Kazanis, I. 2005. Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1. PLOS Biology. 3 (6) e186. https://doi.org/10.1371/journal.pbio.0030186
| Title | Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1 |
|---|---|
| Type | Journal article |
| Authors | Kazanis, I. |
| Abstract | Little is known about the molecular mechanisms and intrinsic factors that are responsible for the emergence of neuronal subtype identity. Several transcription factors that are expressed mainly in precursors of the ventral telencephalon have been shown to control neuronal specification, but it has been unclear whether subtype identity is also specified in these precursors, or if this happens in postmitotic neurons, and whether it involves the same or different factors. SOX1, an HMG box transcription factor, is expressed widely in neural precursors along with the two other SOXB1 subfamily members, SOX2 and SOX3, and all three have been implicated in neurogenesis. SOX1 is also uniquely expressed at a high level in the majority of telencephalic neurons that constitute the ventral striatum (VS). These neurons are missing in Sox1-null mutant mice. In the present study, we have addressed the requirement for SOX1 at a cellular level, revealing both the nature and timing of the defect. By generating a novel Sox1-null allele expressing β-galactosidase, we found that the VS precursors and their early neuronal differentiation are unaffected in the absence of SOX1, but the prospective neurons fail to migrate to their appropriate position. Furthermore, the migration of non-Sox1-expressing VS neurons (such as those expressing Pax6) was also affected in the absence of SOX1, suggesting that Sox1-expressing neurons play a role in structuring the area of the VS. To test whether SOX1 is required in postmitotic cells for the emergence of VS neuronal identity, we generated mice in which Sox1 expression was directed to all ventral telencephalic precursors, but to only a very few VS neurons. These mice again lacked most of the VS, indicating that SOX1 expression in precursors is not sufficient for VS development. Conversely, the few neurons in which Sox1 expression was maintained were able to migrate to the VS. In conclusion, Sox1 expression in precursors is not sufficient for VS neuronal identity and migration, but this is accomplished in postmitotic cells, which require the continued presence of SOX1. Our data also suggest that other SOXB1 members showing expression in specific neuronal populations are likely to play continuous roles from the establishment of precursors to their final differentiation. |
| Article number | e186 |
| Journal | PLOS Biology |
| Journal citation | 3 (6) |
| ISSN | 1545-7885 |
| Year | 2005 |
| Publisher | PLoS |
| Digital Object Identifier (DOI) | https://doi.org/10.1371/journal.pbio.0030186 |
| Publication dates | |
| Published | 17 May 2005 |
Reversal of Postnatal Brain Astrocytes and Ependymal Cells towards a Progenitor Phenotype in Culture
Dimitrios Kakogiannis, Michaela Kourla, Dimitrios Dimitrakopoulos and Ilias Kazanis 2024. Reversal of Postnatal Brain Astrocytes and Ependymal Cells towards a Progenitor Phenotype in Culture. Cells. 13 (8) 668. https://doi.org/10.3390/cells13080668
Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration
Theodora Mourtzi, Nasia Antoniou, Christina Dimitriou, Panagiotis Gkaravelas, Georgia Athanasopoulou, Panagiota Nti Kostantzo, Olga Stathi, Efthymia Theodorou, Maria Anesti, Rebecca Matsas, Fevronia Angelatou, Georgia Kouroupi and Ilias Kazanis 2024. Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration. Neural Regeneration Research. 19 (6), pp. 1318-1324. https://doi.org/10.4103/1673-5374.385314
Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going?
