Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria

Adedoyin Dosunmu, Akinsegun Akinbami, Ebele Uche, Adewumi Adediran and Sarah John-Olabode 2016. Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria. Journal of Tropical Medicine. Volume 2016 4214387. https://doi.org/10.1155/2016/4214387

TitleElectrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria
TypeJournal article
AuthorsAdedoyin Dosunmu, Akinsegun Akinbami, Ebele Uche, Adewumi Adediran and Sarah John-Olabode
Abstract

Background. This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia.
Methods. A case-control, cross-sectional study was conducted amongst sickle cell patients attending the sickle cell clinic of Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done and were subjected to electrocardiography (ECG). The descriptive data were given as means ± standard deviation (SD). The differences were considered to be statistically significant when the p value obtained was <0.05. Results. A total of ninety-three sickle cell anaemia (SCA) patients and ninety haemoglobin AA (controls) were enrolled. There was no significant difference in the age of the participants with SCA and that of the controls but the body mass index was significantly higher in controls (𝑝 = 0.0001). Overall, 73.1% (68 of 93) had abnormal ECG while only 2 of 90 (2.2%) of controls had abnormal ECG.The common abnormalities observed were left ventricular hypertrophy, biventricular hypertrophy, and right ventricular hypertrophy. Conclusion. Patients with SCA in steady state tend to have normal heart rate but about 50% of them would have had ECG changes before the age of 20 years. ECG being a noninvasive test may be used to identify patients at risk for early intervention.

Article number4214387
JournalJournal of Tropical Medicine
Journal citationVolume 2016
ISSN1687-9686
1687-9694
Year2016
PublisherHindawi
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1155/2016/4214387
Publication dates
Published21 Sep 2016

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