Pathobiology and Extracellular Vesicle Research Group

Lange, S., Gíslason, S., Needham, S.R., Davis, B.M., Kraev, I., Guls, H.D., Georgsdóttir, S.D., Kristmundsson, A and Halldórsson, H.P. 2026. Extracellular vesicle signatures are modified in haemolymph of atlantic rock crab (Cancer irroratus) infected with shell disease – a Study from Icelandic waters. Comparative Immunology Reports. 11 200299. https://doi.org/10.1016/j.cirep.2026.200299

Ahmed, B.Y., Lange, S., Warda, M., Shadidizaji, A. and Uysal Onganer, P. 2026. Oleuropein Attenuates 6-Hydroxydopamine-Induced Cytotoxicity Through Redox Regulation in Differentiated Dopaminergic Neurons: Potential Involvement of RET-Associated Signalling. International Journal of Molecular Sciences. 27 (13), p. 5892 5892. https://doi.org/10.3390/ijms27135892

Ahmed, D., Getting, S., Ashioti, M. and Lange, S. 2026. Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury—Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen–Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro. International Journal of Molecular Sciences. 27 (11) 5118. https://doi.org/10.3390/ijms27115118

Ahmed, D., Getting, S.J., Ashioti, M. and Lange, S. 2026. Preprint: Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury—Pro-Regenerative Effects of Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) In Vitro. Preprints.org. https://doi.org/10.20944/preprints202604.1848.v1

Thiyagarajan, D.B., Mikkelborg, M.K., Kraev, I., Dalmo, R.A. and Lange, S. 2026. Characterization of extracellular vesicles from primary skin epithelial cells and cell lines from Atlantic salmon. Developmental and Comparative Immunology. 176 105555. https://doi.org/10.1016/j.dci.2026.105555

Li, R., Needham, S.R., Kraev, I., Hristova, M. and Lange, S. 2025. Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult—findings from a neonatal mouse model. Frontiers in Medical Technology. 7 1715676. https://doi.org/10.3389/fmedt.2025.1715676

Needham, S.R., Davis, B.M., Uysal Onganer, P., Rolfe, D.J., Hristova, M., Kraev, I., Inal, J.M. and Lange, S. 2025. Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy. Journal of Biophotonics. 2025 e202500483. https://doi.org/10.1002/jbio.202500483

Mannaperuma, D., Stratton, D., Lange, S. and Inal, J.M. 2025. Extracellular Vesicles from the Myocyte Secretome Contribute In Vitro to Creating an Unfavourable Environment for Migrating Lung Carcinoma Cells. Biology. 14 (11), p. 1578 1578. https://doi.org/10.3390/biology14111578

Lange, S., Bernstein, D.E., Dimov, N., Puttaswamy, S., Jonhston, I., Kraev, I., Needham, S.R., Vasdev, N. and Inal, J.M. 2025. Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer Patients. International Journal of Molecular Sciences. 26 (14) 6895. https://doi.org/10.3390/ijms26146895

Dalessio, S., Kraev, I., Magnadóttir, B. and Lange, S. 2025. Exploring the Potential of Extracellular Vesicles from Atlantic Cod (Gadus morhua L.) Serum and Mucus for Wound Healing In Vitro. Biology. 14 (7), p. 870 14070870. https://doi.org/10.3390/biology14070870

Vaughan, O.R., Maksym, K., Hillman, S., Spencer, R.N., Hristova, M., David, A.L. and Lange, S. 2025. Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction. International Journal of Molecular Sciences. 26 (9), p. 4247 4247. https://doi.org/10.3390/ijms26094247

Sigrun Lange and Jameel M. Inal 2024. Animal Models of Human Disease 2.0. International Journal of Molecular Sciences. 25 (24) 13743. https://doi.org/10.3390/ijms252413743

Ansa-Addo, E.A., Pathak, P., McCrossan, M.V., Volpato Rossi, I., Abdullahi, M., Stratton, D., Lange, S., Ramirez, M.I. and Inal, J.M. 2024. Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1. Journal of Extracellular Vesicles. 13 e70014. https://doi.org/10.1002/jev2.70014