Theodora Mourtzi and Ilias Kazanis 2022. Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going? Neural Regeneration Research. 17 (12), pp. 2637-2642. https://doi.org/10.4103/1673-5374.336137
Heterogeneity of quiescent and active neural stem cells in the postnatal brain
Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis and Ilias Kazanis 2022. Heterogeneity of quiescent and active neural stem cells in the postnatal brain. The International Journal of Developmental Biology. 66 (1-2-3), pp. 51-58. https://doi.org/10.1387/ijdb.220010ik
Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays
Maria Anesti, Stavroula Magkafa, Efstathia Prantikou and Ilias Kazanis 2022. Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays. Cells. 11 (11) 1743. https://doi.org/10.3390/cells11111743
Platelets' regulatory role on postnatal brain Neural Stem Cells of the Subependymal Zone
Dimitriou, C., Giachali, M., Lagogiannis, D., Anesti, M., Ghevaert, C., Franklin, R., Rivera, F. and Kazanis, I. 2021. Platelets' regulatory role on postnatal brain Neural Stem Cells of the Subependymal Zone. GLIA. 69 (S1), pp. E501-E502. https://doi.org/10.1002/glia.24036
"Milking": an innovative approach to investigate the properties of postnatal brain neural stem cells and to obtain oligodendrocyte progenitor cells from live experimental rats
Dimitrakopoulos, D., Kakogiannis, D., Franklin, R.J. and Kazanis, I. 2021. "Milking": an innovative approach to investigate the properties of postnatal brain neural stem cells and to obtain oligodendrocyte progenitor cells from live experimental rats. GLIA. 69 (S1), p. E411. https://doi.org/10.1002/glia.24036
Platelets as novel regulators of postnatal brain Neural Stem Cells
Dimitriou, C., Papadimitriou, K., Roussis, K., Guerrero, J., Ghevaert, C., Franklin, R., Symeonidis, A. and Kazanis, I. 2021. Platelets as novel regulators of postnatal brain Neural Stem Cells. GLIA. 67 (S1), pp. E647-E648. https://doi.org/10.1002/glia.23675
Neurogenic and oligodendrogenic cell fate decisions of postnatal brain Neural Stem Cells are differentially dependent on their microenvironment
Anesti, M., Magkafa, S., Prantikou, E. and Kazanis, I. 2021. Neurogenic and oligodendrogenic cell fate decisions of postnatal brain Neural Stem Cells are differentially dependent on their microenvironment. GLIA. 69 (S1), pp. E415-E416. https://doi.org/10.1002/glia.24036
Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats
Freyja McClenahan, Christina Dimitriou, Christos Koutsakis, Dimitrios Dimitrakopoulos, Asterios Arampatzis, Paraskevi Kakouri, Michaela Kourla, Sofia Oikonomou, Evangelia Andreopoulou, Melina Patsonis, Danai-Kassandra Meri, Rana-Tahir Rasool, Robin JM. Franklin and Ilias Kazanis 2021. Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats. Stem Cell Reports. 16 (10), pp. 2534-2547. https://doi.org/10.1016/j.stemcr.2021.08.015
Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20
Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou and Ilias Kazanis 2021. Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20. Stem Cell Research & Therapy. 12 335. https://doi.org/10.1186/s13287-021-02398-3
Cellular senescence in populations of postnatal brain Neural Stem Cells
Anesti, M., Dimitriou, C., Gorgoulis, V. and Kazanis, I. 2019. Cellular senescence in populations of postnatal brain Neural Stem Cells. GLIA. 67 (S1), pp. E503-E504. https://doi.org/10.1002/glia.23675
Milking the postnatal brain neural stem cell niche: a method for isolating endogenous neural stem and progenitor cells from the cerebrospinal fluid
McClenahan, F., Arampatzis, A., Rasool, R., Franklin, R.J.M. and Kazanis, I. 2017. Milking the postnatal brain neural stem cell niche: a method for isolating endogenous neural stem and progenitor cells from the cerebrospinal fluid. GLIA. 65 (S1), pp. E538-E539. https://doi.org/10.1002/glia.23157
The extracellular matrix glycoprotein Tenascin-C regulates the behavior of cortical neural stem cells during the neuroepithelial to radial glial transition
Patsoni, M., Kazanis, I., Ffrench-Constant, C., Faissner, A. and May, M. 2017. The extracellular matrix glycoprotein Tenascin-C regulates the behavior of cortical neural stem cells during the neuroepithelial to radial glial transition. GLIA. 65 (S1), pp. E408-E409. https://doi.org/10.1002/glia.23157
Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice
Kazanis, Ilias, Evans, Kimberley A., Andreopoulou, Evangelia, Dimitriou, Christina, Koutsakis, Christos, Karadottir, Ragnhildur Thora and Franklin, Robin J. M. 2017. Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice. Stem Cell Reports. 8 (3), pp. P685-700. https://doi.org/10.1016/j.stemcr.2017.01.007
Being a Neural Stem Cell: A Matter of Character But Defined by the Microenvironment
Evangelia Andreopoulou, Asterios Arampatzis, Melina Patsoni and Ilias Kazanis 2017. Being a Neural Stem Cell: A Matter of Character But Defined by the Microenvironment. in: Birbrair, A. (ed.) Stem Cell Microenvironments and Beyond Springer. pp. 81-118
Oligodendrocyte progenitor cells: the ever mitotic cells of the CNS
Neumann, B. and Kazanis, I. 2016. Oligodendrocyte progenitor cells: the ever mitotic cells of the CNS. Frontiers in Bioscience-Scholar. 8 (1), pp. 29-43. https://doi.org/10.2741/s444
How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System.
