The 8p12 myeloproliferative syndrome
O John-Olabode Sarah, A Oyekunle Anthony, A Adeyemo Titilope and S Akanmu Alani 2014. The 8p12 myeloproliferative syndrome. Nigerian Medical Journal. 55 (2), pp. 176-179. https://doi.org/10.4103/0300-1652.129669
O John-Olabode Sarah, A Oyekunle Anthony, A Adeyemo Titilope and S Akanmu Alani 2014. The 8p12 myeloproliferative syndrome. Nigerian Medical Journal. 55 (2), pp. 176-179. https://doi.org/10.4103/0300-1652.129669
Title | The 8p12 myeloproliferative syndrome |
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Authors | O John-Olabode Sarah, A Oyekunle Anthony, A Adeyemo Titilope and S Akanmu Alani |
Abstract | The occurrence of a myeloproliferative disorder in association with an aggressive lymphoproliferative disorder is a distinctly unusual phenomenon. We report a case of concurrent leukaemia-lymphoma syndrome characterized by a BCR/ABL-negative myeloproliferative disease, eosinophilia and a lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(8;9) (q12; p33), which indicated presence of FGFR1 gene translocations. 8p12 myeloproliferative syndrome (EMS) / stem cell leukaemia-lymphoma syndrome (SCLL) belongs to the tyrosine kinase fusion genes chronic myeloproliferative diseases. The patient was managed conservatively with hydroxyurea, allopurinol and blood component therapy. The patient eventually died of intracerebral haemorrhage due to severe thrombocytopaenia. |
Journal | Nigerian Medical Journal |
Journal citation | 55 (2), pp. 176-179 |
ISSN | 0300-1652 |
Year | 2014 |
Publisher | Wolters Kluwer |
Digital Object Identifier (DOI) | https://doi.org/10.4103/0300-1652.129669 |
Publication dates | |
Published | 31 Mar 2014 |
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