• Journal article

Prevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study

Onwah, A Lawretta, Adeyemo, Titilope A, Adediran, Adewumi, John-olabode, Sarah and Akanmu, Alani S 2012. Prevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study. BMC Blood Disorders. 12 7. https://doi.org/10.1186/1471-2326-12-7

TitlePrevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study
TypeJournal article
AuthorsOnwah, A Lawretta, Adeyemo, Titilope A, Adediran, Adewumi, John-olabode, Sarah and Akanmu, Alani S
Abstract

Background
The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder has not been determined in our geographic area Nigeria.

Methods
A cross sectional survey was carried on apparently healthy Nigerians selected by multistage sampling technique from the cosmopolitan city of Lagos, Nigeria. Subjects enrolled into the study had 2-step screening for the presence, type and concentration of monoclonal band. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to Immunofixation. Subjects were also evaluated for Bence jones proteinuria, haematological and biochemical parameters.

Results
Four hundred and ten subjects with a mean age of 45.68 ± 10.3 years, a median of 45.00 years and a range of 20 to 80 years were enrolled into the study. MGUS was identified in only one (0.24 percent) of the 410 study subject. This subject was demonstrated to have a double monoclonal gammopathy; IgGλ at 16.9 g/L and IgAκ at 8.5 g/L. None of them including the sole subject with MGUS had a monoclonal urinary light chain.

Conclusion
Among residents of Lagos, Nigeria, MGUS was found in only 0.24% percent of apparently normal persons with a median age of 45 years. This suggests that MGUS which represents the earliest stage of monoclonal plasma/lymphoid cell proliferation is not a common finding in the relatively young population of Nigeria. Future epidemiologic studies dealing with plasma cell disorders in older people are required to carefully examine the relationship between environmental factors and prevalence of MGUS and its ultimate progression to MM.

Article number7
JournalBMC Blood Disorders
Journal citation12
ISSN2052-1839
Year2012
PublisherBMC
Publisher's version
License
CC BY 2.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1186/1471-2326-12-7
Publication dates
Published28 Jun 2012

Related outputs

Prognostic performance of pretreatment systemic immune-inflammation index in women with epithelial ovarian cancer
Kehinde S. Okunade, Sarah O. John-Olabode, Adaiah P. Soibi-Harry, Austin C. Okoro, Adebola A. Adejimi, Iyabo Y. Ademuyiwa, Benedetto Osunwusi, Hameed Adelabu and Omolola Salako 2023. Prognostic performance of pretreatment systemic immune-inflammation index in women with epithelial ovarian cancer. Future Science OA. 9 (10) FSO897. https://doi.org/10.2144/fsoa-2023-0108

An Overview of HPV Screening Tests to Improve Access to Cervical Cancer Screening Amongst Underserved Populations: From Development to Implementation
Kehinde S. Okunade, Adebola A. Adejimi, Sarah O. John-Olabode, Yusuf A. Oshodi and Ayodeji A. Oluwole 2022. An Overview of HPV Screening Tests to Improve Access to Cervical Cancer Screening Amongst Underserved Populations: From Development to Implementation. Risk Management and Healthcare Policy. 15, pp. 1823-1830. https://doi.org/10.2147/rmhp.s296914

Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria
Sarah O. John-Olabode, Kehinde S. Okunade, Ayorinde James, Gbenga Olorunfemi, Obiefuna I. Ajie, Akinniyi A. Osuntoki and Alani S. Akanmu 2021. Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria. Journal of Blood Medicine. 12, pp. 307-312. https://doi.org/10.2147/jbm.s308997

Impact of Mobile Technologies on Cervical Cancer Screening Practices in Lagos, Nigeria (mHealth-Cervix): A Randomized Controlled Trial
Kehinde S. Okunade, Adaiah Soibi-Harry, Sarah John-Olabode, Adebola A. Adejimi, Matthew J. Allsop, Tonia C. Onyeka, Godwin O. Akaba, Yusuf A. Oshodi, Omolola Salako, Aloy O. Ugwu, Ayodeji Adefemi, Rose I. Anorlu and Jonathan S. Berek 2021. Impact of Mobile Technologies on Cervical Cancer Screening Practices in Lagos, Nigeria (mHealth-Cervix): A Randomized Controlled Trial. JCO Global Oncology. 7, pp. 1418-1425. https://doi.org/10.1200/go.21.00258

Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial
Okunade, K.S., Olowoselu, O.F., John-Olabode, S., Hassan, B.O., Akinsola, O.J., Nwogu, C.M., Ugwu, A.O., Moses, O.E., Rabiu, K.A., Ajepe, A., Adenekan, M.A., Adejimi, A.A., Akanmu, S.A. and Kanki, P.J. 2021. Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial. International Journal of Gynecology & Obstetrics. 153 (3), pp. 533-541. https://doi.org/10.1002/ijgo.13514

Awareness and practice of cord blood donation by pregnant women in Lagos Nigeria: Practice implication for future cord blood transplantation in Nigeria
John-Olabode, S.O., Okunade, K.S., Ajie, I.O., Olorunfemi, G. and Oyedeji, O.A. 2021. Awareness and practice of cord blood donation by pregnant women in Lagos Nigeria: Practice implication for future cord blood transplantation in Nigeria. Annals of African Medicine. 20 (1), pp. 24-30. https://doi.org/10.4103/aam.aam_9_20

Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes
Nwogu, C., Okunade, K., Adenekan, M., Sekumade, A., John-Olabode, S. and Oluwole, A. 2020. Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes. Annals of African Medicine. 19 (2), pp. 113-118. https://doi.org/10.4103/aam.aam_41_19

Prevalence of Rhesus C and D Alloantibodies among Rhesus-Negative Women of Child Bearing Age at a Tertiary Hospital in South-West Nigeria
Otomewo, L., John-Olabode, S., Okunade, K., Olorunfemi, G. and Ajie, I. 2020. Prevalence of Rhesus C and D Alloantibodies among Rhesus-Negative Women of Child Bearing Age at a Tertiary Hospital in South-West Nigeria. Nigerian Journal of Clinical Practice. 23 (12), pp. 1759-1766. https://doi.org/10.4103/njcp.njcp_114_20

Prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer
Okunade, K., Dawodu, O., Adenekan, M., Nwogu, C.M., Awofeso, O., Ugwu, A.O., Salako, O., John-Olabode, S., Olowoselu, O. and Anorlu, R. 2020. Prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer. Nigerian Journal of Clinical Practice. 23 (8), pp. 1141-1147. https://doi.org/10.4103/njcp.njcp_134_19

Effects of selenium supplementation on pregnancy outcome and disease progression in HIV-infected pregnant women in Lagos, Nigeria: Study protocol for a randomised, double-blind, placebo-controlled trial
Okunade, K.S., John-Olabode, S., Akinsola, O.J., Akinajo, O., Akanmu, S.A. and Kanki, P.J. 2019. Effects of selenium supplementation on pregnancy outcome and disease progression in HIV-infected pregnant women in Lagos, Nigeria: Study protocol for a randomised, double-blind, placebo-controlled trial. Medicine. 98 (3) e12735. https://doi.org/10.1097/md.0000000000012735

Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria
Okunade, K.S., Olowoselu, O.F., Osanyin, G.E., John-Olabode, S., Akanmu, S.A. and Anorlu, R.I. 2018. Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria. International Journal of Gynecology & Obstetrics. 142 (2), pp. 207-213. https://doi.org/10.1002/ijgo.12508

Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria
Adedoyin Dosunmu, Akinsegun Akinbami, Ebele Uche, Adewumi Adediran and Sarah John-Olabode 2016. Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria. Journal of Tropical Medicine. Volume 2016 4214387. https://doi.org/10.1155/2016/4214387