Koutsakis, C. and Kazanis, I. 2016. How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System. Frontiers in Cellular Neuroscience. 10 35. https://doi.org/10.3389/fncel.2016.00035
CNS lesion-induced accumulation of platelets promotes survival of adult SVZ-derived neural stem / progenitor cells
Rivera, F., Kazanis, I., Feichtner, M., Lange, S., Rotheneichner, P., Hainzl, S., Oeller, M., Schallmoser, K., Rohde, E., Reitsamer, H. A., Couillard-Despres, S., Bauer, H. -C., Franklin, R. J. M. and Aigner, L. 2015. CNS lesion-induced accumulation of platelets promotes survival of adult SVZ-derived neural stem / progenitor cells. GLIA. 63 (S1), p. E403. https://doi.org/10.1002/glia.22870
Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.
Kazanis, I., Feichtner, M., Lange, S., Rotheneichner, P., Hainzl, S., Öller, M., Schallmoser, K., Rohde, E., Reitsamer, H.A., Couillard-Despres, S., Bauer, H.C., Franklin, R.J., Aigner, L. and Rivera, F.J. 2015. Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells. Experimental Neurology. 269, pp. 75-89. https://doi.org/10.1016/j.expneurol.2015.03.018
Beyond Clotting: A Role of Platelets in CNS Repair?
Rivera, F.J., Kazanis, I., Ghevaert, C. and Aigner, L. 2015. Beyond Clotting: A Role of Platelets in CNS Repair? Frontiers in Cellular Neuroscience. 9 511. https://doi.org/10.3389/fncel.2015.00511
Disc1 variation leads to specific alterations in adult neurogenesis
Chandran, J.S., Kazanis, I., Clapcote, S.J., Ogawa, F., Millar, J.K., Porteous, D.J. and Ffrench-Constant, C. 2014. Disc1 variation leads to specific alterations in adult neurogenesis. PLoS ONE. https://doi.org/10.1371/journal.pone.0108088
Adult Neural Stem Cells Generate Waves of Oligodenrocyte Progenitor Cells That Populate Transiently the Corpus Callosum but Do Not Contribute to Its Pool of Oligodendrocytes
Kazanis, I. and Franklin, R. 2013. Adult Neural Stem Cells Generate Waves of Oligodenrocyte Progenitor Cells That Populate Transiently the Corpus Callosum but Do Not Contribute to Its Pool of Oligodendrocytes. GLIA. 61 (S1), p. S148. https://doi.org/10.1002/glia.22530
Niche derived oligodendrocyte progenitors: A source of rejuvenation or complementation for local oligodendrogenesis?
Agathou, S., Káradóttir, R.T. and Kazanis, I. 2013. Niche derived oligodendrocyte progenitors: A source of rejuvenation or complementation for local oligodendrogenesis? Frontiers in Cellular Neuroscience. 7. https://doi.org/10.3389/fncel.2013.00188
Reforming the Greek health system: A role for non-medical, clinical bioscientists
Kazanis, I. 2013. Reforming the Greek health system: A role for non-medical, clinical bioscientists. Health Policy. 109 (1), pp. 46-51. https://doi.org/10.1016/j.healthpol.2012.03.020
The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche
Kazanis, I., Gorenkova, N., Zhao, J.-W., Franklin, R.J.M., Modo, M. and ffrench-Constant, C. 2013. The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche. Experimental Neurology. 248, pp. 387-397. https://doi.org/10.1016/j.expneurol.2013.06.025
Neurogenesis in the Adult Mammalian Brain: How Much Do We Need, How Much Do We Have?
