| Title | Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes |
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| Type | Journal article |
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| Authors | Ancu, O., Naufahu, J., Barclay, R., Watt, P.W. and MacKenzie, R. |
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| Abstract | The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glucose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell function, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally,insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion,acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes. |
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| Keywords | Insulin resistance, Pre-diabetes, β-cell function, Disposition index |
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| Journal | Clinical Diabetes and Research |
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| Journal citation | 5 (1), pp. 55-61 |
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| ISSN | 2642-5009 |
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| Year | 2021 |
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| Publisher | Scholars.Direct |
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| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
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| Digital Object Identifier (DOI) | https://doi.org/10.36959/647/495 |
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| Publication dates |
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| Published | 06 Feb 2021 |
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| Supplemental file | File Access Level Open (open metadata and files) |
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