Impact of HIV infection and zidovudine therapy on RBC parameters and urine methylmalonic acid levels
Adediran, A., Osunkalu, V., Wakama, T., John-Olabode, S., Akinbami, A., Uche, E. and Akanmu, S. 2016. Impact of HIV infection and zidovudine therapy on RBC parameters and urine methylmalonic acid levels. Interdisciplinary Perspectives on Infectious Diseases. Volume 2016 5210963. https://doi.org/10.1155/2016/5210963

Factors influencing CD4 cell count in HIV-positive pregnant women in a secondary health center in lagos, nigeria
Akinbami, A.A., Ajibola, S.O., Uche, E.I., Dosunmu, A.O., Adediran, A. and Sobande, A. 2015. Factors influencing CD4 cell count in HIV-positive pregnant women in a secondary health center in lagos, nigeria. HIV/AIDS - Research and Palliative Care. 7, pp. 115-118. https://doi.org/10.2147/hiv.s80137

Hemoglobin and ferritin concentrations in subjects with metabolic syndrome
Adediran, A., Uche, E., Akinbami, A., Dada, A., Wakama, T., Damulak, D., Ajibola, S. and Okwegbuna, O. 2015. Hemoglobin and ferritin concentrations in subjects with metabolic syndrome. Nutrition and Metabolic Insights. 8, pp. 15-19. https://doi.org/10.4137/nmi.s23302

A Rare Case of Nonsecretory Multiple Myeloma in Lagos, Nigeria: A Case Report and Literature Review
Uche, E., Akinbami, A., John-Olabode, S., Dosunmu, A. and Odesanya, M. 2015. A Rare Case of Nonsecretory Multiple Myeloma in Lagos, Nigeria: A Case Report and Literature Review. Case Reports in Medicine. Volume 2015 648069. https://doi.org/10.1155/2015/648069

Quality of sleep in an HIV population on antiretroviral therapy at an urban tertiary centre in Lagos, Nigeria
Oshinaike, O., Akinbami, A., Ojelabi, O., Dada, A., Dosunmu, A. and John-Olabode, S. 2014. Quality of sleep in an HIV population on antiretroviral therapy at an urban tertiary centre in Lagos, Nigeria. Neurology Research International. Volume 2014 298703. https://doi.org/10.1155/2014/298703

The relationship between red blood cell distribution width and blood pressure in patients with type 2 diabetes mellitus in Lagos, Nigeria.
Dada, O.A., Uche, E., Akinbami, A., Odesanya, M., John-Olabode, S., Adediran, A., Oshinaike, O., Ogbera, A.O., Okunoye, O., Arogundade, O., Aile, K. and Ekwere, T. 2014. The relationship between red blood cell distribution width and blood pressure in patients with type 2 diabetes mellitus in Lagos, Nigeria. Journal of Blood Medicine. 5, pp. 185-189. https://doi.org/10.2147/jbm.s67989

Mycosis Fungoides: Case Report and Literature Review
Akinbami, A., Bodunrin, O., John-Olabode, S., Adediran, A., Oshinaike, O., Uche, E., Ismail, A., Dosunmu, A., Odesanya, M., Dada, A. and Okunoye, O. 2014. Mycosis Fungoides: Case Report and Literature Review. Clinical Medicine Insights: Case Reports. 2014 7. https://doi.org/10.4137/ccrep.s15724

Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria
Sarah John-Olabode, Akinsegun Akinbami, Idris Durojaiye, Adedoyin Dosunmu, Adewumi Adediran, Olajumoke Oshinaike, Ebele Uche, Akinola Dada, Mojeed Odesanya and Olaitan Okunoye 2014. Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria. Journal of Blood Medicine. 5, pp. 169-174. https://doi.org/10.2147/jbm.s67912

Mean platelet volume and platelet counts in type 2 Diabetes: Mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria
Akinbami Akinsegun, Dada Akinola Olusola, John-Olabode Sarah, Oshinaike Olajumoke, Adediran Adewumi, Odesanya Majeed, Ogbera Anthonia, Uche Ebele, Okunoye Olaitan, Arogundade Olanrewaju and Aile Kingsley 2014. Mean platelet volume and platelet counts in type 2 Diabetes: Mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria. The Pan African Medical Journal. 18 42. https://doi.org/10.11604/pamj.2014.18.42.3651

