Multiscale, multidomain analysis of microvascular flow dynamics

Chipperfield, A.J., Thanaj, M. and Clough, G.F. 2020. Multiscale, multidomain analysis of microvascular flow dynamics. Experimental Physiology. 105 (9), pp. 1452-1458. https://doi.org/10.1113/ep087874

TitleMultiscale, multidomain analysis of microvascular flow dynamics
TypeJournal article
AuthorsChipperfield, A.J., Thanaj, M. and Clough, G.F.
Abstract

To date, time- and frequency-domain metrics of signals acquired through laser Doppler fluximetry have been unable to provide consistent and robust measures of the changes that occur in the microcirculation in healthy individuals at rest or in response to a provocation, or in patient cohorts. Recent studies have shown that in many disease states, such as metabolic and cardiovascular disease, there appears to be a reduction in the adaptive capabilities of the microvascular network and a consequent reduction in physiological information content. Here, we introduce non-linear measures for assessing the information content of fluximetry signals and demonstrate how they can yield deeper understanding of network behaviour. In addition, we show how these methods may be adapted to accommodate the multiple time scales modulating blood flow and how they can be used in combination with time- and frequency-domain metrics to discriminate more effectively between the different mechanistic influences on network properties.

JournalExperimental Physiology
Journal citation105 (9), pp. 1452-1458
ISSN1469-445X
0958-0670
Year2020
PublisherThe Physiological Society
Wiley
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1113/ep087874
Web address (URL)https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/EP087874
Publication dates
Published01 Sep 2020

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