Kazanis, I. 2013. Neurogenesis in the Adult Mammalian Brain: How Much Do We Need, How Much Do We Have? in: Belzung, C. and Wigmore, P. (ed.) Neurogenesis and Neural Plasticity Springer. pp. 3-29
Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology
Kazanis, I. 2012. Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology. The Neuroscientist. 18 (1), pp. 15-27. https://doi.org/10.1177/1073858410390379
Can adult neural stem cells create New Brains? plasticity in the adult mammalian neurogenic niches: Realities and expectations in the Era of regenerative biology
Kazanis, I. 2011. Can adult neural stem cells create New Brains? plasticity in the adult mammalian neurogenic niches: Realities and expectations in the Era of regenerative biology. The Neuroscientist. 18 (1), pp. 15-27. https://doi.org/10.1177/1073858410390379
The Number of Stem Cells in the Subependymal Zone of the Adult Rodent Brain is Correlated with the Number of Ependymal Cells and Not with the Volume of the Niche
Kazanis, I. and ffrench-Constant, C. 2011. The Number of Stem Cells in the Subependymal Zone of the Adult Rodent Brain is Correlated with the Number of Ependymal Cells and Not with the Volume of the Niche. Stem Cells and Development. 21 (7). https://doi.org/10.1089/scd.2011.0130
Extracellular matrix and the neural stem cell niche
Kazanis, I. 2011. Extracellular matrix and the neural stem cell niche. Developmental Neurobiology. 71 (11), pp. 1006-1017. https://doi.org/10.1002/dneu.20970
Adhesion molecules in the stem cell niche - More than just staying in shape?
Marthiens, V., Kazanis, I., Moss, L., Long, K. and Ffrench-Constant, C. 2010. Adhesion molecules in the stem cell niche - More than just staying in shape? Journal of Cell Science. 123 (10), pp. 1613-1622. https://doi.org/10.1242/jcs.054312
Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals
Kazanis, I., Lathia, J.D., Vadakkan, T.J., Raborn, E., Wan, R., Mughal, M.R., Eckley, D.M., Sasaki, T., Patton, B., Mattson, M.P., Hirschi, K.K., Dickinson, M.E. and ffrench-Constant, C. 2010. Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. Journal of Neuroscience. 30 (29), pp. 9771-9781. https://doi.org/10.1523/jneurosci.0700-10.2010
Activated Adult Neural Stem Cells Generate Distinct Laminin/Integrin Interactions During Regeneration of the Subependymal Zone Neurogenic Niche
Kazanis, I, Lathia, J.D., Vadakkan, T.J., Mattson, M.P., Dickinon, M.E. and Ffrench-Constant, C. 2009. Activated Adult Neural Stem Cells Generate Distinct Laminin/Integrin Interactions During Regeneration of the Subependymal Zone Neurogenic Niche. GLIA. 57 (S13), p. S76. https://doi.org/10.1002/glia.20915
The Extracellular Matrix Glycoprotein Tenascin-C Controls the Activity of Directly Neurogenic Progenitors in the Ventricular Zone of the Mouse Embryonic Forebrain
Kazanis, I and Ffrench-Constant, C. 2009. The Extracellular Matrix Glycoprotein Tenascin-C Controls the Activity of Directly Neurogenic Progenitors in the Ventricular Zone of the Mouse Embryonic Forebrain. GLIA. 57 (S13), pp. S83-S84. https://doi.org/10.1002/glia.20915
The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed
Kazanis, I. 2009. The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed. Brain. 132 (11), p. 2909–2921. https://doi.org/10.1093/brain/awp237
The neural stem cell microenvironment
Kazanis, I., Lathia, J., Moss, L. and ffrench-Constant, C. 2008. The neural stem cell microenvironment. in: StemBook Harvard Stem Cell Institute.
