Biomedical Sciences

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ncreased expression of microRNA-146a/b negatively regulates IL-1b induced cytokine release from airway epithelial cells

Conference paper

Perry, M.M., Moschos, S.A., Williams, A.E. and Lindsay, M.A. 2007. ncreased expression of microRNA-146a/b negatively regulates IL-1b induced cytokine release from airway epithelial cells. Proceedings of the American Thoracic Society 2007 International Conference. San Francisco 18 - 23 May 2007 pp. A239

Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids

Article

Moschos, S.A., Williams, A.E., Perry, M.M., Birrell, M.A., Belvisi, M.G. and Lindsay, M.A. 2007. Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics. 8 (1), p. 240. https://doi.org/10.1186/1471-2164-8-240

Expression profiling implicates microRNA expression in the resolution of the inflammatory response in vivo

Conference paper

Moschos, S.A., Perry, M.M., Williams, A.E. and Lindsay, M.A. 2007. Expression profiling implicates microRNA expression in the resolution of the inflammatory response in vivo. Proceedings of the American Thoracic Society 2007 International Conference. San Francisco 18 - 23 May 2007 pp. A239

Lung delivery studies using siRNA conjugated to TAT(48−60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity

Article

Moschos, S.A., Jones, S.W., Perry, M.M., Williams, A.E., Erjefalt, J.S., Turner, J.J., Barnes, P.J., Sproat, B.S., Gait, M.J. and Lindsay, M.A. 2007. Lung delivery studies using siRNA conjugated to TAT(48−60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjugate Chemistry. 18 (5), pp. 1450-1459. https://doi.org/10.1021/bc070077d

The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner

Article

McArthur, S., McHale, E. and Gillies, G.E. 2007. The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner. Neuropsychopharmacology. 32 (7), pp. 1462-1476. https://doi.org/10.1038/sj.npp.1301277

Six adult onset TTP patients with several ADAMTS13 polymorphisms and a missense mutation (R1060W) that exhibits defective secretion in vitro

Conference paper

Camilleri, R., Cohen, H., Mackie, I.J., Scully, M., Starke, R.D., Crawley, J.T.B., Lane, D.A. and Machin, S.J. 2007. Six adult onset TTP patients with several ADAMTS13 polymorphisms and a missense mutation (R1060W) that exhibits defective secretion in vitro. XXIst Congress of the International Society on Thrombosis and Haemostasis. Geneva, Switzerland

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery

Journal article

Shah, C.M., Bell, S.E., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2007. Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery. Nitric Oxide. 16 (1), pp. 135-142. https://doi.org/10.1016/j.niox.2006.08.001

The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease

Journal article

Abuirmeileh, A., Lever, R., Kingsbury, A.E., Lees, A.J., Locke, I.C., Knight, R.A., Chowdrey, H.S., Biggs, C.S. and Whitton, P.S. 2007. The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience. 26 (2), pp. 417-423. https://doi.org/10.1111/j.1460-9568.2007.05653.x

Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells

Article

Schwarz, N., Renshaw, D., Kapas, S. and Hinson, J.P. 2006. Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells. Journal of Endocrinology. 190 (2), pp. 505-514. https://doi.org/10.1677/joe.1.06806

In vitro and in vivo delivery studies of siRNA-peptide conjugates

Article

Turner, J.J., Fabani, M.M., Jones, S.W., Moschos, S.A., Perry, M.M., Lindsay, M.A. and Gait, M.J. 2006. In vitro and in vivo delivery studies of siRNA-peptide conjugates. Journal of RNAi and Gene Silencing. 2 (2), pp. 171-172.

Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality

Article

Kosti, O., Raven, P.W., Renshaw, D. and Hinson, J.P. 2006. Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality. Journal of Endocrinology. 189 (2), pp. 211-218. https://doi.org/10.1677/joe.1.06638

In vitro investigations of the effects of orlistat on the human faecal microbiota

Conference poster

Hoyles, L., Daggy, B.P., Gibson, G.R. and McCartney, A.L. 2006. In vitro investigations of the effects of orlistat on the human faecal microbiota. SGM Annual Meeting. University of Warwick, UK 03 Apr 2006

Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors

Article

Murray, J.F., Hahn, J.D., Kennedy, A.R., Small, C.J., Bloom, S.R., Haskell-Luevano, C., Coen, C.W. and Wilson, C.A. 2006. Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. Journal of Neuroendocrinology. 18 (3), pp. 157-167. https://doi.org/10.1111/j.1365-2826.2005.01397.x

Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A

Article

Moschos, S.A. and Bramwell, V.W. 2006. Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A. Vaccine. 24 (8), pp. 1081-1086. https://doi.org/10.1016/j.vaccine.2005.09.007

Redox chemistry at the platelet surface

Conference paper

Nur, M., Williamson, P., Bell, A. and Gordge, M.P. 2006. Redox chemistry at the platelet surface. 8th UK Platelet Conference. Reading, UK 07-08 Sep 2006

Interactions between amyloid-ß and enzymes

Book chapter

Milton, N.G.N. 2006. Interactions between amyloid-ß and enzymes. in: Harris, J.R., Graham, J. and Rickwood, D. (ed.) Cell biology protocols Chichester Wiley. pp. 359-363

Anti-sense peptides

Book chapter

Milton, N.G.N. 2006. Anti-sense peptides. in: Harris, J.R., Graham, J. and Rickwood, D. (ed.) Cell biology protocols Chichester Wiley. pp. 353-358

Amyloid-ß phosphorylation

Book chapter

Milton, N.G.N. 2006. Amyloid-ß phosphorylation. in: Harris, J.R., Graham, J. and Rickwood, D. (ed.) Cell biology protocols Chichester Wiley. pp. 364-368

Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats

Article

McArthur, S., Siddique, Z.L., Christian, H.C., Capone, G., Theogaraj, E., John, C.D., Smith, S.F., Morris, J.F., Buckingham, J.C. and Gillies, G.E. 2006. Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats. Endocrinology. 147 (4), pp. 1904-1915. https://doi.org/10.1210/en.2005-1496

The ADAMTS13 missense mutant R1060W, found in six patients with adult onset TTP, exhibits a secretion defect in vitro

Conference paper

Camilleri, R., Mackie, I.J., Scully, M., Starke, R.D., Crawley, J.T.B., Lane, D.A., Machin, S.J. and Cohen, H. 2006. The ADAMTS13 missense mutant R1060W, found in six patients with adult onset TTP, exhibits a secretion defect in vitro. British society for haemostasis and thrombosis (BSHT) scientific meeting. Jersey, UK

Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary

Article

Lea, R.G., Andrade, L.P., Rae, M.T., Hannah, L.T., Kyle, C.E., Murray, J.F., Rhind, S.M. and Miller, D.W. 2006. Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary. Reproduction. 131, pp. 113-124. https://doi.org/10.1530/rep.1.00844

Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure

Article

McArthur, S., McHale, E., Dalley, J.W., Buckingham, J.C. and Gillies, G.E. 2005. Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure. Journal of Neuroendocrinology. 17 (8), pp. 475-482. https://doi.org/10.1111/j.1365-2826.2005.01331.x

The impact of long-chain n-3 polyunsaturated fatty acids on human health

Article

Ruxton, C.H.S., Calder, P.C., Reed, S.C. and Simpson, J.A. 2005. The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutrition Research Reviews. 18 (1), pp. 113-129. https://doi.org/10.1079/NRR200497

Megakaryocyte apoptosis: sorting out the signals

Article

Gordge, M.P. 2005. Megakaryocyte apoptosis: sorting out the signals. British Journal of Pharmacology. 145 (3), pp. 271-273. https://doi.org/10.1038/sj.bjp.0706202

Developmental indices of nutritionally induced placental growth restriction in the adolescent sheep

Article

Lea, R.G., Hannah, L.T., Redmer, D.A., Aitken, R.P., Milne, J.S., Fowler, P.A., Murray, J.F. and Wallace, J.M. 2005. Developmental indices of nutritionally induced placental growth restriction in the adolescent sheep. Pediatric Research. 57 (4), pp. 599-604. https://doi.org/10.1203/01.PDR.0000155949.08547.66

Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells

Article

Wright, E., Bain, M., Teague, L., Murphy, J. and Sinclair, J. 2005. Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells. Journal of General Virology. 86 (3), pp. 535-544. https://doi.org/10.1099/vir.0.80352-0

Phosphorylated Amyloid-ß 1-43 protein and its use in the treatment of Alzheimer's disease

Patent

Milton, N.G.N. 2005. Phosphorylated Amyloid-ß 1-43 protein and its use in the treatment of Alzheimer's disease.