The Kikuchi-Fujimoto Disease in Nigeria: A Case Report and Literature Review
Akinbami, A., Odesanya, M., Soyemi, S., John-Olabode, S., Adediran, A., Oshinaike, O., Uche, E., Dosunmu, A., Dada, A. and Okunoye, O. 2014. The Kikuchi-Fujimoto Disease in Nigeria: A Case Report and Literature Review. Case Reports in Medicine. Volume 2014 171029. https://doi.org/10.1155/2014/171029

Knowledge, Attitude and practices of HIV post exposure prophylaxis amongst health workers in Lagos University teaching hospital
Ajibola, S., Akinbami, A., Elikwu, C., Odesanya, M. and Uche, E. 2014. Knowledge, Attitude and practices of HIV post exposure prophylaxis amongst health workers in Lagos University teaching hospital. The Pan African Medical Journal. 19 172. https://doi.org/10.11604/pamj.2014.19.172.4718

Prevalence of significant bacteriuria among symptomatic and asymptomatic homozygous sickle cell disease patients in a tertiary hospital in Lagos, Nigeria
Akinbami, A.A., John-olabode, S., Bode-Shojobi, I., Oshinaike, O., Adediran, A., Ojelabi, O., Osikomaiya, B., Ismail, K., Uche, E; and Moronke, R. 2014. Prevalence of significant bacteriuria among symptomatic and asymptomatic homozygous sickle cell disease patients in a tertiary hospital in Lagos, Nigeria. Nigerian Journal of Clinical Practice. 17 (2), pp. 163-167. https://doi.org/10.4103/1119-3077.127441

Gestational thrombocytopaenia among pregnant women in Lagos, Nigeria
John-olabode, Sarah, Akinbami, Akinsegun, Rabiu, Kabiru, Adewunmi, Adeniyi, Dosunmu, Adedoyin, Adewumi, Adediran, Osikomaiya, Bodunrin and Ismail, Kamal 2014. Gestational thrombocytopaenia among pregnant women in Lagos, Nigeria. Nigerian Medical Journal. 55 (2), pp. 139-143. https://doi.org/10.4103/0300-1652.129647

Cluster of differentiation 4+ cell count mean value, reference range and its influencing factors in Human Immunodeficiency Virus-seronegative pregnant women in Lagos
Akinbami, A.A., Dosunmu, A.O., Adediran, A., Adewunmi, A.A., Rabiu, K.A., Osunkalu, V., John-olabode, S., Uche, E.I. and Adelekan, A, 2014. Cluster of differentiation 4+ cell count mean value, reference range and its influencing factors in Human Immunodeficiency Virus-seronegative pregnant women in Lagos. Nigerian Medical Journal. 55 (2), pp. 116-120. https://doi.org/10.4103/0300-1652.129640

Knowledge, Attitude and Practice of Blood Conservation Strategies amongst Physicians’ in Tertiary Hospitals
John-Olabode, S. 2014. Knowledge, Attitude and Practice of Blood Conservation Strategies amongst Physicians’ in Tertiary Hospitals. International Blood Research & Reviews. 2 (3), pp. 121-131. https://doi.org/10.9734/IBRR/2014/8906

The 8p12 myeloproliferative syndrome
O John-Olabode Sarah, A Oyekunle Anthony, A Adeyemo Titilope and S Akanmu Alani 2014. The 8p12 myeloproliferative syndrome. Nigerian Medical Journal. 55 (2), pp. 176-179. https://doi.org/10.4103/0300-1652.129669

Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria
Durojaiye, Idris, Akinbami, Akinsegun, Dosunmu, Adedoyin, John-olabode, Sarah, Adediran, Adewumi, Uche, Ebele, Oshinaike, Olajumoke, Odesanya, Majeed, Dada, Akinola and Okunoye, Olaitan 2014. Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria. The Pan African Medical Journal. 17 301. https://doi.org/10.11604/pamj.2014.17.301.4075