A study of the adult sub-ependymal zone and of its regeneration following AraC treatment, in the Tenascin C null mice
Kazanis, Ilias, Belhadi, Aisha, Gossage, Sam, ffrench-Constant, Charles and Kazanis, Ilias 2007. A study of the adult sub-ependymal zone and of its regeneration following AraC treatment, in the Tenascin C null mice. Neuron Glia Biology. 2 (S1), p. S51.
The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C
Kazanis, I., Belhadi, A., Faissner, A. and Ffrench-Constant, C. 2007. The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C. Journal of Neuroscience. 27 (51), pp. 13991-13996. https://doi.org/10.1523/jneurosci.3279-07.2007
Dual function of Sox1 in telencephalic progenitor cells
Kazanis, I. 2007. Dual function of Sox1 in telencephalic progenitor cells. Developmental Biology. 310 (1), pp. 85-98. https://doi.org/10.1016/j.ydbio.2007.07.026
Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1
Ekonomou, A., Kazanis, I., Malas, S., Wood, H., Alifragis, P., Denaxa, M., Karagogeos, D., Constanti, A., Lovell-Badge, R. and Episkopou, V. 2005. Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLOS Biology. 3 (6) e186. https://doi.org/10.1371/journal.pbio.0030186
CNS injury research; reviewing the last decade: Methodological errors and a proposal for a new strategy
Kazanis, I. 2005. CNS injury research; reviewing the last decade: Methodological errors and a proposal for a new strategy. Brain Research Reviews. 50 (2), pp. 377-386. https://doi.org/10.1016/j.brainresrev.2005.09.003
Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration
Kazanis, I., Giannakopoulou, M., Philippidis, H. and Stylianopoulou, F. 2004. Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration. Experimental Neurology. 186 (2), pp. 221-234. https://doi.org/10.1016/j.expneurol.2003.12.004
Study of tissue alterations in traumatized regions of the rat CNS
Kazanis, I. 2003. Study of tissue alterations in traumatized regions of the rat CNS. PhD thesis National and Kapodistrian University of Athens School of Medicine
Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex
Mantelas, A., Stamatakis, A., Kazanis, I., Philippidis, H. and Stylianopoulou, F. 2003. Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex. Developmental Brain Research. 145 (2), pp. 185-195. https://doi.org/10.1016/j.devbrainres.2003.08.001
Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats
Kazanis, I. 2003. Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats. Brain Research. 991 (1-2), pp. 34-45. https://doi.org/10.1016/s0006-8993(03)03525-x
Genetic detection of bladder cancer by microsatellite analysis of p16, RB1 and p53 tumor suppressor genes
Sourvinos, G., Kazanis, I., Delakas, D., Cranidis, A. and Spandidos, D.A. 2001. Genetic detection of bladder cancer by microsatellite analysis of p16, RB1 and p53 tumor suppressor genes. Journal of Urology. 165 (1), pp. 249-252. https://doi.org/10.1097/00005392-200101000-00073
In utero radiation-induced changes in growth factor levels in the developing rat brain
Benekou, A., Bolaris, S., Kazanis, I., Bozas, E., Philippidis, H. and Stylianopoulou, F. 2001. In utero radiation-induced changes in growth factor levels in the developing rat brain. International Journal of Radiation Biology. 77 (1), pp. 83-93. https://doi.org/10.1080/095530001453140
Molecular mechanisms involved in the response of brain tissue to trauma molecular mechanisms involved in the response of brain tissue to trauma
Kazanis, E., Filippidou, H., Stylianopoulou, F. and Kazanis, I. 2001. Molecular mechanisms involved in the response of brain tissue to trauma molecular mechanisms involved in the response of brain tissue to trauma. Archives of Hellenic Medicine. 18 (4), pp. 363-374.
NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide
Giannakopoulou, M., Mansour, M., Kazanis, E., Bozas, E., Philpipidis, H., Stylianopoulou, F. and Kazanis, I. 2000. NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide. Neuropathology and Applied Neurobiology. 26 (6), pp. 513-521. https://doi.org/10.1046/j.0305-1846.2000.00286.x
Permalink - https://westminsterresearch.westminster.ac.uk/item/w7vwz/neuronal-migration-and-ventral-subtype-identity-in-the-telencephalon-depend-on-sox1