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes

Conference paper

Shah, C.M., Walters, S.E., Locke, I.C., Chowdrey, H.S. and Gordge, M.P. 2005. Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes. Ireland-UK Platelet Conference 2005. Dublin, Ireland 04-06 Sep 2005

Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation

Article

Moschos, S.A., Bramwell, V.W., Somavarapu, S. and Alpar, H.O. 2005. Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation. Vaccine. 23 (16), pp. 1923-1930. https://doi.org/10.1016/j.vaccine.2004.10.016

Phosphorylated amyloid-ß: the toxic intermediate in Alzheimer's disease neurodegeneration

Article

Milton, N.G.N. 2005. Phosphorylated amyloid-ß: the toxic intermediate in Alzheimer's disease neurodegeneration. Subcellular Biochemistry. 38, pp. 381-402.

A neurofuzzy methodology for the diagnosis of wireless-capsule endoscopic images

Book chapter

Kodogiannis, V. and Chowdrey, H.S. 2005. A neurofuzzy methodology for the diagnosis of wireless-capsule endoscopic images. in: Duch, W., Kacprzyk, J., Oja, E. and Zadrozny, S. (ed.) Artificial Neural Networks: Biological Inspirations ICANN 2005: 15th International Conference Warsaw, Poland, September 11-15, 2005 Proceedings, Part I Berlin, Germany Springer.

A novel mutation in the ADAMTS13 gene of patients with adult onset TTP

Conference paper

Camilleri, R., Mackie, I.J., Scully, M., Machin, S.J. and Cohen, H. 2005. A novel mutation in the ADAMTS13 gene of patients with adult onset TTP. British society for haemostasis and thrombosis (BSHT) scientific meeting. Chester, UK

A genetic basis for adult onset TTP?

Conference paper

Camilleri, R., Mackie, I.J., Scully, M., Machin, S.J. and Cohen, H. 2005. A genetic basis for adult onset TTP? American society of haematology 47th annual meeting. Atlanta, Georgia, USA.

ADAMTS13 gene mutations and polymorphisms in acquired thrombotic thrombocytopenic purpura (TTP) patients

Conference paper

Camilleri, R., Mackie, I.J., Scully, M., Machin, S.J. and Cohen, H. 2005. ADAMTS13 gene mutations and polymorphisms in acquired thrombotic thrombocytopenic purpura (TTP) patients. XXth Congress of the international society on thrombosis and haemostasis. Sydney, Australia

No association between pulmonary embolism or deep vein thrombosis and the –455G/A β-fibrinogen gene polymorphism

Article

Camilleri, R. and Cohen, H. 2005. No association between pulmonary embolism or deep vein thrombosis and the –455G/A β-fibrinogen gene polymorphism. Blood Coagulation & Fibrinolysis. 16 (3), pp. 193-198.

Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat

Conference paper

Biggs, C.S., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat. 18th National Meeting of the British Neuroscience Association. Brighton, UK 03-06 Apr 2005

Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model

Article

Biggs, C.S., Abuirmeileh, A., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society. 3 (4).

Intracorporeal videoprobe (IVP)

Book chapter

Arena, A., Boulougoura, M., Chowdrey, H.S., Dario, P., Harendt, C., Irion, K.M., Kodogiannis, V., Lenaerts, B., Menciassi, A., Puers, R., Scherjon, C. and Turgis, D. 2005. Intracorporeal videoprobe (IVP). in: Bos, L., Laxminarayan, S. and Marsh, A.J. (ed.) Medical and Care Compunetics Amsterdam, Netherlands ; Oxford, UK IOS Press.

Leptin expression in the fetus and placenta during mouse pregnancy

Article

Malik, N.M., Carter, N.D., Wilson, C.A., Scaramuzzi, R.J., Stock, M.J. and Murray, J.F. 2005. Leptin expression in the fetus and placenta during mouse pregnancy. Placenta. 26 (1), pp. 47-52. https://doi.org/10.1016/j.placenta.2004.03.009

Therapeutic approaches to raising plasma HDL-cholesterol levels

Article

Thompson, M., Reed, S.C. and Cockerill, G. 2004. Therapeutic approaches to raising plasma HDL-cholesterol levels. Nature Clinical Practice Cardiovascular Medicine. 1 (2), pp. 84-89. https://doi.org/10.1038/ncpcardio0044


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