Serum ferritin levels in adults with sickle cell disease in Lagos, Nigeria
Akinbami, A.A., Dosunmu, A.O., Adediran, A.A., Oshinaike, O.O., Osunkalu, V.O., John-olabode, S. and Arogundade, O.M. 2013. Serum ferritin levels in adults with sickle cell disease in Lagos, Nigeria. Journal of Blood Medicine. 2013:4, pp. 59-63. https://doi.org/10.2147/jbm.s42212

Prevalence of priapism and its awareness amongst male homozygous sickle cell patients in Lagos
Adediran, Adewumi, Wright, Kikelomo, Akinbami, Akinsegun, Dosunmu, Adedoyin, Oshinaike, Olajumoke, Osikomaiya, Bodunrin and John-olabode, Sarah 2013. Prevalence of priapism and its awareness amongst male homozygous sickle cell patients in Lagos. Advances in Urology. Volume 2013 90328. https://doi.org/10.1155/2013/890328

Hematological profile of normal pregnant women in Lagos, Nigeria
Akinbami, A.A., John-olabode, S., Rabiu, K.A., Adewunmi, A.A., Dosunmu, A.O., Adediran, A., Osunkalu, V.O., Osikomaiya, B.I. and Ismail, K.A. 2013. Hematological profile of normal pregnant women in Lagos, Nigeria. International Journal of Women’s Health. 5, pp. 227-232. https://doi.org/10.2147/ijwh.s42110

Prevalence of Asymptomatic Bacteriuria in HIV Infected Patients in a Tertiary Hospital in Lagos, Nigeria
Akinbami, Akinsegun, Bode-Shojobi, Ibidun, John-olabode, Sarah, Oshinaike, Olajumoke, Adediran, Adewumi, Ojelabi, Olaitan, Ismail, Kamal and Osikomaiya, Bodunrin 2013. Prevalence of Asymptomatic Bacteriuria in HIV Infected Patients in a Tertiary Hospital in Lagos, Nigeria. World Journal of AIDS. 3 (2), pp. 105-110. https://doi.org/10.4236/wja.2013.32014

Full blood count pattern of pre-chemotherapy breast cancer patients in Lagos, Nigeria
Akinbami, Akinsegun, Popoola, Abiodun, Adediran, Adewumi, Dosunmu, Adedoyin, Oshinaike, Olajumoke, Adebola, Philip and John-olabode, Sarah 2013. Full blood count pattern of pre-chemotherapy breast cancer patients in Lagos, Nigeria. Caspian Journal of Internal Medicine. 4 (1), pp. 574-579.

New-Onset Seizures in HIV Patients on Antiretroviral Therapy at a Tertiary Centre in South-West, Nigeria
Olajumoke, Oshinaike, Akinsegun, Akinbami, Njideka, Okubadejo, Oluwadamilola, Ojo, Olaitan, Ojelabi, Adedoyin, Dosunmu, Adewumi, Adediran, Akinola, Dada and John-olabode, Sarah 2013. New-Onset Seizures in HIV Patients on Antiretroviral Therapy at a Tertiary Centre in South-West, Nigeria. World Journal of AIDS. 3 (2), pp. 67-70. https://doi.org/10.4236/wja.2013.32009

CD4 Count Pattern and Demographic Distribution of Treatment-Naïve HIV Patients in Lagos, Nigeria
Akinbami, Akinsegun, Dosunmu, Adedoyin, Adediran, Adewumi and John-olabode, Sarah 2012. CD4 Count Pattern and Demographic Distribution of Treatment-Naïve HIV Patients in Lagos, Nigeria. AIDS Research and Treatment. Volume 2012 352753. https://doi.org/10.1155/2012/352753

Permalink - https://westminsterresearch.westminster.ac.uk/item/w6127/prevalence-and-type-of-monoclonal-gammopathy-of-undetermined-significance-in-an-apparently-healthy-nigerian-population-a-cross-sectional-study


Share this

Tweet
Email

Usage statistics

32 total views
12 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.