Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents

Rao, S.N., Gurumurthy, G.P., Gururajan, P., Arumugam, S.B., Saibabu, Kirthivasan, V. and Cherian, K.M. 2010. Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents. Indian Journal of Pediatrics. 77, pp. 555-559. https://doi.org/10.1007/s12098-010-0061-x

TitleClinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents
TypeJournal article
AuthorsRao, S.N., Gurumurthy, G.P., Gururajan, P., Arumugam, S.B., Saibabu, Kirthivasan, V. and Cherian, K.M.
Abstract

Objective
To investigate the relationship between serum leptin and lipid profile in South Indian School children and adolescents, and to evaluate the role of serum leptin in obese, overweight and congenital heart diseased children and adolescents; in South Indian population and its correlation with anthropometric and biochemical parameters.

Methods
The study included 185 school going children and adolescents. (52 obese, 49 overweight, 25 congenital heart disease children and adolescents, were compared with 59 normal controls, aged between 10–17 years). Anthropometric variables, lipid profile, fasting serum glucose were analyzed by autoanalyser and serum leptin by ELISA.

Results
Serum leptin levels were significantly elevated in obese and overweight children than in control children (36.88±18.60ng/mL, 20.64±11.18ng/mL vs 7.97±2.79ng/mL; p value <0.001), and decreased in congenital heart diseased children than in control children (6.20±4.23 ng/mL vs 7.97±2.79ng/mL; p value <0.005).

Conclusions
This study provides a good relationship between serum leptin levels and anthropometric and biochemical parameters, such as total cholesterol, triglycerides and LDL-cholesterol. We observed negative correlation between serum leptin and fasting glucose levels and HDL-cholesterol levels were found to be non-significant among the groups. Further studies with large sample size are needed to ascertain the relationship between serum leptin and lipid profile in different groups of children and adolescents.

JournalIndian Journal of Pediatrics
Journal citation77, pp. 555-559
ISSN0973-7693
0019-5456
Year2010
PublisherSpringer
Digital Object Identifier (DOI)https://doi.org/10.1007/s12098-010-0061-x
PubMed ID20401706
Web address (URL)http://europepmc.org/abstract/med/20401706
Publication dates
Published17 Apr 2010

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