A drug repurposing screen for whipworms informed by comparative genomics. Coghlan A., Partridge, F.A., Duque-Correa M.A., Rinaldi, G., Clare, S., Seymour, L., Brandt, C., Mkandawire, T.T., McCarthy, C., Holroyd, N., Nick, M., Brown, A.E. and Berriman, M. 2023. A drug repurposing screen for whipworms informed by comparative genomics. PLoS Neglected Tropical Diseases. 17 (9) e0011205. https://doi.org/10.1371/journal.pntd.0011205
Anthelmintic drug discovery: target identification, screening methods and the role of open science Partridge, F.A., Forman, R., Bataille, C.J.R., Wynne, G.M., Nick, M., Russell, A.J., Else, K.J. and Sattelle, D.B. 2020. Anthelmintic drug discovery: target identification, screening methods and the role of open science. Beilstein Journal of Organic Chemistry. 16, pp. 1203-1224. https://doi.org/10.3762/bjoc.16.105
2019
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis Faravelli, G., Raimondi, S., Marchese, L., Partridge, F.A., Soria, C., Mangione, P.P., Canetti, D., Perni, M., Aprile, F.A., Zorzoli, I., Di Schiavi, E., Lomas, D.A., Bellotti, V., Sattelle, D.B. and Giorgetti, S. 2019. C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Scientific Reports. 9 19960. https://doi.org/10.1038/s41598-019-56498-5
2018
Improved reference genome of Aedes aegypti informs arbovirus vector control. Matthews, B.J., Dudchenko, O., Kingan, S.B., Koren, S., Antoshechkin, I., Crawford, J.E., Glassford, W.J., Herre, M., Redmond, S.N., Rose, N.H., Weedall, G.D., Wu, Y., Batra, S.S., Vosshall, L.B. and Partridge, F. 2018. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 563, pp. 501-507. https://doi.org/10.1038/s41586-018-0692-z
2018
The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease Furutani, S., Ihara, M., Lees, K., Buckingham, S.D., Partridge, F.A., David, J.A., Patel, R., Warchal, S., Mellor, I.R., Matsuda, K. and Sattelle, D.B. 2018. The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease. International Journal for Parasitology: Drugs and Drug Resistance. 8 (2), pp. 350-360. https://doi.org/10.1016/j.ijpddr.2018.06.001
2018
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Partridge, F.A., Forman, R., Willis, N.J., Bataille, C.J.R., Murphy, E.A., Brown, A.E., Heyer-Chauhan, N., Bruno Marinič, B., Sowood, D.J.C., Wynne, G.M., Else, K.J., Russell, A.J. and Sattelle, D.B. 2018. 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. PLoS Neglected Tropical Diseases. 12 (7) e0006487. https://doi.org/10.1371/journal.pntd.0006487
2018
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes Partridge, F.A., Brown, A.E., Buckingham, S.D., Willis, N.J., Wynne, G.M., Forman, R., Else, K.J., Morrison, A.A., Matthews, J.B., Russell, A.J., Lomas, D.A. and Sattelle, D.B. 2018. An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes. International Journal for Parasitology: Drugs and Drug Resistance. 8 (1), pp. 8-21. https://doi.org/10.1016/j.ijpddr.2017.11.004
2017
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. Partridge, F.A., Murphy, E.A., Willis, N.J., Bataille, C.J., Forman, R., Heyer-Chauhan, N., Marinič, B., Sowood, D.J., Wynne, G.M., Else, K.J., Russell, A.J. and Sattelle, D.B. 2017. Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. PLoS Neglected Tropical Diseases. 11 (2) e0005359. https://doi.org/10.1371/journal.pntd.0005359
Preprint: A drug repurposing screen for whipworms informed by comparative genomics Avril Coghlan, Frederick A. Partridge, María Adelaida Duque-Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T. Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E. Brown, Sirapat Tonitiwong, David B. Sattelle and Matthew Berriman 2023. Preprint: A drug repurposing screen for whipworms informed by comparative genomics. biorxiv.org. https://doi.org/10.1101/2023.03.02.530747
