TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

In sepsis hydrogen peroxide release accompanies neutrophil chemotaxis to organs, artesunate prevents this neutrophil-mediated organ infiltration, cytokine storm and NET release
Morad, H. 2024. In sepsis hydrogen peroxide release accompanies neutrophil chemotaxis to organs, artesunate prevents this neutrophil-mediated organ infiltration, cytokine storm and NET release. International Conference on Vaccines and Immunology . Paris, France 17 - 18 Oct 2024 Scientific Collegium.

Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Morad, H.O.J., Luqman, S., Garcia Pinto, L., Cunningham, K., Vilar, B., Clayton, G., Shankar-Hari, M. and McNaughton, P.A. 2022. Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release. Scientific Reports. 2022 (12) 11078. https://doi.org/10.1038/s41598-022-15214-6

Repurposing the antimalarial compound artemisinin as a novel therapy for inflammatory conditions
Morad, H. 2022. Repurposing the antimalarial compound artemisinin as a novel therapy for inflammatory conditions. Drug Repurposing II. Woburn House, London, UK 10 - 11 May 2022 The Biochemical Society.

Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Morad, H.O.J., Luqman, S., Pinto, L.G., Cunningham, K.P., Vilar, B., Clayton, G., Shankar-Hari, M. and McNaughton, P.A. 2022. Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release. Scientific Reports. 12 (1), pp. 1-18. https://doi.org/10.1038/s41598-022-15214-6

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug conjugates (ADcs)
Hoffmann, R.M., Mele, S., Cheung, A., Larcombe-Young, D., Bucaite, G., Sachouli, E., Zlatareva, I., Morad, H., Marlow, R., McDonnell, J.M., Figini, M., Lacy, K.E., Tutt, A.J.N., Spicer, J.F., Thurston, D.E., Karagiannis, S.N. and Crescioli, S. 2020. Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug conjugates (ADcs). Scientific Reports. 10 (1), pp. 1-11. https://doi.org/10.1038/s41598-020-65860-x

O30 Natural compounds affecting neutrophil migration
Hassan Morad, Suaib Luqman and Peter McNaughton 2017. O30 Natural compounds affecting neutrophil migration. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2017.06.095

O30 Natural compounds affecting neutrophil migration
Morad, H., Luqman, S. and McNaughton, P. 2017. O30 Natural compounds affecting neutrophil migration. Biochemical Pharmacology. 139 (1), p. 119. https://doi.org/10.1016/j.bcp.2017.06.095

Time-course analysis of C3a and C5a quantifies the coupling between the upper and terminal Complement pathways in vitro
Morad, H. 2014. Time-course analysis of C3a and C5a quantifies the coupling between the upper and terminal Complement pathways in vitro. Royal Society of Medicine, Clinical Immunology and Allergy Conference. University of Cambridge Sep - Oct 2014 Royal Society of Medicine.