCP). Total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were analysed along with non-enzymic antioxidants such as vitamin C, vitamin E, reduced glutathione, MDA and protein thiol in controls and patients with ACS. The levels of total cholesterol and LDL-cholesterol were significantly raised in patients when compared to controls in contrast to lowering of HDL-cholesterol levels in patients than controls. Vitamin C, vitamin E, reduced glutathione, MDA and protein thiol levels were significantly lowered in patients than controls (p < 0.05). Conclusion Oxidative stress and lipid profile should be included as important markers in the early detection of acute coronary syndrome.
Journal	Heart, Lung & Circulation
Journal citation	19 (2), pp. P75-80
ISSN	1443-9506
Year	2010
Publisher	Elsevier
Digital Object Identifier (DOI)	https://doi.org/10.1016/j.hlc.2009.07.003
PubMed ID	19914867
Web address (URL)	http://europepmc.org/abstract/med/19914867
Published in print	Feb 2010

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Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India.

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