Romani, A., Antonietti, A., Bella, D., Budd, J., Giacalone, E., Kurban, K., Sáray, S., Abdellah, M., Arnaudon, A., Boci, E., Colangelo, C., Courcol, J-D., Delemontex, T., Ecker, A., Falck, J., Favreau, C., Gevaert, M., Hernando, J.B., Herttuainen, J., Ivaska, G., Kanari. L., Kaufmann, A-K., King, J.G., Kumbhar, P., Lange, S., Lu, H., Lupascu, C.A., Migliore, R., Petitjean, F., Planas, J., Rai, P., Ramaswamy, S., Reimann, M., Riquelme, J.L., Guerrero, N.R., Shi, Y., Sood, V., Sy, M.F., Van Geit, W., Vanherp, L., Freund, T.F., Mercer, A., Muller, E., Schürmann, F., Thomson, A.M., Migliore, M., Káli, S. and Markram, H. 2024. Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region. PLOS Biology. 22 (11) e3002861. https://doi.org/10.1371/journal.pbio.3002861

Ferreira, A.M., Silva-Álvarez, V., Kraev, I., Uysal Onganer, P. and Lange, S. 2024. Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge. Fish and Shellfish Immunology. 154 (8), p. 109974 109974. https://doi.org/10.1016/j.fsi.2024.109974

Mercer, A., Sancandi, M., Maclatchy, A. and Lange, S. 2024. Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model. International Journal of Molecular Sciences. 25 (20) 11168. https://doi.org/10.3390/ijms252011168

Lange, S., Inal, J.M., Kraev, I., Dart, D. and Uysal Onganer, P. 2024. Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties. Biology. 13 (9), p. 734 13090734. https://doi.org/10.3390/biology13090734

Mercer, A., Sancandi, M., Maclatchy, A. and Lange, S. 2024. Preprint: The Brain Region Specific Citrullinome and PAD 1-6 Isozyme Detection in a Pre-motor Parkinson’s Disease Rat Model. Preprints.org. https://doi.org/10.20944/preprints202406.2001.v1

Joshua A. Welsh, Deborah Goberdhan, Lorraine O'Driscoll, Edit Buzás, Cherie Blenkiron, Bussolati B, Joseph Whitley, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan M Falcon-Perez, Qing‐Ling Fu, Andrew Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana Claudia Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic‐Talisman, Nicole A. Kruh‐Garcia, Vroniqa Ku'ulei‐Lyn Faustino, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena Martens-Uzunova, Rachel R. Mizenko, Lauren Newman, Andrea Ridolfi, Eva Rohde, Lange, S. and Dina Ahmed 2024. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles. 13 (2) e12404. https://doi.org/10.1002/jev2.12404

Coates, C., Rowley, A. and Lange, S. 2023. Immunopathology of Hematodinium sp. infection of decapod crustaceans. Developmental and Comparative Immunology. 148 104936. https://doi.org/10.1016/j.dci.2023.104936

Lange, S. and Inal, J.M. 2023. Animal Models of Human Disease. International Journal of Molecular Sciences. 24 (21), p. 15821 ijms242115821. https://doi.org/10.3390/ijms242115821

Jorfi, S., Ansa-Addo, E.A., Mariniello, K., Warde, P., Bin Senian, A.A., Stratton, D., Bax, B.E., Levene, M., Lange, S. and Inal, J.M. 2023. A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release. Journal of General Virology. 104 (9) 001884. https://doi.org/10.1099/jgv.0.001884

Mitra, S., Harvey-Jones, K., Kraev, I., Verma, V., Meehan, C., Mintoft, A., Norris, G., Campbell, E., Tucker, K., Robertson, N.J., Hristova, M. and Lange, S. 2023. The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures. International Journal of Molecular Sciences. 24 (14) 11529. https://doi.org/10.3390/ijms241411529